"The researchers purified and identified a compound from this extract that acted against B. burgdorferi. It turned out to be hygromycin A [aka totomycin], an antibiotic discovered in 1953. Previous research on hygromycin A was abandoned due to its weak activity against most bacteria.
The team confirmed that hygromycin A did not kill most bacteria, including many beneficial gut microbes. But it did kill B. burgdorferi and other bacteria in the same class very effectively.
...
Hygromycin A had no toxic effects on cultured human cells. In a mouse model of Lyme disease, 5 days of hygromycin A treatment cleared the infection as well as broad-spectrum antibiotics did. But unlike the broad-spectrum antibiotics, hygromycin A didn't disrupt the gut microbiome."
A targeted antibiotic for treating Lyme disease
@haidut thought you might be interested in this or know something about it
The team confirmed that hygromycin A did not kill most bacteria, including many beneficial gut microbes. But it did kill B. burgdorferi and other bacteria in the same class very effectively.
...
Hygromycin A had no toxic effects on cultured human cells. In a mouse model of Lyme disease, 5 days of hygromycin A treatment cleared the infection as well as broad-spectrum antibiotics did. But unlike the broad-spectrum antibiotics, hygromycin A didn't disrupt the gut microbiome."
A targeted antibiotic for treating Lyme disease
@haidut thought you might be interested in this or know something about it
