Taurine/glycine Ratio As A Biomarker Of Stress

[mayweatherking]

does anyone know if taurine supplementation can deplete glycine?

 

[Peatress]

All that gelatine.......

Glycine administration decreases hepatic taurine content in mice - PubMed

The administration of glycine (2 mg/g) to mice showed marked increases in the hepatic content of some amino acids, specially glycine, serine and citrulline, but produced a notorious decrease in the concentration of taurine and aspartic acid. The depletion of taurine was higher than 50% after one...

pubmed.ncbi.nlm.nih.gov

 

[Jamsey]

All that gelatine.......

Glycine administration decreases hepatic taurine content in mice - PubMed

The administration of glycine (2 mg/g) to mice showed marked increases in the hepatic content of some amino acids, specially glycine, serine and citrulline, but produced a notorious decrease in the concentration of taurine and aspartic acid. The depletion of taurine was higher than 50% after one...

pubmed.ncbi.nlm.nih.gov

Considering this is only happening in the liver, it seems likely that this is mostly related to an increase in production of glyco-conjugated bile salts and a decrease in production of taurine-conjugated bile salts based on the availability of glycine. Through a little dive down the rabbit hole of bile acid/salt research, they seem to function very similarly, making bile acids more water soluble and reducing bile acid toxicity among other effects, so I think this is less of a depletion effect and more of a substitution based on availability, or perhaps even a bodily preference for glycoconjugated bile salts.

Possibly relevant research:

Comparison of the arrhythmogenic effects of tauro- and glycoconjugates of cholic acid in an in vitro study of rat cardiomyocytes - PubMed

Obstetric cholestasis is associated with intrauterine death. In obstetric cholestasis, primary bile acids are more commonly conjugated with taurine than glycine, while glycoconjugates predominate in normal pregnancy. Using an in vitro model of rat cardiomyocytes, we compared the effect of tauro-...

pubmed.ncbi.nlm.nih.gov

 

[Peatress]

Considering this is only happening in the liver, it seems likely that this is mostly related to an increase in production of glyco-conjugated bile salts and a decrease in production of taurine-conjugated bile salts based on the availability of glycine. Through a little dive down the rabbit hole of bile acid/salt research, they seem to function very similarly, making bile acids more water soluble and reducing bile acid toxicity among other effects, so I think this is less of a depletion effect and more of a substitution based on availability, or perhaps even a bodily preference for glycoconjugated bile salts.

Possibly relevant research:

Comparison of the arrhythmogenic effects of tauro- and glycoconjugates of cholic acid in an in vitro study of rat cardiomyocytes - PubMed

Obstetric cholestasis is associated with intrauterine death. In obstetric cholestasis, primary bile acids are more commonly conjugated with taurine than glycine, while glycoconjugates predominate in normal pregnancy. Using an in vitro model of rat cardiomyocytes, we compared the effect of tauro-...

pubmed.ncbi.nlm.nih.gov

Thank you. I wonder if it would be prudent to supplement a little taurine if someone is using a lot of gelatin/glycine?

 

[Jamsey]

Thank you. I wonder if it would be prudent to supplement a little taurine if someone is using a lot of gelatin/glycine?

It definitely wouldn’t hurt. But, I also doubt that it’s necessary. As Ray says in,

Gelatin, stress, longevity

Ray Peat

raypeat.com

“Another type of amino acid, taurine, is structurally similar to glycine (and to beta amino propanoic acid, and to GABA)”

So, they are likely very similar in function and likely can substitute for each other in most situations.

 

[Peatress]

It definitely wouldn’t hurt. But, I also doubt that it’s necessary. As Ray says in,

Gelatin, stress, longevity

Ray Peat

raypeat.com

“Another type of amino acid, taurine, is structurally similar to glycine (and to beta amino propanoic acid, and to GABA)”

So, they are likely very similar in function and likely can substitute for each other in most situations.

Thanks for reminding me of that quote.

 

[Beatrix_]

What an interesting thread... A couple of months ago I found out through experimentation that a combo of MgTau and MgGly works far much better for me than either one alone.

 

[Elderflower j58]

I really like this guy... pottengers human, good information with a dash of satire comedy




View: https://youtu.be/oSuXP0r7jIE

 

[Peatress]

I'm going to try mixing in some taurine into my MgGly and see how that works. Thanks @Beatrix_

I've been meaning to read up on Irish history - covid happened and I got distracted. That video is very informative thanks @Elderflower j58
One of my favorite meals is Irish stew made with neck of lamb. Happy days!

 

[Elderflower j58]

I'm going to try mixing in some taurine into my MgGly and see how that works. Thanks @Beatrix_

I've been meaning to read up on Irish history - covid happened and I got distracted. That video is very informative thanks @Elderflower j58
One of my favorite meals is Irish stew made with neck of lamb. Happy days!

Glad you enjoyed it I am Irish myself and I remember my mother's
and grandmothers lamb stew very well, we also had roast stuffed cows heart for a Sunday joint and boiled beef tongue
Oxtail stew every Thursday..... .Aaa
Those halcyon days.

 

[Peatress]

Glad you enjoyed it I am Irish myself and I remember my mother's
and grandmothers lamb stew very well, we also had roast stuffed cows heart for a Sunday joint and boiled beef tongue
Oxtail stew every Thursday..... .Aaa
Those halcyon days.

Cool. Could you recommend a good book on Irish history? I particularly interested in the famine years.

 

[Elderflower j58]

Cool. Could you recommend a good book on Irish history? I particularly interested in the famine years.

Paddy's Lament, Ireland 1846-1847: Prelude to Hatred Paddy's Lament, Ireland 1846-1847: Prelude to Hatred: Amazon.co.uk: Books


I read this book about 15 years ago and thoroughly enjoyed it heartbreaking and inspiring, but very true to history.

 

[Peatress]

Paddy's Lament, Ireland 1846-1847: Prelude to Hatred Paddy's Lament, Ireland 1846-1847: Prelude to Hatred: Amazon.co.uk: Books


I read this book about 15 years ago and thoroughly enjoyed it heartbreaking and inspiring, but very true to history.

Thank you!!

 

[proteome]

a prolactin test won't fly!

I've had several tests done with this lab: Prolactin Blood Testing - Fast Prolactin Testing Near You

 

[Osukhan]

I really like this guy... pottengers human, good information with a dash of satire comedy




View: https://youtu.be/oSuXP0r7jIE

I have been binge watching a lot of his videos, I already do a lot of the things he recommends and have added a few things after watching some of the videos. He is Peaty and Anti-peaty at the same time you know what i mean...

 

[AinmAnseo]

Paddy's Lament, Ireland 1846-1847: Prelude to Hatred Paddy's Lament, Ireland 1846-1847: Prelude to Hatred: Amazon.co.uk: Books


I read this book about 15 years ago and thoroughly enjoyed it heartbreaking and inspiring, but very true to history.

Excellent recommendations.
And if you want to see a documentary that will tell the story of the potato blights in video, see "When Ireland Starved". Hard to watch, but there it is.