Sugar And Serotonin

kineticz

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Hi hope everyone is doing ok.

I came across this on another specialist site that had some very useful info for my neurotransmitters in relation to high progesterone for example;

'Refined sugar favors conversion of tryptophan to serotonin causing a relative dopamine deficiency and acetylcholine deficiency, which causes disturbances in movement and memory'
 
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kineticz

kineticz

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HDD said:
Do you have a source?

http://www.drkaslow.com/html/premenstru ... romes.html

My estrogen is non-existent on blood tests and it's lists on progesterone excess and estrogen deficiency tell me that my depersonalised mood which still remains at some moments is due to norephiprene reduction. I think some estrogen is good for mood and focus.

Large doses of vitamin E are working spectacularly for my clarity and sex drive. This study says it boosts estrogen and lowers LDL cholesterol. High LDL cholesterol inhibits adrenal steroids. I also do not do well when consuming eggs. I get panic attacks.
 

HDD

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Eggs can cause hypoglycemia which symptoms are similar to panic attack.

Insulin release is also stimulated by amino acids such as leucine, and insulin stimulates cells to absorb amino acids and to synthesize proteins. Since insulin lowers blood sugar as it disposes of amino acids, eating a large amount of protein without carbohydrate can cause a sharp decrease in blood sugar. This leads to the release of adrenalin and cortisol, which raise the blood sugar. Adrenalin causes fatty acids to be drawn into the blood from fat stores, especially if the liver's glycogen stores are depleted, and cortisol causes tissue protein to be broken down into amino acids, some of which are used in place of carbohydrate. Unsaturated fatty acids, adrenaline, and cortisol cause insulin resistance.
A high quality protein such as egg, can cause a stress reaction, and fail to be fully used as protein, if it is eaten without carbohydrates.
http://raypeat.com/articles/articles/Glycemia%
 

HDD

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Estrogen is stored in our tissue. You want low estrogen. Vitamin e is good but you might want to try Progest-e too.
 

Peata

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kineticz said:
HDD said:
Do you have a source?

http://www.drkaslow.com/html/premenstru ... romes.html

My estrogen is non-existent on blood tests and it's lists on progesterone excess and estrogen deficiency tell me that my depersonalised mood which still remains at some moments is due to norephiprene reduction. I think some estrogen is good for mood and focus.

Large doses of vitamin E are working spectacularly for my clarity and sex drive. This study says it boosts estrogen and lowers LDL cholesterol. High LDL cholesterol inhibits adrenal steroids. I also do not do well when consuming eggs. I get panic attacks.

Vitamin E is an estrogen antagonist.

http://raypeat.com/articles/articles/vitamin-e.shtml
 

BobbyDukes

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Higher protein intake would slow the conversion to serotonin, but it's all probably a balancing process. Sugar still feeds the metabolism better than fat.
 

HDD

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"There’s a special problem with the basis for diagnosing estrogen deficiency, because in the absence of anti-estrogen substances such as progesterone, the estrogen in the blood can go to a very low level, because the estrogen is staying inside cells, and progesterone knocks it out of cells, inactivates it, but causes it to appear in the blood stream on its way out the kidneys. So, in the absence of progesterone, doctors will measure a low level of serum estrogen, and prescribe it, even though, under that situation, it’s very likely that their tissues, breast and uterus in particular, are actually overloaded with a chronic supply of estrogen."
 
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kineticz

kineticz

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Peata said:
kineticz said:
HDD said:
Do you have a source?

http://www.drkaslow.com/html/premenstru ... romes.html

My estrogen is non-existent on blood tests and it's lists on progesterone excess and estrogen deficiency tell me that my depersonalised mood which still remains at some moments is due to norephiprene reduction. I think some estrogen is good for mood and focus.

Large doses of vitamin E are working spectacularly for my clarity and sex drive. This study says it boosts estrogen and lowers LDL cholesterol. High LDL cholesterol inhibits adrenal steroids. I also do not do well when consuming eggs. I get panic attacks.

