Ssri Causing Brain Micro Bleeds

Spondive

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Antidepressants Linked to Cerebral Microbleeds

The use of antidepressants is linked to an increased risk for the development of first-time cerebral microbleeds, results of a longitudinal study showed looking at 2,500 people over 45. "In this population-based study, we found that antidepressant use was associated with an increased risk of incident first-ever microbleeds after 4 years of follow-up," said author Bruno H. Stricker, MMed, PhD, Erasmus University Medical Center, in Rotterdam, the Netherlands. "Association's were similar for different categories of antidepressant users and persisted after adjusting for depressive symptoms and cardiovascular risk." On the basis of brain MRI taken at baseline and at a mean interval of 3.9, the overall incidence of cerebral microbleeds was determined to be 3.7%.

In categorizing antidepressants according to affinity for the serotonin transporter, use of antidepressants that had intermediate serotonin affinity was associated with the highest risk for microbleeds. Nonsignificant differences were seen after adjusting for duration and dose of antidepressant treatment. The increased risk for microbleeds with SSRI's is speculated to be linked to a mechanism similar to that of antiplatelet drugs, in which SSRI's "block the reuptake of serotonin by platelets and decrease serotonin platelet concentration, which may lead to impaired aggregation and prolonged bleeding times" the authors add. However, the finding that the risk for microbleeds is similar with SSRI's and non-SSRI's suggests that the affinity of the serotonin transporter may not play a role, and another unidentified mechanism may explain the effect. The authors add that an important consideration is the possibility of a "reverse causality," in which the microbleed itself leads to antidepressant use.

The study's findings of no significant differences in risk between antidepressant categories was especially notable. "This is quite surprising and a little troubling. One would have expected to see a much stronger risk for SSRI's than for non-SSRI's, given the putative mechanism underlying the association between antidepressants and bleeding."The fact that both SSRI's and non-SSRI antidepressants were associated with bleeding suggests that we either have the mechanism wrong or there is confounding at play," said experts.
 
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So is SSRE going to cause microclots?
 
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Spondive

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I don't have the exact study but I don't think SSRE were studied..
 
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Spondive

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Yes... My point of sending was the author doesn't want to implicate serotonin, but it may still be the cause... So a study on Ssri vs ssre maybe interesting unadulterated
 

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