Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

[Jam]

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2 - Nature

The B.1.1.529/Omicron variant of SARS-CoV-2 is resistant to neutralization by serum not only from patients who recovered from COVID-19, but also from individuals vaccinated with one of the four widely used COVID-19 vaccines.

www.nature.com

The Omicron (B.1.1.529) variant of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) was only recently detected in southern Africa, but its subsequent spread has been extensive, both regionally and globally1. It is expected to become dominant in the coming weeks2, probably due to enhanced transmissibility. A striking feature of this variant is the large number of spike mutations3 that pose a threat to the efficacy of current COVID-19 (coronavirus disease 2019) vaccines and antibody therapies4. This concern is amplified by the findings from our study. We found B.1.1.529 to be markedly resistant to neutralization by serum not only from convalescent patients, but also from individuals vaccinated with one of the four widely used COVID-19 vaccines. Even serum from persons vaccinated and boosted with mRNA-based vaccines exhibited substantially diminished neutralizing activity against B.1.1.529. By evaluating a panel of monoclonal antibodies to all known epitope clusters on the spike protein, we noted that the activity of 17 of the 19 antibodies tested were either abolished or impaired, including ones currently authorized or approved for use in patients. In addition, we also identified four new spike mutations (S371L, N440K, G446S, and Q493R) that confer greater antibody resistance to B.1.1.529. The Omicron variant presents a serious threat to many existing COVID-19 vaccines and therapies, compelling the development of new interventions that anticipate the evolutionary trajectory of SARS-CoV-2.

 

[lvysaur]

I remember reading somewhere that vaxees had antibodies not only to the spike protein, but also to the nucleocapsid. If this is true, doesn't it mean that the virus is literally putting itself together after you get vaccinated?

And while this has its own set of concerns, wouldn't it also theoretically mean that any unique threat from omicron is overblown, even for the vaccinated, since they also got exposure to the whole-virus?

 

[Jam]

I remember reading somewhere that vaxees had antibodies not only to the spike protein, but also to the nucleocapsid. If this is true, doesn't it mean that the virus is literally putting itself together after you get vaccinated?

And while this has its own set of concerns, wouldn't it also theoretically mean that any unique threat from omicron is overblown, even for the vaccinated, since they also got exposure to the whole-virus?

All COVID-19 vaccines encode the spike protein only.

 

[ThinPicking]

Why would anyone care about this.

No one should be taking these injections. Current or modified.

A healthy body renders a healthy immune response to any pathogen.

 

[David PS]

Evidence for a mouse origin of the SARS-CoV-2 Omicron variant

 

[Perry Staltic]

.

 

[Gustav3Y]

Evidence for a mouse origin of the SARS-CoV-2 Omicron variant

I am not sure, do people on this forum actually disregard Chinese studies regarding SARS-CoV-2?

 

[Fred]

Literally NONE of these observations matter until the PCR test is confirmed to be accurate as a diagnostic tool. This has never been done, and obviously never will be done, because that would ruin the scam. And due to the additional SGTF issue with PCR/Omicron, it's possible that they're not even detecting viral material anymore, so of course it would evade the immune system.

 

[IROM]

I remember reading somewhere that vaxees had antibodies not only to the spike protein, but also to the nucleocapsid. If this is true, doesn't it mean that the virus is literally putting itself together after you get vaccinated?

And while this has its own set of concerns, wouldn't it also theoretically mean that any unique threat from omicron is overblown, even for the vaccinated, since they also got exposure to the whole-virus?

Yeh I think they deliberately did this. Previous findings for Sars-Cov-1 specifically concluded only an S2 protein subunit like proposed Xiamen Innovax vaccine should be used. Including S1 subunit increases chances of VAED.