Vitamin E is an estrogen antagonist.

http://raypeat.com/articles/articles/vitamin-e.shtml

According to the link, low doses antagonise estrogen, but high doses can increase it.
 
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kineticz

kineticz

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HDD said:
Eggs can cause hypoglycemia which symptoms are similar to panic attack.

Insulin release is also stimulated by amino acids such as leucine, and insulin stimulates cells to absorb amino acids and to synthesize proteins. Since insulin lowers blood sugar as it disposes of amino acids, eating a large amount of protein without carbohydrate can cause a sharp decrease in blood sugar. This leads to the release of adrenalin and cortisol, which raise the blood sugar. Adrenalin causes fatty acids to be drawn into the blood from fat stores, especially if the liver's glycogen stores are depleted, and cortisol causes tissue protein to be broken down into amino acids, some of which are used in place of carbohydrate. Unsaturated fatty acids, adrenaline, and cortisol cause insulin resistance.
A high quality protein such as egg, can cause a stress reaction, and fail to be fully used as protein, if it is eaten without carbohydrates.
http://raypeat.com/articles/articles/Glycemia%

Ah, problem solved.

What sugar intake in grams would you recommend to prevent this hypoglycemia.

I just took some protein and it caused anxiety for a few minutes then passed.
 
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kineticz

kineticz

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HDD said:
"There’s a special problem with the basis for diagnosing estrogen deficiency, because in the absence of anti-estrogen substances such as progesterone, the estrogen in the blood can go to a very low level, because the estrogen is staying inside cells, and progesterone knocks it out of cells, inactivates it, but causes it to appear in the blood stream on its way out the kidneys. So, in the absence of progesterone, doctors will measure a low level of serum estrogen, and prescribe it, even though, under that situation, it’s very likely that their tissues, breast and uterus in particular, are actually overloaded with a chronic supply of estrogen."

This is very interesting.

However, my progesterone on bloods is not low. 2.6nmol/l

On another forum, a moderator said pregnenolone for long periods can raise E1 and E3, but not E2.

My blood test was low E2, but I do feel as if estrogen is involved somewhere. I read that Vitamin E can lower Estrone. I get hypoglycemia if I take DIM.

The problem I'm having is that even with increased sugar, and T3, and better diet, protein etc, all sugar is doing is cutting off my adrenals, and my metabolism only ever goes so far before I get low blood sugar again. I'm still getting cataracts every now and then.

I'm finding my metabolism grinds down to a halt during sleep. It's very difficult getting going the next day.

I have to take very low doses of pregnenolone or I get adrenal suppression. I know Ray Peat is anti-ACTH but they do need some signalling and suppression is worse in my experience than excess.
 
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kineticz said:
I'm finding my metabolism grinds down to a halt during sleep. It's very difficult getting going the next day.

I get this and I have high estradiol and low estrone. Just something to consider.
 
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kineticz

kineticz

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Such_Saturation said:
kineticz said:
I'm finding my metabolism grinds down to a halt during sleep. It's very difficult getting going the next day.

I get this and I have high estradiol and low estrone. Just something to consider.

My estradiol is flat as a pancake.

Two markers that show this are my LH is through the roof, above top of the range. My prog is not low for a male.

Where I majorly screwed up and what brought me here is despite high LH, high progesterone and low estrogen E2, my prolactin was very high, as was my cortisol. My TSH was 3.0. I have low testosterone.

Guys, with all this emphasis on fighting adrenal stimulation, if you have trouble retaining and activating thyroid hormone, low adrenal status is a very bad place to be. High cortisol does not necessarily mean your adrenals are healthy - serotonin and prolactin directly stimulate the adrenal cortex independent of the pituitary.

Basically I was taking pregnenolone, aromatase inhibitors and DHT blockers at the same time (yes), and I gradually declined into a horrible state. Excess pregnenolone will downregulate your cortisol and DHEA, progressively leaving you worse off.

