Syndrome X

[Peatness]

Dr Robin Roberts explains Syndrome X and how it can be treated​

View: https://www.youtube.com/watch?v=es2OSeBrJ7s&t=191s

Microvascular Angina (Cardiac Syndrome X) | Doctor

Microvascular Angina (previously known as Cardiac syndrome X (CSX)) is characterised by angina-like chest discomfort. Written by a GP.

patient.info

 

[Peatness]

Ray Peat Email Advice Depository

Q: any other thoughts on altitude tents, would sleeping with your head under a pillow and blanket provide some benefits similar to bag breathing and high altitudes? its odd it smelled bad, maybe some odd materials or something. are you sure the supplement was just creatine, many of these...

raypeatforum.com

Assessing microvascular changes in systemic sclerosis diagnosis and management - PubMed

Microvascular damage and dysfunction represent the earliest morphological and functional markers of systemic sclerosis (SSc), a progressive connective tissue disease characterized by vascular abnormalities and diffuse fibrosis in the skin and internal organs. These early microvascular changes...

pubmed.ncbi.nlm.nih.gov

 

[Peatness]

B-vitamin deficiency in hospitalized patients with heart failure - PubMed

The impact of heart failure and its treatment on specific nutrient requirements is unknown. Furthermore, depletion of water-soluble B vitamins that play key roles in the production of cellular energy in patients with heart failure can contribute to depletion of energy reserves observed in the...

pubmed.ncbi.nlm.nih.gov

 

[Kayaker]

B-vitamin deficiency in hospitalized patients with heart failure - PubMed

The impact of heart failure and its treatment on specific nutrient requirements is unknown. Furthermore, depletion of water-soluble B vitamins that play key roles in the production of cellular energy in patients with heart failure can contribute to depletion of energy reserves observed in the...

pubmed.ncbi.nlm.nih.gov

"Use of common B-vitamin-containing supplements by patients with heart failure did not significantly reduce deficiency rates in comparison with those who did not use supplements"

Then I thought they are excreted more.

"Finally, while 80% of patients with heart failure took diuretics, neither the dose nor the duration of furosemide use was related to the presence of either B-2 or B-6 deficiency"

But what about B1 deficiency?

I guess their bodies use the vitamins up faster. In which case, taking them is obviously a good idea, but there's likely an underlying problem.

 

[Peatress]

Thiamine (Vitamin B1) Deficiency Symptoms, Causes & Treatment - SelfHacked

Thiamine deficiency can cause severe nerve and heart damage. Click to learn the signs, symptoms and ways to prevent it.

selfhacked.com

Patients with heart failure are especially vulnerable, as they receive large doses of furosemide (Lasix) and other potent diuretics [42, 43].

In one clinical trial, high doses of furosemide (80 mg/day) caused severe thiamine deficiency in 98% of patients (24/25). Besides increasing urination, this drug may also directly inhibit thiamine uptake into the cells that need it [44, 45].

 

[Bioenergy_Space]

"Use of common B-vitamin-containing supplements by patients with heart failure did not significantly reduce deficiency rates in comparison with those who did not use supplements"

Then I thought they are excreted more.

"Finally, while 80% of patients with heart failure took diuretics, neither the dose nor the duration of furosemide use was related to the presence of either B-2 or B-6 deficiency"

But what about B1 deficiency?

I guess their bodies use the vitamins up faster. In which case, taking them is obviously a good idea, but there's likely an underlying problem.

Also reduced cellular uptake. There is little evidence because it has not been studied, but I believe that stressed cells do not uptake vitamins from the blood at the same rate as highly energized cells. It seems to be a measure to spare the vitamins for more essential tissues. For example Ray talked about a study where after inducing B2 deficiency, higher dosages were required to avoid subsequent deficiency symptoms, even when the deficiency should have been corrected. Abram Hoffer hypothesised that certain illnesses would cause "vitamin dependencies" where dosages far larger than what would be reasonably expected were needed to make an improvement.

 

[Peatress]

I remember reading about Hoffer's theory of vitamin dependencies. I wonder if this applies to all the B vitamins? @Bioenergy_Space

 

[Bioenergy_Space]

I remember reading about Hoffer's theory of vitamin dependencies. I wonder if this applies to all the B vitamins? @Bioenergy_Space

Yes, and probably to all micronutrients that have dedicated transport proteins. But it also means that we have many ways of healing disease.

 

[Peatress]

Yes, and probably to all micronutrients that have dedicated transport proteins. But it also means that we have many ways of healing disease.

Intresting, thanks