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Ssri (sertraline) And Coronary Artery Atherosclerosis

miko

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"Our findings suggest that long-term treatment with this drug promotes coronary artery atherosclerosis in non-human primates," Shively said. "This may be clinically significant for people because almost a quarter of middle-aged women in the United States take antidepressants, the most prescribed of which are SSRIs."

http://www.tasnimnews.com/english/Home/Single/703757

"Effects of Long-Term Sertraline Treatment and Depression on Coronary Artery Atherosclerosis in Premenopausal Female Primates"
 
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"Our findings suggest that long-term treatment with this drug promotes coronary artery atherosclerosis in non-human primates," Shively said. "This may be clinically significant for people because almost a quarter of middle-aged women in the United States take antidepressants, the most prescribed of which are SSRIs."

Common Antidepressant Increased Coronary Atherosclerosis in Animal Model

"Effects of Long-Term Sertraline Treatment and Depression on Coronary Artery Atherosclerosis in Premenopausal Female Primates"

Was just researching this and read through the study above. It's worth noting that sertraline is commonly prescribed @ 50 - 100mg.

These monkeys received 20mg/kg @ about 4kg bodyweight each.

Conversion to humans gives a dose in the range of 560 - 800mg for an 80kg human. Pretty high. Low human doses may not present the same dangers
 
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