Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine m

Discussion in 'Scientific Studies' started by paymanz, Aug 9, 2015.

  1. paymanz

    paymanz Member

    Joined:
    Jan 6, 2015
    Messages:
    2,650
    Gender:
    Male
    http://www.ncbi.nlm.nih.gov/pubmed/25201602


    We previously demonstrated that iron overload induces liver damage by causing the formation of reactive oxygen species (ROS). Taurine is a potent free radical scavenger that attenuates the damage caused by excessive oxygen free radicals. Therefore, the aim of the present study was to investigate whether taurine could reduce the hepatotoxicity of iron overload with regard to ROS production. Mice were intraperitoneally injected with iron 5 days/week for 13 weeks to achieve iron overload. It was found that iron overload resulted in liver dysfunction, increased apoptosis and elevated oxidative stress. Taurine supplementation increased liver taurine levels by 40% and led to improved liver function, as well as a reduction in apoptosis, ROS formation and mitochondrial swelling and an attenuation in the loss of the mitochondrial membrane potential. Treatment with taurine mediated a reduction in oxidative stress in iron‑overloaded mice, attenuated liver lipid peroxidation, elevated antioxidant enzyme activities and maintained reduced glutathione levels. These results indicate that taurine reduces iron‑induced hepatic oxidative stress, preserves liver function and inhibits hepatocyte apoptosis. Therefore, taurine may be a potential therapeutic drug to reduce liver damage caused by iron overload.
     
  2. narouz

    narouz Member

    Joined:
    Jul 22, 2012
    Messages:
    4,429
    Very interesting, paymanz.

    I noticed, when I would have heart racing/palps/skipping etc,
    during the period when I was hypothyroid,
    that if I would take about a gram of taurine
    the palps would often gradually abate.

    I know iron--too high or too low in the body--can cause palps.
     
  3. OP
    paymanz

    paymanz Member

    Joined:
    Jan 6, 2015
    Messages:
    2,650
    Gender:
    Male

    interesting
     
Loading...