High LH diverts pregnenolone away from the adrenals, resulting in CAH. My blood results said 'suspected CAH' at the bottom and the endocrinologist didn't say a word.

I'm better than I was but like I say, my sex drive not very good, and I'm limp as a noodle down below unless I'm sexually stimulated. :cry: I still get obsessive intrusive thoughts, and cataracts, socially anxious, to name many symptoms.
 
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But was the estradiol actually measured?
 

tara

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kineticz said:
'Refined sugar favors conversion of tryptophan to serotonin causing a relative dopamine deficiency and acetylcholine deficiency, which causes disturbances in movement and memory'

I just read this page. It looks as though he attributes to estrogen insufficiency some symptoms thant Peat seems to attribute to estrogen excess and/or progesterone deficiency (eg menopausal hot flashes). Since this is Peat's area of particular expertise, I'm inclined to go on Peat's model so far.

He refers to refined sugars a few times on that page. I didn't read further about his approach, but I'm guessing the point about refined sugar for him would be the lack of sufficient accompanying micronutrients, eg potassium, magnesium, B-vitamins, to aid in its efficient metabolism? I think Peat is also keen on supplying adequate micronutrients, though he does seem to think it can be done alongside some limited refined sucrose, when better sugar sources are not available.
I guess excessive refined sugars without adequate B-vitamins, potassium, magnesium etc could be expected to cause some problems.
 

Peata

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kineticz said:
Peata said:
kineticz said:
HDD said:
Do you have a source?

http://www.drkaslow.com/html/premenstru ... romes.html

My estrogen is non-existent on blood tests and it's lists on progesterone excess and estrogen deficiency tell me that my depersonalised mood which still remains at some moments is due to norephiprene reduction. I think some estrogen is good for mood and focus.

Large doses of vitamin E are working spectacularly for my clarity and sex drive. This study says it boosts estrogen and lowers LDL cholesterol. High LDL cholesterol inhibits adrenal steroids. I also do not do well when consuming eggs. I get panic attacks.

Vitamin E is an estrogen antagonist.

http://raypeat.com/articles/articles/vitamin-e.shtml

According to the link, low doses antagonise estrogen, but high doses can increase it.

how much E do you take?
 

HDD

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kineticz said:
HDD said:
Eggs can cause hypoglycemia which symptoms are similar to panic attack.

Insulin release is also stimulated by amino acids such as leucine, and insulin stimulates cells to absorb amino acids and to synthesize proteins. Since insulin lowers blood sugar as it disposes of amino acids, eating a large amount of protein without carbohydrate can cause a sharp decrease in blood sugar. This leads to the release of adrenalin and cortisol, which raise the blood sugar. Adrenalin causes fatty acids to be drawn into the blood from fat stores, especially if the liver's glycogen stores are depleted, and cortisol causes tissue protein to be broken down into amino acids, some of which are used in place of carbohydrate. Unsaturated fatty acids, adrenaline, and cortisol cause insulin resistance.
A high quality protein such as egg, can cause a stress reaction, and fail to be fully used as protein, if it is eaten without carbohydrates.
http://raypeat.com/articles/articles/Glycemia%


Ah, problem solved.

What sugar intake in grams would you recommend to prevent this hypoglycemia.

I just took some protein and it caused anxiety for a few minutes then passed.


"To use the protein of 2 eggs efficiently it would be good to have a glass of milk and a large glass of orange juice." RP
 
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kineticz

kineticz

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Such_Saturation said:
kineticz said:
Such_Saturation said:
But was the estradiol actually measured?

E2 is Estradiol and was measured at less than 10.

Mine was between thirty and forty if I remember.

Excellent replies to this thread. Really appreciate the input guys and gals.

When I previously had blood drawn I was 36 and I have to say I was healthier and happier when E2 was not so low as it is now.
 

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