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Taurine Enhances Bioavailability Of Vitamins K, A, D, E

Discussion in 'Scientific Studies' started by haidut, Jul 21, 2015.

  1. haidut

    haidut Member

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    The fat soluble vitamins are a great tool to help metabolism and improve overall health. However their oral usage is sometimes hindered by their requirements for ingestion of fat. In the case of vitamin K2 (MK-4) the fat requirement can be large (35g+) and thus inconvenient to implement while on the go or when restricting fat intake for various purposes.
    This study claims that taurine improves the oral bioavailability of all fat-soluble vitamins and especially vitamins A and K.

    http://www.ncbi.nlm.nih.gov/pubmed/11128549

    "...In the literature taurine is characterized as a non-specific growth or blood clotting factor, an antioxidant, a membrane protector, or a regulator of calcium ion homeostasis, just as vitamins A, D, E, F, and K are similarly characterized. On the basis of recent finding concerning the relationship between taurine and the aldehyde of vitamin A-retinal (Petrosian and Haroutounian, 1988, 1998; Petrosian et al., 1996), as well as on the basis of data from the literature, we now suggest a hypothesis that taurine promotes the bioavailability of the lipid soluble vitamins A, D, E, K, and F, probably by forming different types of water soluble, easily hydrolyzable complexes. It is quite possible that the ability of taurine to convert lipids and lipid soluble substances into a water soluble state is the key to understanding the unusually wide diversity of biological phenomena associated with taurine."

    If somebody can get the article and PM it to me I can post more detailed info such as suggested dosages, etc.
     
  2. Such_Saturation

    Such_Saturation Member

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    Perhaps it can allow the excretion of fats.
     
  3. paymanz

    paymanz Member

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    it also can increase taurine glycine ratio in bile , which is good sometimes as in some disorders this ratio is so low.it also makes good quality bile which itself has stimulating effect on cell metabolism.
     
  4. LucH

    LucH Member

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    Taurine facilitates manufacture of bile salts (taurocholates) that emulsify meal fat, which allows a better action of pancreatic lipase on the fat, so a better digestion.

    Taurine is also used to bring the magnesium in the cells and in neurons among others ... It serves as Mg carrier. B6 facilitates retention.
    LucH
     
  5. NathanK

    NathanK Member

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    Nice, if someone were to feel strong effects from supplementing taurine, do you think that says something about the person's digestion or assimilation of nutrients? It's intrigued me that I've seen some feel great after supplementing and others hardly noticing anything.
     
  6. Such_Saturation

    Such_Saturation Member

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    No I'm saying it could allow you to excrete fat in the urine. Taurine in the kidney is tightly regulated.
     
  7. OP
    haidut

    haidut Member

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    So, in theory that would help the excretion of PUFA and/or steroids like estrogen? We already know that taurine keeps PUFA oxidation under control, if it could also help excrete it by making it more water soluble that would be great.
     
  8. Such_Saturation

    Such_Saturation Member

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    But how can that be measured?
     
  9. OP
    haidut

    haidut Member

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    http://raypeat.com/articles/articles/ti ... ogen.shtml
    "...Estrogen is inactivated, mainly in the liver and brain, by being made water soluble by the attachment of glucuronic acid and/or sulfuric acid."

    Taurine is the main source for the production of sulphuric acid, so this supports the theory of taurine helping with estrogen removal. I guess if the main products are glucuronidated and sulfated etsrogens, one could just take a urine estrogen test (which measures both kinds) and compare the levels before and after taurine administration. I would combine this with a blood test for estrogens just to make sure that the increased urine excretion of estrogens is not due to taurine somehow increasing plasma estrogens. Any doctor can order both tests and I think some of the independent vendors like DirectLabs offer urine estrogen tests as well.
     
  10. Such_Saturation

    Such_Saturation Member

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    I personally notice thick and foamy urine after taking taurine. Maybe it's that.
     
  11. Makrosky

    Makrosky Member

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    So if one adopts a diet with very few PUFA and more Sat fat, can it also make the urine foamy since you will be slowly removing PUFA from your body ? Does this make sense ?
     
  12. aguilaroja

    aguilaroja Member

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    While taurine may have specific effects, high ("excess") protein/amino acid intake can cause high amino acids in the urine, resulting in foamy urine.
     
  13. OP
    haidut

    haidut Member

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    Yes, proteinuria is usually what's causing the foamy urine. However, as Ray mentioned, having high levels of stress hormones can also make the urine foamy. You can notice it during/after drinking alcohol as it depletes liver glycogen (which will result in higher adrenalin and cortisol) while at the same time inhibiting gluconeogenesis. One way to prevent this from happening is by taking niacinamide.
     
  14. Such_Saturation

    Such_Saturation Member

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    Well I also get it from a teaspoon of glycine. Perhaps I am flushing money :ss
     
  15. milk_lover

    milk_lover Member

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  16. mirc12354

    mirc12354 Member

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    How much taurine should one take with K2 (MK-4) to get the same level of its bioavailability as 35g of fat?

    Could taking K2 with taurine help with (prevent some of) the side-effects at high oral daily doses of 15mg+ (insomnia, etc.)? I was also wondering if taking the transdermal route (Kuinone) with high doses K2 could also prevent some of the side effects of high oral doses?
     
  17. OP
    haidut

    haidut Member

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    Human studies with cystic fibrosis leading to deficiency of fat absorption showed that even 2g taurine restored normal fat absorption after 1 month. There is no data that I know of showing how much taurine you need to get the equivalent of X grams of fat for absorbing vitamin K. But taking the 1g-2g taurine daily should at least ensure that wharever fat you eat you absorb it and the fat soluble vitamins that depend on it.
     
  18. dfspcc20

    dfspcc20 Member

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    Taurine is degraded by heat, correct? Do you think it's possible to get enough from food alone, considering most of the food we eat is cooked or pasteurized?
     
  19. OP
    haidut

    haidut Member

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    Scallops and cod have high content of taurine so that would one good food source. All amino acids are sensitive to heat, including the bad ones like tryptophan and cysteine. So the processed food has an unintended good side effects of being low on some of the bad amino acids due to processing. On the flip side, we don't know what those aminos got broken down into. Could be something even more toxic...
     
  20. mirc12354

    mirc12354 Member

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    So taking niacinamide before drinking would be wise? What about thiamine (as you have written in the past) plus niacinamide before drinking?
     
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