LeeLemonoil
Member
- Joined
- Sep 24, 2016
- Messages
- 4,265
This study:
Activation of an Olfactory Receptor Inhibits Proliferation of Prostate Cancer Cells
identified the common natural terpene Beta-Ionone, which sees wide application as an aromachemical in perfumes and as a flavouring agent, as a major ligand and agonist of an olfactive receptor (OR) in prostrate cancer cells. The natural and physiological occuring ligand/agonist is actually DHT - both substances stop the proliferation of the cancer cells and are therefore anti-cancerous in the prostrate.
The study proclaims that ß-Ionone has a chemical structure that is very similar to that of DHT.
- If ß-Ionone can activate an OR which physiologicaly is only designed to be activated by DHT it may be feasible that ß-Ionone can bind to other types of receptors that DHT binds to as well, probably through molecular conformation. Since ß-Ionone is a terpene which is highly volatile (due to low molecular mass) and fat-soluble, it is easily absorbed through various tissues and will certainly also reach the brain via inhalation alone.
I'm interested if inhalation of the substance will result in some positive mental effects that some ascribe to DHT in the CNS.
It's a very cheap and unrestricted substance which can be obtained here for example:
Beta Ionone
2ml cost 2USD - it should be diluted with alcohol to 10% or even 1% for anyody interested in testing it as an inhalation agent or sublingualy, so 2ml are plenty.
In the above mentioned study, the authors also indictae that the only other ligand to the prostrate specific OR/DHT receptor they identified is
1,4,6-Androstatriene-3,17-dione - Wikipedia
a potent aromatase inhibitor.
And this study found an OR-receptor activated by ß-Ionone in melatocytes in the skin:
Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes
Does anybody konow about DHT effects on melanocytes or melanin expression?
So it is certainly an interesting compound, ß-Ionone and used in it's natural and synthetic forms since centuries/decades respectively, meaning it is probably a safe substance, granted for internal use even.
Activation of an Olfactory Receptor Inhibits Proliferation of Prostate Cancer Cells
identified the common natural terpene Beta-Ionone, which sees wide application as an aromachemical in perfumes and as a flavouring agent, as a major ligand and agonist of an olfactive receptor (OR) in prostrate cancer cells. The natural and physiological occuring ligand/agonist is actually DHT - both substances stop the proliferation of the cancer cells and are therefore anti-cancerous in the prostrate.
The study proclaims that ß-Ionone has a chemical structure that is very similar to that of DHT.
- If ß-Ionone can activate an OR which physiologicaly is only designed to be activated by DHT it may be feasible that ß-Ionone can bind to other types of receptors that DHT binds to as well, probably through molecular conformation. Since ß-Ionone is a terpene which is highly volatile (due to low molecular mass) and fat-soluble, it is easily absorbed through various tissues and will certainly also reach the brain via inhalation alone.
I'm interested if inhalation of the substance will result in some positive mental effects that some ascribe to DHT in the CNS.
It's a very cheap and unrestricted substance which can be obtained here for example:
Beta Ionone
2ml cost 2USD - it should be diluted with alcohol to 10% or even 1% for anyody interested in testing it as an inhalation agent or sublingualy, so 2ml are plenty.
In the above mentioned study, the authors also indictae that the only other ligand to the prostrate specific OR/DHT receptor they identified is
1,4,6-Androstatriene-3,17-dione - Wikipedia
a potent aromatase inhibitor.
And this study found an OR-receptor activated by ß-Ionone in melatocytes in the skin:
Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes
Does anybody konow about DHT effects on melanocytes or melanin expression?
So it is certainly an interesting compound, ß-Ionone and used in it's natural and synthetic forms since centuries/decades respectively, meaning it is probably a safe substance, granted for internal use even.
Last edited: