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If your liver isn't working very well (fatty liver would count) then it would have trouble converting T4 into the active T3 so a combination of both would be helpful. Thiamine is also very helpful to improve liver function.
pubmed.ncbi.nlm.nih.gov
journals.biologists.com
www.forefronthealth.com
Why mixed t4/t3 if the liver cannot convert it? Why not just avoid t4 completely?If your liver isn't working very well (fatty liver would count) then it would have trouble converting T4 into the active T3 so a combination of both would be helpful. Thiamine is also very helpful to improve liver function.
High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition - PubMed
Fatty liver is an abnormal metabolic condition of excess intrahepatic fat. This condition, referred to as hepatic steatosis, is tightly associated with chronic liver disease and systemic metabolic morbidity. The most prevalent form in humans, i.e. non-alcoholic fatty liver, generally develops...High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition
Editor's choice: Experiments using overnourished sheep raised on a high-calorie liver-fattening diet, treated with and without thiamine, revealed that vitamin B1 protects against the development of fatty liver driven by overnutrition.
Thiamine also improves thyroid function.
Thiamine and Thyroid: 3 Hidden Thyroid Benefits You Don’t Want to Miss
Learn the how thiamine can help restore your metabolism and protect your thyroid with these 3 hidden thiamine and thyroid benefits.
The liver needs energy in order to convert T4 into T3. Supplemented T3 provides that energy; it "primes the pump". Thiamine is also required by the liver's mitochondria to convert glucose into ATP (energy).
Wouldn’t that mean that you may need t3 dose to be higher than t4? Like 2:1 in favour of t3. Because sometimes the t4 is just too much.
I don't think so.
Why is taking t4 so important? The liver doesn’t convert it properly, and it may convert to rt3. Ray peats articles never say anything about having more t3 than t4. It seems to me that Ray doesn’t account for someone with a bad liver.I don't think so.
suggested reading:
Hypothyroidism : the unsuspected illness : Barnes, Broda O. (Broda Otto), 1906- : Free Download, Borrow, and Streaming : Internet Archive
Includes bibliographical references (p. 287-297)archive.org
also this audio show: https://www.toxinless.com/polsci-080911-thyroid-and-regeneration.mp3 (terrible sound quality, well worth the effort).
Ray discussed people with poor liver function that is commonly caused by high estrogen. The liver has to detox the estrogen out of the body; high estrogen overburdens the liver and results in poor t4 to t3 conversion. This problem is why synthetic T4 thyroid products do not work for anyone except young healthy males (who have low estrogen and healthy livers).
So I'm not against taking t4. I can still take t4 but not at very high dosages. According to Broda Barnes, you should continue to increase the t3 dose until your symptoms disappear. If my symptoms don't disappear until a higher t3 dose and too much t4 makes me colder, then you can safely say that the ratio of t3 to t4 will be larger or 1:1.
Here's a ringer for the equation: thiamine is needed for thyroid function. Too much thyroid supplementation = hyperthyroidism which blocks thiamine function.
Wouldn’t more t3 make you warmer? What were your temps and pulses like? It’s probably due to the ratios of your thyroid med.
Nope. Even though I was taking 180 mg of prescription desiccated thyroid (my optimum dose for the previous 5 years), my temp was a full degree below normal (97.6 @ 3:00pm) and my pulse was all over the place (high, low, erratic). These symptoms were caused by my thiamine function being blocked by Bactrim antibiotic. My thiamine function was still blocked/nonfunctioning a full 4 months after stopping the Bactrim antibiotic. I discovered the answer to the problem by taking around 300mg of thiamine hcl with some water. Within 45 minutes, my temperature increased by a full degree and all my inflammation/pain disappeared. The pain was caused by lactic acidosis; the thiamine resolved that issue quickly (less than an hour).
Too much t3 = hyperthyroidism. Hyperthyroidism depletes thiamine (makes a deficiency/functional blockage worse). Thiamine function is required for oxidative metabolism. Good thyroid function is also required for oxidative metabolism. If your oxidative metabolism isn't working you cannot make ATP so you can't maintain normal body temperature or do much of anything else.
What kind of pain did you have prior to the thiamine supplementation? Also, I've seen you post about thiamine several times, but do you have like a full testimonial/experience log or something regarding your own experience with it? Along with symptoms prior, how long you've taken it etc. Thanks
You can look at my prior posts; I've posted a lot about my experience with thiamine. My pain was severe. I could not roll over in bed with out a LOT of pain. Walking to the bathroom was excruciating. Lactic acidosis is very very painful. I tried taking aspirin, a gram at a time; it didn't help at all. Thiamine resolved it quickly.
Okay thank you for the response, I will read up on your posts as well. I realized now this thread isn't about thiamine. Sorry for "derailing".
