Study:Normal To High NaCl Intake Is Associated WithPsoriasis, CNS-Disorders,IL17

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These Data-Hamsters are unhinged,let them entertain us though.Allegedly excess NaCl and concomitant rise of Sodium sensing Glucocorticoid-Kinase1,Interleukine liberation,NFKB induction etc, is a major driver of inflammation.

Link To Full Study:https://www.researchgate.net/profil...athogenesis-of-neuropsychiatric-disorders.pdf



In the astronaut training(?) study that was also posted at rpf,the rise of inflammatory cytokines was 6-fold,supression of antiinflammatory pathways 4-fold.



My take is that Ray Peat is right on NaCl in hypothyroidism,but for semi-healthy peeps maybe there is risk involved.
the IL17-secreted-by-Th17-cells-cascade is pretty damn evil,and evil isnt aloud o.o..salt is pretty tasty though..
In Depression there is higher residual natrium in one study,IL17 antagonists are used in psoriasis,colitis i think..
IL17 is highly expressed in nervous tissue also,and sodium retention is increased in older age,i saw that sentiment in another one.
i know what the man has to say about salt,but this is new research,unknown to peat in his formative years.
Low Dose salt dosage would be 2-3g total Nacl,

Thoughts?


Abstract
Salt is an important macronutrient that plays pivotal roles in physiological
and pathophysiological conditions. High salt intake is an important cause of
hypertension, cardiovascular disease and stroke. However, recent investigations
uncovered the role of excessive salt intake in the induction of severe
inflammatory reactions through augmentation of T helper-17 pathway and
their inflammatory cytokines. In contrast, numerous studies have shown the
role of inflammation in the pathophysiology of neuropsychiatric disorders
(NPD). Here, it is hypothesized that high salt intake can increase the risk of
NPD through salt-derived neural inflammations. Therefore, this hypothesis
suggests that low-salt intake can decrease the risk of NPD. The present
review discusses the potential role of excessive salt intake in the pathophysiology
of NPD.
 

AlphaCog

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Salt intake is usually associated with modern processed foods(nitrates, excess fat).

Salt intake did not affect people who ate traditional preserved foods(potassium, low fat).
 
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rei

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Salt is an immune system booster, so salt deficiency has same "beneficial" mechanism as pufa, immune suppression. Psoriasis, all sorts of "autoimmune" disorders are "helped". Sorry, you are making the underlying problem worse by inhibiting the repair attempt.
 
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Tristan Loscha

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The thing is, that likely above-average healthy would-be-astronauts had all these immune derangements.
One Study,mouse model,had graft-VS-host self-tolerance
as its topic.

it was vertical axis:bodyweight[100g mouseweight],horizontal axis:[days to decline of health,0-40days].

mouse with low salt kept on trucking
at 100grams,0-to day40;salt-mouses had BW-reduction at day 20 to only 60grams...

its all about self-tolerance in "autoimmunity",and salt has the honorable
duty to initiate the infection cascade.thats how the body is doing it:it is no saltpoisoning,it is physiologic.the body iniates and maintains it by virtue of water control,tonicity.

the authoritarian,towering salt-dispenser is looking
like a hooligan to me.
 

AlphaCog

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Review of salt consumption and stomach cancer risk: Epidemiological and biological evidence
Salt intake is associated with stomach cancer.

Perhaps Warren Buffett got his colon cancer from salt intake. However he got at 69 after decades(No "rest" days, everyday is cheat day) of high sugar(coke), salt, ice cream, red meat, junk food(fudge and peanut brittle). Mildly active(walks to office with speed as reported by his bodyguard) and doesn't eat vegetables.

Salt seems to remove mucus, damage lining. Salt will help metabolize fat.
High-salt intake negatively regulates fat deposition in mouse
 
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If you want to post a study, please do. The OP is citing one person’s dumb opinion. It’s not a study. It’s not even a review.

Human studies of diet are on the whole unreliable to say the least. This isn’t a study, but in general I’m just saying that really only animal studies are worth anything when it comes to diet because human studies use surveys, recall, and have too many confounders that are hidden from the researchers either on purpose or due to oversight or impossibility of discovery.
 

Tristan Loscha

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If you want to post a study, please do. The OP is citing one person’s dumb opinion. It’s not a study. It’s not even a review.

Human studies of diet are on the whole unreliable to say the least. This isn’t a study, but in general I’m just saying that really only animal studies are worth anything when it comes to diet because human studies use surveys, recall, and have too many confounders that are hidden from the researchers either on purpose or due to oversight or impossibility of discovery.


Slight disagree.
it is an analytical mechanistic Review,and a study-review of 17 studies published on animal models,cellculture studies,and human intervention and observational studies.
"Summary of the results on the role of high salt intake in the induction of inflammation and autoimmunity",17 entries.
 

Tristan Loscha

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Titles:

"Severe neuropathology in EAE mouse model"
"Enhancement of macrophage activation and infiltration into the mouse brain"
"Delayed wound healing in mouse model"
"Increased activities of pulmonary macrophage and their pro-inflammatory cytokines in LPS-
induced lung injury in mouse models"

"increased Ab(amyloid beta) levels in neural cells after NaCl treatment"
"Suppresses the capacity of neural cells to clear Ab and reduces apolipoprotein E level"

"2.75- to 3.95-fold increase in disease activity of MS patients with medium to high salt intakes
compared with the low-intake group"
"increased number of monocytes in healthy humans with high-salt diet than healthy humans
with a low dietary salt intake
Increased IL-10 and decreased IL-6 and IL-23 levels after reduced dietary salt intake"
 
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