Studies Say Minoxidil Is Anti-androgenic

[TheBeard]

What the...?

I thought we had been told all along that Minoxidil worked in totally different pathways and left androgen receptors and 5ar unaffected.

These would suggest we’ve been lied to:

Minoxidil Acts as an Antiandrogen: A Study of 5α-reductase Type 2 Gene Expression in a Human Keratinocyte Cell Line. - PubMed - NCBI

Minoxidil may suppress androgen receptor-related functions

 

[TheBeard]

@haidut @Amazoniac

Am I reading those correctly?

 

[RisingSun]

The way I see it, you are reading this right.

Yet another example of (un)voluntary side effect dissimulation by the pharma industry.

They probably also genuinely didn’t know and found out by chance that it possesses anti-androgenic activity.

 

[Sheik]

Consider that minoxidil works for men trying to grow facial hair. I don't think AA is the main mechanism of action.

I wish minox worked for me but the side effects are horrible.

 

[johnwester130]

If DHT causes baldness, why are they taking somethiung to increase ciruclation to the scalp ?

Finasteride actually blocks 11 hormones, so makes you wonder.

 

[haidut]

@haidut @Amazoniac

Am I reading those correctly?

Yep, and not surprised as it is known to give men ED. And to think that some doctors even prescribe topical Minoxidil as treatment of ED just makes me shudder...
http://www.ijmrps.com/Issues PDF/Vol.4/May-2017/5.pdf
https://www.askapatient.com/viewrating.asp?drug=20834&name=ROGAINE+EXTRA+STRENGTH+(FOR+MEN)

 

[TheBeard]

And then there is this:

Minoxidil increases 17 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase activity of cultured human dermal papilla cells from balding scalp. - PubMed - NCBI

Minoxidil increases 17 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase activity of cultured human dermal papilla cells from balding scalp.

 

[TheBeard]

The above study contradicts this one:

Steroidogenic enzymes in skin. - PubMed - NCBI

which states that: "biologically inactive C19-steroids produced by glandular and peripheral tissues may also feed into the scalp skin production of dihydrotestosterone by the local expression of reductive 17b-hydroxysteroid dehydrogenase, oxidative 3a-hydroxysteroid dehydrogenase, and 3b-hydroxysteroid dehydrogenase enzymes. Aberrant expression of one or more of these enzymes, could conceivably result in increased scalp dihydrotestosterone levels, and possibly, acceleration of the balding process in genetically predisposed men and women."

 

[Julles]

The above study contradicts this one:

Steroidogenic enzymes in skin. - PubMed - NCBI

which states that: "biologically inactive C19-steroids produced by glandular and peripheral tissues may also feed into the scalp skin production of dihydrotestosterone by the local expression of reductive 17b-hydroxysteroid dehydrogenase, oxidative 3a-hydroxysteroid dehydrogenase, and 3b-hydroxysteroid dehydrogenase enzymes. Aberrant expression of one or more of these enzymes, could conceivably result in increased scalp dihydrotestosterone levels, and possibly, acceleration of the balding process in genetically predisposed men and women."

Possibly?? Really objective. Yeah, science b****! Assumptions?

I really hate these studies... the guy who wrote it should be smacked in the face with the paper rolled.