I asked Life Extension whether it was a good idea to store pregnenolone in the freeze for a few months to keep it better. Their response:
Pregnenolone can be stored in the freezer or refrigerator for months before the bottle is opened. However, once the bottle has been opened, it should be kept in a cool, dry place. The condensation that occurs when a supplement is taken out of the refrigerator and then put back in, can negatively affect the quality of the product.