Suppressed Immunity, Not Viruses (HPV), May Be The Cause Of (skin) Cancer

haidut

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Recently, I posted some threads in regards to immunosuppression and cancer. Here are two that provide a good overview and tie together the immunosuppressive effects of PUFA, estrogen, and cortisol with the protective effects of vitamin A, E, D, progesterone, etc.

PUFA Are Immunosuppressive, Fasting And Protein Restriction (possibly) Even More So
Vitamin D May Stop Melanoma Growth

However, despite the accumulating evidence that it is suppressed immune system allowing the cancer to form and spread, mainstream medicine keeps chasing "evil" entities that can be "killed" or vaccinated against. One of the most notable examples is the viral theory of cancer.

Oncovirus - Wikipedia

It gave rise to one of the famous anti-cancer vaccines - against human papillomavirus (HPV). That virus is reputed to be the direct cause of cervical, anal, penile, oral, throat an other cancers and the vaccine is heavily marketed to both young children (of either sex) as well as adults. Yet, few people know that a true causal link between HPV and any of those cancers was never really established. Not only that, but it has been linked to a so-called "HANS" (syndrome) condition that strikes the central nervous system and so far the only treatment for it seems to be administration of adenosine receptor antagonists such as theophylline and caffeine.

https://www.autonomicneuroscience.com/article/S1566-0702(16)30195-3/abstract

Now, the study below discovered that HPV may also be involved in one of the well-known skin cancers - squamous cell carcinoma (SCC). Yet, the study also found that it is not the virus per se that caused SCC. It was the suppressed immune system that allowed both the cancer and HPV to take hold. As such, HPV appears to be little more than a symptom of a suppressed immune system - i.e. another instance of the "innocent bystander" effect, of which the most famous example is cholesterol (and its "role" in CVD). Could the same be true of other viral "diseases" too?? In other words, could those viruses simply be symptoms and not causes of many terrible conditions for which officially the is no cure? Well, I'll let the reader judge for herself/himself and will only mention that the "flu", "AIDS", Ebola, etc have already been linked to suppressed immune system and endotoxin overload, with the virus playing at most a minor and often completely peripheral role in the pathology.

While the study below only discusses the (non-existent) role of HPV in SCC, I see no reason why the same findings do not also apply to the primary cancers for which HPV has been blamed - i.e. cervical, anal, penile, oral and throat cancers. Little by little, the accumulating evidence exposes the viral theory of cancer as yet another diversion on the path of "heroic medicine" (Heroic medicine - Wikipedia) that currently rules the Western world. Btw, viruses are currently blamed not only for cancer(s) but also for causing a number of autoimmune conditions such as multiple sclerosis (MS), neurodegenerative conditions such as Alzheimer Disease (AD), CVD, diabetes, liver disease, infertility, etc. The very fact that an immune dysfunction has already been established as a cause in all of these conditions strongly suggests that their viral link is, again, either a fraud (to sell vaccines), a diversion (to avoid admitting incompetence) or just shear idiotism on behalf of the people/industries in charge of our health. As I typically say in other posts covering such travesty - "so much for the glory of Rome..."

Immunity to commensal papillomaviruses protects against skin cancer
https://www.medicalnewstoday.com/articles/326967.php

"...The researchers found that the body's immune response to beta-HPV is key. In their experiments, mice that demonstrated an immune response to HPV seemed to have protection from the development of SCC following carcinogenic UV or chemical exposure. Similarly, when the researchers transplanted T cells from those mice into immunocompromised mice, the recipients also developed protection against skin cancer. In short, it is not beta-HPV that encourages SCC in immunocompromised individuals. Instead, it is the loss of immune function that increases the risk of SCC."
 

Don

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Sep 12, 2020
Messages
368
Recently, I posted some threads in regards to immunosuppression and cancer. Here are two that provide a good overview and tie together the immunosuppressive effects of PUFA, estrogen, and cortisol with the protective effects of vitamin A, E, D, progesterone, etc.

PUFA Are Immunosuppressive, Fasting And Protein Restriction (possibly) Even More So
Vitamin D May Stop Melanoma Growth

However, despite the accumulating evidence that it is suppressed immune system allowing the cancer to form and spread, mainstream medicine keeps chasing "evil" entities that can be "killed" or vaccinated against. One of the most notable examples is the viral theory of cancer.

Oncovirus - Wikipedia

It gave rise to one of the famous anti-cancer vaccines - against human papillomavirus (HPV). That virus is reputed to be the direct cause of cervical, anal, penile, oral, throat an other cancers and the vaccine is heavily marketed to both young children (of either sex) as well as adults. Yet, few people know that a true causal link between HPV and any of those cancers was never really established. Not only that, but it has been linked to a so-called "HANS" (syndrome) condition that strikes the central nervous system and so far the only treatment for it seems to be administration of adenosine receptor antagonists such as theophylline and caffeine.

https://www.autonomicneuroscience.com/article/S1566-0702(16)30195-3/abstract

Now, the study below discovered that HPV may also be involved in one of the well-known skin cancers - squamous cell carcinoma (SCC). Yet, the study also found that it is not the virus per se that caused SCC. It was the suppressed immune system that allowed both the cancer and HPV to take hold. As such, HPV appears to be little more than a symptom of a suppressed immune system - i.e. another instance of the "innocent bystander" effect, of which the most famous example is cholesterol (and its "role" in CVD). Could the same be true of other viral "diseases" too?? In other words, could those viruses simply be symptoms and not causes of many terrible conditions for which officially the is no cure? Well, I'll let the reader judge for herself/himself and will only mention that the "flu", "AIDS", Ebola, etc have already been linked to suppressed immune system and endotoxin overload, with the virus playing at most a minor and often completely peripheral role in the pathology.

While the study below only discusses the (non-existent) role of HPV in SCC, I see no reason why the same findings do not also apply to the primary cancers for which HPV has been blamed - i.e. cervical, anal, penile, oral and throat cancers. Little by little, the accumulating evidence exposes the viral theory of cancer as yet another diversion on the path of "heroic medicine" (Heroic medicine - Wikipedia) that currently rules the Western world. Btw, viruses are currently blamed not only for cancer(s) but also for causing a number of autoimmune conditions such as multiple sclerosis (MS), neurodegenerative conditions such as Alzheimer Disease (AD), CVD, diabetes, liver disease, infertility, etc. The very fact that an immune dysfunction has already been established as a cause in all of these conditions strongly suggests that their viral link is, again, either a fraud (to sell vaccines), a diversion (to avoid admitting incompetence) or just shear idiotism on behalf of the people/industries in charge of our health. As I typically say in other posts covering such travesty - "so much for the glory of Rome..."

Immunity to commensal papillomaviruses protects against skin cancer
How a virus might protect against skin cancer

"...The researchers found that the body's immune response to beta-HPV is key. In their experiments, mice that demonstrated an immune response to HPV seemed to have protection from the development of SCC following carcinogenic UV or chemical exposure. Similarly, when the researchers transplanted T cells from those mice into immunocompromised mice, the recipients also developed protection against skin cancer. In short, it is not beta-HPV that encourages SCC in immunocompromised individuals. Instead, it is the loss of immune function that increases the risk of SCC."
Years late reading this but wow exactly what I was looking for. Thanks so much.
 

aliml

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692
1697425006703.png
Effects of Th1/Th2 on tumor progression. Naive T cells become Th1 cells or Th2 cells, following the stimulation by different factors. In Th1 immunity, cells produce pro-inflammatory cytokines, such as interleukin-2 (IL2), interferon-gamma (IFN-γ), and tumor necrosis factor-beta (TNF-β). In Th2 immunity, cells produce antiinflammatory cytokines, such as IL-4, IL-5, IL-6, IL-10, and IL-13. In normal circumstances, Th1 immunity and Th2 immunity approach a balance. But, the presence of tumor cells disrupts this balance. This occuring increased Th2 immunity and decreased Th1 immunity, because of down-regulation of adaptive immunity. This eventually leads to tumor progression. However, if Th1 immunity becomes predominant, this stimulation of immunity can lead to tumor regression.
1697425230614.png
The balancing square model. The 4 T-cell types (Th1, Th2, Th17, and Treg) antagonize each other. The Th1-promoting cytokine, IL-12, is inhibitory to Th2-cell development, whereas the Th2-promoting cytokine, IL-4, blocks Th1-cell development. The Th1-derived IFN-γ blocks Th17-cell development. The Treg inhibits the development of both Th1 and Th2 cells by direct contact.

Th1 and Th2 cells are types of T helper cells that play a role in the immune response to human papillomavirus (HPV) infection and the development of uterine cervical cancer:
  • Research has shown that an imbalance of Th1/Th2 cells is associated with the development and progression of uterine cervical cancer R,R,R. In HPV-infected patients, cytokines secreted by both Th1 and Th2 cells are upregulated, followed by a decrease in Th1 cells and an increase in Th2 cells, leading to an imbalance R,R.
  • In addition to Th1/Th2 imbalance, an imbalance of Th17/Treg cells has also been observed in cervical cancer patients R,R. Treg cells play a role in suppressing the immune response, and their increased presence in HPV-derived lesions suggests a pivotal role in counteracting the host immune response R.
Overall, the Th1/Th2 balance is important in the immune response to HPV infection and the development of cancer.

Several studies have investigated the association between Th1/Th2 balance and SCC:
  • A study on patients with head and neck SCC found that those with advanced disease had a potentially diminished Th1 immune response and a stronger potential Th2 immune response compared to patients with less advanced disease R,R.
  • Another study on patients with esophageal SCC found that Th1 cells were suppressed, while the function of Th2 cells was enhanced R.
  • In uterine cervical cancer patients, an imbalance of Th1/Th2 cells was detected, with decreased levels of circulating Th1 cells and elevated levels of Th2 cells in stage II patients compared to stage I patients R.
These findings suggest that the Th1/Th2 balance can play a role in the immune response to SCC.
 
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