Suramin And Autism

[_lppaiva]

Suramin and Autism - UC San Diego Health

"Suramin is a 100-year-old drug developed to treat African sleeping sickness and river blindness. Though it has been investigated for other diseases, including cancer, it is not approved for any therapeutic use in the United States.
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However, a small, randomized clinical trial conducted by Robert K. Naviaux, MD, PhD, professor of medicine, pediatrics and pathology, and colleagues at University of California San Diego School of Medicine have found that a single intravenous dose of suramin produced dramatic, but transient, improvement of core symptoms of Autism Spectrum Disorder (ASD). Currently, there are no drugs approved for treating the core symptoms of ASD.

More broadly, the trial findings support the “cell danger response theory,” which posits that autism and other chronic conditions are fundamentally driven by metabolic dysfunction—and thus treatable. Naviaux and his co-authors propose larger, longer clinical trials to assess suramin (or similar drugs) as an ASD treatment."

Suramin (Injection route) - PubMed Health - National Library of Medicine - PubMed Health
Given that, there is a big list of side effects, like nausea, vomiting, fever, headache, skin tingling, diarrhea, etc
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[methylenewhite]

"Once inside parasites, suramin combines with proteins, especially trypanosomal glycolytic enzymes to inhibit energy metabolism" says wiki.

"The energy metabolism of Trypanosomatidae varies considerably, not only between species but also between distinct life cycle stages of the same species (7, 17). Several Trypanosomatidae rely on glycolysis of carbohydrates for their ATP production, whereas the energy metabolism of other Trypanosomatidae comprises substantial mitochondrial metabolism in which amino acids are often used as substrates for ATP production. Bloodstream form Trypanosoma brucei, which lives in a glucose-rich environment, is entirely dependent on degradation of glucose into pyruvate by glycolysis, whereas procyclic T. brucei living in the gut of tsetse flies degrades carbohydrates and amino acids by a more-complex metabolism involving substantial mitochondrial metabolism (2, 5, 15). Next to carbohydrate abundance, the type of available nutrients seems to correlate with the differences in energy metabolism in trypanosomatids as well. Insect stages of African trypanosomes and of Trypanosoma cruzi and Leishmania spp. that inhabit arthropod intestines, as well as trypanosomatids that live in intracellular compartments of the endocytotic pathway of mammalian cells, such as amastigote stages of T. cruzi and Leishmania spp., use the abundantly available amino acids in their environment as substrates for energy metabolism involving mitochondrial pathways (4, 7, 17). Therefore, multiple observations argue for the suggestion that nutrient supply in the natural environment correlates with the energy metabolism present in the distinct trypanosomatid species and life cycle stages."

Energy Metabolism of Bloodstream Form Trypanosoma theileri

So it's a glycolysis inhibitor, right? It kills parasites because they don't have alternative energy source.

 

[Inaut]

View: https://m.youtube.com/watch?v=a1fpwHlusyg

 

[S-VV]

Since Naviaux will release Suramin in about the year 2176, it is nice to know that pyridoxal 5 phosphate is a purinergic antagonist with varying affinities for the subtypes

Pyridoxal 5'-phosphate is an ATP-receptor antagonist in freshly isolated rat cardiomyocytes - PubMed

Although extracellular ATP is considered to exert a positive inotropic action on the myocardium through purinoceptors, very little information is available regarding interventions which may modify the actions of ATP on the heart. We report here that pyridoxal 5'-phosphate (PLP), an active form...

pubmed.ncbi.nlm.nih.gov

 

[S-VV]

Also, suramin is a TGF antagonist, in case this whole eATP CDR thing doesnt pan out in the end

Suramin inhibits growth and transforming growth factor-beta 1 (TGF-beta 1) binding in osteosarcoma cell lines - PubMed

Autocrine production of growth factors has been shown to be involved in the multistep process of tumorigenesis. The ability of suramin, a polyanionic anti-parasitic drug, to block growth factor-induced cell proliferation makes it a potential antineoplastic drug. We studied the effects of suramin...

pubmed.ncbi.nlm.nih.gov

 

[Braveheart]

View: https://www.bitchute.com/video/9JPCaD4awC4t/

Suramin shows promise as COVID-19 treatment

A new study published on the preprint server bioRxiv reports the elucidation of the mechanism of inhibition of SARS-CoV-2 by a non-nucleotide inhibitor called suramin. This is the first such compound to be shown to have such activity and shows promise for use as a repurposed drug against COVID-19.

www.news-medical.net

Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin - Nature Structural & Molecular Biology

The antiparasitic drug suramin directly inhibits SARS-CoV-2 RNA-dependent RNA polymerase by blocking binding of the RNA template–primer duplex and entry of nucleotide triphosphate to the catalytic site.

www.nature.com

my apologies if this has already been posted

 

[Inaut]

Suramin: The discovery of an old anticancer drug - Medical Oncology

Suramin, an antitrypanosomal agent used since the early 1920s for the treatment of onchocerciasis and African sleeping sickness is now under active investigation as an antineoplastic drug characterized by an unusual and interesting mechanism of action and by a peculiar pattern of toxicity. Its...

link.springer.com