Stomach growing

[iLoveSugar]

I've read around a bit, but am curious as to what caues the stomach to grow, while continuing to maintain weight. I gained quite a bit of weight, but have maintained this 200lb over the past couple of years. The odd part is, my stomach is the main thing growing. I went from a medium in shirts, and pretty much right past large to an extra large. What's likely responsible?

 

[gaze]

fatty liver

 

[iLoveSugar]

fatty liver

What does one do for this?

 

[gaze]

What does one do for this?

there's a million different opinions on this. the peat thinking would be to lower endotoxin, eat fruits, keep fats lowish (around 60g) a day, use magnesium and vitamin b1, caffeine, small doses of aspirin, vitamin D, calcium, choline (from egg yolks). there's debate on how much fructose someone should eat with a fatty liver, how much fat they should eat, how much protein, etc. a lot of people do not feel good on a high sugar low starch diet, it gives them liver pains. for other people high starch causes endotoxins. other people get liver pains from excessive dairy. a lot of things are individual. i would say the number 1 rule is to lower intestinal inflamation. but of course, it's way easier said than done. especially when every food causes inflamation for some people

 

[Sefton10]

i would say the number 1 rule is to lower intestinal inflamation

Bingo

 

[LLight]

High fluid quantity, low osmolyte (betaine) consumption.
Low fluid could tend to increase the activation of protective transcription factors in the liver (LXR, FXR) and gut.
Osmolytes, minerals and vitamins allow you to sustain the osmotic stress.

 

[youngsinatra]

I think most people have some sort of NAFLD and it is not that easy to find out if you have it - liver values don't necessary need to be elevated. In the US the estimated prevalence of NAFLD is around 25-30%.

Do you consume any choline-rich foods like eggs or red meat? Choline deficiency is known to directly cause NAFLD in parenteral nutrition. (IV nutrition)

 

[Rafael Lao Wai]

High fluid quantity, low osmolyte (betaine) consumption.
Low fluid could tend to increase the activation of protective transcription factors in the liver (LXR, FXR) and gut.
Osmolytes, minerals and vitamins allow you to sustain the osmotic stress.

Do you supplement betaine, or do you try to get enough from food?

 

[LLight]

I supplement betaine as I've found a supposedly pure supplement (I empty the capsule in some food).
I believe betaine has low toxicity and could be lowered in food produced by modern agricultural standards (betaine is anti-stress in plants and I believe plants are less stressed to optimize produced volumes).

Dietary betaine and inflammation

We read with interest the article by Detopoulou et al (1) that reported dietary choline and betaine intakes and associations with inflammatory markers in health

academic.oup.com

We would also like to make the point that the level of betaine in the diet is affected by the source of the food. Betaine is also a plant osmoprotectant and cryoprotectant, and the level of betaine in plants may be significantly different depending on the conditions in which they are grown.

Betaine (trimethylglycine, an osmolyte) really seems like a wonder nutrients:

Betaine in Inflammation: Mechanistic Aspects and Applications

Betaine is known as trimethylglycine and is widely distributed in animals, plants, and microorganisms. Betaine is known to function physiologically as an important osmoprotectant and methyl group donor. Accumulating evidence has shown that betaine has ...

www.ncbi.nlm.nih.gov

Betaine is a positive regulator of mitochondrial respiration - PubMed

Betaine protects cells from environmental stress and serves as a methyl donor in several biochemical pathways. It reduces cardiovascular disease risk and protects liver cells from alcoholic liver damage and nonalcoholic steatohepatitis. Its pretreatment can rescue cells exposed to toxins such as...

pubmed.ncbi.nlm.nih.gov

Betaine enhances the cellular survival via mitochondrial fusion and fission factors, MFN2 and DRP1

Betaine is a key metabolite of the methionine cycle and known for attenuating alcoholic steatosis in the liver. Recent studies have focused on the protection effect of betaine in mitochondrial regulation through the enhanced oxidative phosphorylation ...

www.ncbi.nlm.nih.gov

Betaine attenuates LPS-induced downregulation of Occludin and Claudin-1 and restores intestinal barrier function - BMC Veterinary Research

Background The intestinal epithelial barrier, which works as the first line of defense between the luminal environment and the host, once destroyed, it will cause serious inflammation or other intestinal diseases. Tight junctions (TJs) play a vital role to maintain the integrity of the...

bmcvetres.biomedcentral.com

The effects of 14-week betaine supplementation on endocrine markers, body composition and anthropometrics in professional youth soccer players: a double blind, randomized, placebo-controlled trial - Journal of the International Society of Sports Nutr

Objective Betaine supplementation may enhance body composition outcomes when supplemented chronically during an exercise program. The purpose of this study was to evaluate the effect of betaine supplementation on development-related hormones, body composition, and anthropometrics in professional...

