Stress At Work Increases Risk For Certain Cancers

[haidut]

I suspect work stress increases risk for all cancers but that would be too political of a study to conduct. For now, we can say that it at least increase risk for GI and bladder cancers.

ScienceDirect

"...Employment in at least one stressful job was associated with increased odds of cancers of the lung (OR = 1.33, 95% CI: 1.01–1.75), colon (OR = 1.51, 95% CI: 1.15–1.98), bladder (OR = 1.37, 95% CI: 1.03–1.81), rectal (OR = 1.52, 95% CI: 1.10–2.10), and stomach (OR = 1.53, 95% CI: 1.08–2.15). A duration-response trend was found for cancers of the lung, colon, rectum, stomach, and for NHL. Subjects reported changes in stress level over their career. Perceived stress was ascribed to several sources, including high demand and time pressure, financial issues, job insecurity, and hazardous conditions."

 

[DaveFoster]

@haidut

This is probably a very general question, but what do you think would be helpful for people who have stressful jobs and who are trying to navigate towards a more creative outlet?

Dr. Peat has mentioned pregnenolone, and coffee is certainly used, but is there anything else that can particularly counter the negative hormonal effects of a desk-job?

 

[haidut]

@haidut

This is probably a very general question, but what do you think would be helpful for people who have stressful jobs and who are trying to navigate towards a more creative outlet?

Dr. Peat has mentioned pregnenolone, and coffee is certainly used, but is there anything else that can particularly counter the negative hormonal effects of a desk-job?

Peat has probably seen this study on pregnenolone
Pregnenolone Can Stop Habitual Behavior

I like vitamin B6 and B1. B6 is a glucocorticoid antagonist and when taken with enough protein will increase dopamine synthesis. B1 increases serotonin disposal and inhibits dopamine reuptake. Steve Jobs took massive doses when he was experimenting with LSD and said both were about equally effective as idea stimulators, but B1 did not have the "trip" effect which Jobs thought was key to breaking out of habit. The adamantane derivates are great anti-stress and pro-creativity tools. Theanine works as well, but I take it at night to not make me sleepy during the day.
Finally, just getting out of the office around lunch time and crossing streets "randomly" depending on which light on the corner turns green first is also a great tool for me. There is something very habit breaking about doing things based on the "perceive, think, act" paradigm based on input from the environment that is not under your control vs. sitting in an office and analyzing life to stupor.

 

[Drareg]

Peat has probably seen this study on pregnenolone :)
Pregnenolone Can Stop Habitual Behavior

I like vitamin B6 and B1. B6 is a glucocorticoid antagonist and when taken with enough protein will increase dopamine synthesis. B1 increases serotonin disposal and inhibits dopamine reuptake. Steve Jobs took massive doses when he was experimenting with LSD and said both were about equally effective as idea stimulators, but B1 did not have the "trip" effect which Jobs thought was key to breaking out of habit. The adamantane derivates are great anti-stress and pro-creativity tools. Theanine works as well, but I take it at night to not make me sleepy during the day.
Finally, just getting out of the office around lunch time and crossing streets "randomly" depending on which light on the corner turns green first is also a great tool for me. There is something very habit breaking about doing things based on the "perceive, think, act" paradigm based on input from the environment that is not under your control vs. sitting in an office and analyzing life to stupor.

Never knew Steve jobs was high dosing B1 and B6 ,what was his dose of B1? He never stumbled with memory on stage or interviews from what I can recall,always seemed articulate and well balanced.

 

[DaveFoster]

Peat has probably seen this study on pregnenolone :)
Pregnenolone Can Stop Habitual Behavior

I like vitamin B6 and B1. B6 is a glucocorticoid antagonist and when taken with enough protein will increase dopamine synthesis. B1 increases serotonin disposal and inhibits dopamine reuptake. Steve Jobs took massive doses when he was experimenting with LSD and said both were about equally effective as idea stimulators, but B1 did not have the "trip" effect which Jobs thought was key to breaking out of habit. The adamantane derivates are great anti-stress and pro-creativity tools. Theanine works as well, but I take it at night to not make me sleepy during the day.
Finally, just getting out of the office around lunch time and crossing streets "randomly" depending on which light on the corner turns green first is also a great tool for me. There is something very habit breaking about doing things based on the "perceive, think, act" paradigm based on input from the environment that is not under your control vs. sitting in an office and analyzing life to stupor.

I took about a gram of pregnenolone yesterday, and it removed all feelings of isolation and the urge to go on Tinder, look at porn, masturbate, or rather pursue starchy comfort foods.

I wasn't aware that Steve Jobs took B vitamins! I remember watching the documentary on his life (with Ashton Kutcher), and I idolized the guy; he seemed to have the same values as myself, but I'm well-aware that he was a very angry person into his middle-age (and somewhat OCD and perfectionist.)