Stenabolic

[LeeLemonoil]

Touted as a SARM but isn't since it does not act in any way on nuclear steroid receptors. Modulated parameters seem "peaty".


9 Amazing Effects of SR9009 (Stenabolic) + Mechanisms - Selfhacked


Mechanism of Action
All the effects observed for SR9009 derive from REV-ERB (NR1D1, NR1D2) activation in the body.

REV-ERB affects the circadian behavior of mice, altering their activity and sleep patterns [R].

Besides its effect on the circadian rhythm (suppression of BMAL1 production), REV-ERB affects many other functions related to energy production [R, R].

REV-ERB is mainly found in liver, muscle, and fat tissue:

• Liver: REV-ERB affects the rhythm of 90% of the about 900 genes under circadian control in mice liver. It turns off the genes that produce glucose without altering insulin sensitivity. It also turns on genes that generate new fat cells and reduces the inflammatory response (by affecting macrophage production) [R, R, R, R].
• Muscles: REV-ERB promotes the burning of fat, increases the activity of mitochondria, and promotes the generation of new while decreasing the destruction of old mitochondria [R].
• Fat cells: REV-ERB turns off the genes responsible for storing fat and decreases triglyceride production [R].

In animal and cell studies, SR9009:

• Increased oxygen consumption [R]
• Decreased generation of new fat cells in the liver [R]
• Decreased production of cholesterol and bile acids in the liver [R]
• Increased the number of mitochondria in muscle [R]
• Increased glucose and fatty acid use in muscle [R]
• Decreased fat storage [R]

 

[Tom K]

My understanding is that SR9009 is difficult to absorb orally. Has your research co firmed/denied that component?

 

[Tbone107]

Touted as a SARM but isn't since it does not act in any way on nuclear steroid receptors. Modulated parameters seem "peaty".


9 Amazing Effects of SR9009 (Stenabolic) + Mechanisms - Selfhacked


Mechanism of Action
All the effects observed for SR9009 derive from REV-ERB (NR1D1, NR1D2) activation in the body.

REV-ERB affects the circadian behavior of mice, altering their activity and sleep patterns [R].

Besides its effect on the circadian rhythm (suppression of BMAL1 production), REV-ERB affects many other functions related to energy production [R, R].

REV-ERB is mainly found in liver, muscle, and fat tissue:

• Liver: REV-ERB affects the rhythm of 90% of the about 900 genes under circadian control in mice liver. It turns off the genes that produce glucose without altering insulin sensitivity. It also turns on genes that generate new fat cells and reduces the inflammatory response (by affecting macrophage production) [R, R, R, R

 

[LeeLemonoil]

Merits the quote

 

[Mauritio]

Rev -erb is interesting . Its strange ei never even heard of it. It's also an tlr4 antagonist !

 

[koreus]

My understanding is that SR9009 is difficult to absorb orally. Has your research co firmed/denied that component?

A related compound with all of the same effects SR9011 is bioavailable transdermally in DMSO.