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StressNon - Custom Liquid Supplement With Pregnenolone

Discussion in 'IdeaLabs' started by haidut, Apr 7, 2014.

  1. Dagwood

    Dagwood Member

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    Hi Haidut. I'm having trouble deciding what to get. I'm pretty sure about getting Estroban and perhaps Energin, however, I'm having trouble deciding between Stressnon (pregnenolone) and Pansterone (pregnenolone and DHEA). Since pregnenolone can convert into DHEA I wonder if it could be redundant to get Pansterone. In addition, I believe Ray Peat said that excess DHEA would convert into estrogen, whereas excess pregnenolone would have no effect. Is there any chance that the pregnenolone wouldn't be able to convert into DHEA? I believe I probably could use some DHEA but I don't want to take too much and I'm not sure it would be necessary if some of the pregnenolone will convert into it. Furthermore, it might be possible that I need more pregnenolone than DHEA but if they came in a mixture I might have to take too little pregnenolone for fear of taking too much DHEA. I'm mostly trying to get rid of my premature grey hair which I know is silly but it's important to me lol. I read that Ray said DHEA could help with grey hair (whether topically or orally I don't remember). Oh, I'm a male by the way. Anyway, can you help me sort this out? Should I just get the Stressnon and forget about the Pansterone? Thanks.
     
  2. OP
    haidut

    haidut Member

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    I think for males, Pansterone would be more appropriate since it tends to have both an anti-stress and androgenic effect. If you stick to 1 dose or less of Pansterone daily, the 5mg of DHEA that provides is highly unlikely to convert into estrogen. And many people using Pansterone find that they get best effects from taking even less daily. Given that the supplement is liquid you can control how much DHEA you get but if you stay under 5mg per dose you should be safe. StressNon is more or less a neutral supplement and can be used in pretty much any dose by both sexes.
    I hope that answers your questions.
     
  3. Dagwood

    Dagwood Member

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    Ok. Thank you haidut.
     
  4. jaa

    jaa Member

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    I couldn't find a Stressnon thread, so I decided to post this here since the products are similar?

    A 4-5mo old Stressnon bottle I have that's almost emptied has a weird solid crystal formation inside it. Is this from a reaction between ingredients? Can I safely consume it. The air temperature in my home is usually 10-15C.
     
  5. OP
    haidut

    haidut Member

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    It's just the pregnenolone that has crystalized. Pregnenolone is not very soluble in any solvent really and even in DMSO. So, at lower temps it may crystalize. You can put the bottle in a warmer environment where the temps are 20C degrees, wait for the bottle to warm up and them just shake it. Even if the liquid is still cloudy it will still absorb.
     
  6. jaa

    jaa Member

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    Thanks!
     
  7. firebreather

    firebreather Member

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    Haidut, Am I reading the label wrong on the bottle?

    The post says that one serving contains 100mg of pregnenolone per serving and 100IU - 200IU of vitamin E.

    But the bottle says that one serving contains just 20mg of pregnenolone and nothing about vitamin E.
     
  8. OP
    haidut

    haidut Member

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    The supplement changed. The original one had 100mg pregnenolone per dose and it was dissolved in olive oil and tocopherol. But it did not dissolve well and was clogging the bottle. After doing research on DMSO and how effective it is in increasing steroid absorption, we changed it to DMSO and 20mg pregnenolone per dose. The studied show that transdermal route of applying steroids dissolved in DMSO is equivalent to about 10 times higher dose oral.
    Enhanced Bioavailability And Tissue Effects Of Steroids Dissolved In Dmso
    DMSO makes transdermal steroid absorption close to 100%

    Thanks for bringing it up, I need to change the original post.
     
  9. firebreather

    firebreather Member

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    Ok great. Thank you for clarifying
     
  10. Kennya

    Kennya Member

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    Haidut what's the overall consensus on dosing the Stressnon so far? Is most everyone doing 1 or 2 drops per day or dose like Pansterone and Tyromax, because of the DMSO potentiation?
     
  11. OP
    haidut

    haidut Member

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    I don't know what the consensus is since there is really no established optimal dose for everybody. But the equivalence should be roughly 1 : 10, so 10mg topical StressNon should be equivalent to 100mg oral pregnenolone.
    [Edited to show ratio instead of smiley - tara]
     
  12. Kennya

    Kennya Member

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    Thanks, much appreciated
     
  13. OP
    haidut

    haidut Member

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    I just wanted to post this for everybody using or thinking of ordering StressNon.
    We are now using an odor-free DMSO as a solvent for the steroids and this type of DMSO also seems dramatically lower the incidence of skin irritation as well.
     
  14. Sheila

    Sheila Member

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    Haidut,
    Thank you for all your hard work and sharing your knowledge, suggestions, ideas so freely, it is much appreciated.
    I know a 14 yo, pre-puberty boy with brain damage and slow metabolism whom Dr Peat has suggested try pregnenolone and thyroid. I am fairly familiar now with results and combinations of such approaches, how to monitor etc.
    However, i am not sure whether StressNon or Pansterone would be best to start with, do you have a preference? Risk remains with me, merely please if you have a view.
    Many thanks
    Sheila
     
  15. OP
    haidut

    haidut Member

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    Probably a higher dose oral pregnenolone, maybe 100mg daily, combined with topical Pansterone in doses of no more than 8 drops daily. At least that's what I would try.
     
  16. Sheila

    Sheila Member

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    Dear Haidut
    Many thanks, I appreciate your thoughts.
    Sheila
     
  17. Makrosky

    Makrosky Member

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    Make sure the boy is well fed (lots of carbs) and watch out for possible conversion of pregnenolone to stress hormones. In my personal experience if I take PREG when I'm angry/stressed/serotonergic it can easily convert to more stress hormones. If I take it when I'm ok and relaxed or some hours before I know some stress is gonna hit me, then it does all the good that plus it lasts to the next day. Also, sometimes PREG can give irritability (some had hypothesized it's because allopregnenolone) and I found it depends a lot on the dosage and the beforementioned stuff. So watch out for this kind of things. My personal experience, strictly. Good luck!
     
  18. Sheila

    Sheila Member

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    Thank you Makrosky, I appreciate your input. Best regards, Sheila
     
  19. T-3

    T-3 Member

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    I just ordered from idealabs. FYI, it took quite some searching to find a link to the online store. For example searching "buy pansterone" on this site does not produce a direct link to the store. Looking forward to trying out these terrific looking products, thanks!
     
  20. OP
    haidut

    haidut Member

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    The link to the store is in my signature and thus in every single one of my posts. Googling "buy pansterone" should get you to the right place as well. The forum is not just a venue for my supplements, and I would not expect it to be completely focused on making it too easy to find my supplements :):
     
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