jissn.biomedcentral.com

Dietary Betaine Addition Promotes Hepatic Cholesterol Synthesis, Bile Acid Conversion, and Export in Rats

It is widely reported how betaine addition regulates lipid metabolism but how betaine affects cholesterol metabolism is still unknown. This study aimed to investigate the role of betaine in hepatic cholesterol metabolism of Sprague-Dawley rats. Rats were ...

www.ncbi.nlm.nih.gov

Betaine treatment protects liver through regulating mitochondrial function and counteracting oxidative stress in acute and chronic animal models of hepatic injury - PubMed

Betaine is a derivative of the amino acid glycine widely investigated for its hepatoprotective properties against alcoholism. The protective properties of betaine in different other experimental models also have been documented. On the other hand, the exact cellular mechanism of cytoprotection...

pubmed.ncbi.nlm.nih.gov

Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise - PubMed

Our aim was to examine the effect of betaine supplementation on selected circulating hormonal measures and Akt muscle signaling proteins after an acute exercise session. Twelve trained men (age 19.7 ± 1.23 years) underwent 2 weeks of supplementation with either betaine (B) (1.25 g BID) or...

pubmed.ncbi.nlm.nih.gov

Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women - PubMed

High plasma homocysteine is a risk for cardiovascular disease and can be lowered through supplementation with 6 g/d of betaine. However, dietary intake of betaine is approximately 0.5-2 g/d. Therefore, we investigated whether betaine supplementation in the range of dietary intake lowers plasma...

pubmed.ncbi.nlm.nih.gov

Effects of betaine on performance and body composition: a review of recent findings and potential mechanisms - PubMed

Betaine is a methyl derivative of glycine first isolated from sugar beets. Betaine consumed from food sources and through dietary supplements presents similar bioavailability and is metabolized to di-methylglycine and sarcosine in the liver. The ergogenic and clinical effects of betaine have...

pubmed.ncbi.nlm.nih.gov

Betaine supplementation is associated with the resilience in mice after chronic social defeat stress: a role of brain-gut-microbiota axis - PubMed

These findings suggest that betaine supplementation contributed to resilience to anhedonia in mice subjected to CSDS through anti-inflammation action. Therefore, it is likely that betaine could be a prophylactic nutrient to prevent stress-related psychiatric disorders.

pubmed.ncbi.nlm.nih.gov

Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice

Identifying markers of human insulin resistance may permit development of new approaches for treatment and prevention of type 2 diabetes. To this end, we analyz

diabetes.diabetesjournals.org

Investigation of betaine as a novel psychotherapeutic for schizophrenia

 

[Rafael Lao Wai]

I supplement betaine as I've found a supposedly pure supplement (I empty the capsule in some food).
I believe betaine has low toxicity and could be lowered in food produced by modern agricultural standards (betaine is anti-stress in plants and I believe plants are less stressed to optimize produced volumes).

Dietary betaine and inflammation

We read with interest the article by Detopoulou et al (1) that reported dietary choline and betaine intakes and associations with inflammatory markers in health

academic.oup.com

Interesting. Thanks.

I've read around a bit, but am curious as to what caues the stomach to grow, while continuing to maintain weight. I gained quite a bit of weight, but have maintained this 200lb over the past couple of years. The odd part is, my stomach is the main thing growing. I went from a medium in shirts, and pretty much right past large to an extra large. What's likely responsible?

Now that I'm thinking about it, doesn't cortisol cause weight gain in the midsection?

 

[Blaze]

there's a million different opinions on this. the peat thinking would be to lower endotoxin, eat fruits, keep fats lowish (around 60g) a day, use magnesium and vitamin b1, caffeine, small doses of aspirin, vitamin D, calcium, choline (from egg yolks). there's debate on how much fructose someone should eat with a fatty liver, how much fat they should eat, how much protein, etc. a lot of people do not feel good on a high sugar low starch diet, it gives them liver pains. for other people high starch causes endotoxins. other people get liver pains from excessive dairy. a lot of things are individual. i would say the number 1 rule is to lower intestinal inflamation. but of course, it's way easier said than done. especially when every food causes inflamation for some people

Very well stated............ great advice, very thorough response.

 

[akgrrrl]

that bellyfat is a shaggy curtain attached directly over the stomach organ called the omentum, that is largely cortisol induced. Your ab muscles are stretched out over the top of the curtain, on the outside. Its a worthwhile discovery to determine all the ways we produce cortisol.

 

[Rick K]

I've read around a bit, but am curious as to what caues the stomach to grow, while continuing to maintain weight. I gained quite a bit of weight, but have maintained this 200lb over the past couple of years. The odd part is, my stomach is the main thing growing. I went from a medium in shirts, and pretty much right past large to an extra large. What's likely responsible?

Pregnant? :)