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Taurine Effective Against Hypervitaminosis A In Rats

Discussion in 'Scientific Studies' started by goodandevil, Feb 13, 2016.

  1. goodandevil

    goodandevil Member

    Joined:
    May 27, 2015
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    Abstract
    A study was undertaken to investigate the effect of taurine on the toxicity of vitamin A in male wistar rats. The rats were divided into six groups and fed different diets with or without supplements of 5% taurine and 25,000–50,000 (IU) vitamin A for 2 months. It was found that the body weight of rats, the ratios of liver and kidney weight to body weight, and the level of glutathione in the liver were decreased with increasing the dose of vitamin A. The levels of vitamin A in the liver and kidney, the levels of thiobarbituric acid-reactive substances (TBARS) in the plasma and liver, the activities of aspartate transaminase (AST) and alanine transaminase (ALT) in the plasma, and the levels of blood urea nitrogen (BUN) and creatinine in the plasma of rats were increased with the increasing dose of vitamin A. Hence, symptoms of vitamin A toxicity in rats included loss of body weight, hepatotoxicity and nephrotoxicity. However, these toxic effects of vitamin A were significantly reduced when the rats were fed the diet with the supplement of taurine. Furthermore, the level of vitamin A in the serum of rats treated with taurine and vitamin A was higher than that of rats treated with vitamin A alone. This indicated that taurine might play a role in reducing the toxic effect of vitamin A in rats.
     
  2. schultz

    schultz Member

    Joined:
    Jul 29, 2014
    Messages:
    1,776
    Wow, that is a tremendous dose for a rat.

    Interestingly, the 50,000IU+Taurine group had less vitamin A in the liver than the 25,000IU group that didn't get any taurine, but had higher serum and kidney levels. Unfortunately they only hint at what they think the taurine is doing...

    "Taurine is a special amino acid, which possesses an amino group and a sulfonate group. These functional groups might bind with vitamin A, and then stimulate the excretion of such compounds."

    Ray has talked about the liver attaching sulfate to various things, so I wonder if taurine increases the livers ability to do this, or simply provides the sulfate? It might be interesting if this were true as it's possible it helps in getting rid of other things like estrogen.

    In the study they mention that mollusks are a good source of taurine, which I didn't know. I wonder if that changes with cooking?
     
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