Spermidine, Found In Cheese And Semen, Extends Lifespan Of Mice And May Work For Humans

paymanz

Member
Joined
Jan 6, 2015
Messages
2,707
http://www.medicaldaily.com/key-lon...se-and-semen-extends-lifespan-mice-and-404464


http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4222.html


Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for protection against cardiovascular disease.
 

Curiousman

Member
Joined
Aug 2, 2017
Messages
92
Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions.
Ramot Y , et al.

BACKGROUND:
Rapidly regenerating tissues need sufficient polyamine synthesis. Since the hair follicle (HF) is a highly proliferative mini-organ, polyamines may also be important for normal hair growth. However, the role of polyamines in human HF biology and their effect on HF epithelial stem cells in situ remains largely unknown.

METHODS AND FINDINGS:
We have studied the effects of the prototypic polyamine, spermidine (0.1-1 µM), on human scalp HFs and human HF epithelial stem cells in serum-free organ culture. Under these conditions, spermidine promoted hair shaft elongation and prolonged hair growth (anagen). Spermidine also upregulated expression of the epithelial stem cell-associated keratins K15 and K19, and dose-dependently modulated K15 promoter activity in situ and the colony forming efficiency, proliferation and K15 expression of isolated human K15-GFP+ cells in vitro. Inhibiting the rate-limiting enzyme of polyamine synthesis, ornithine decarboyxlase (ODC), downregulated intrafollicular K15 expression. In primary human epidermal keratinocytes, spermidine slightly promoted entry into the S/G2-M phases of the cell cycle. By microarray analysis of human HF mRNA extracts, spermidine upregulated several key target genes implicated e.g. in the control of cell adherence and migration (POP3), or endoplasmic reticulum and mitochondrial functions (SYVN1, NACA and SLC25A3). Excess spermidine may restrict further intrafollicular polyamine synthesis by inhibiting ODC gene and protein expression in the HF's companion layer in situ.

CONCLUSIONS:
These physiologically and clinically relevant data provide the first direct evidence that spermidine is a potent stimulator of human hair growth and a previously unknown modulator of human epithelial stem cell biology.
 

X3CyO

Member
Joined
Sep 19, 2016
Messages
512
Location
Hawaii
Great. Ill let my girlfriend know.
 

Yucca

Member
Joined
Jan 26, 2021
Messages
226
Location
France
I use it for about 2 months, powder form (Raab vitalfood, from wheat germ). Taste is quite...disgusting, I mix it with about 8-9g glycine and 4g taurine pre-bed with a big glass of water +lemon juice.
No noticeable effects, but it's for the long term.
I eat also lots of raw cheese each day (french here, my weakness with dark chocolate), so my total daily spermidine income should be quite high...
 

ReSTART

Member
Joined
Nov 27, 2016
Messages
544
Seems promising


The polyamines spermine, spermidine and putrescine share some basic structural features with L-arginine, the substrate of nitric oxide (NO) synthase. The effects of the polyamines on neuronal NO synthase activity were studied in cytosolic preparations of rat cerebellum and cultured cerebellar granule neurons. Spermine, spermidine and putrescine all inhibited the conversion of [3H]L-arginine to [3H]L-citrulline by NO synthase, with the following rank order of potency: spermine > spermidine > putrescine. These inhibitory effects of the polyamines on [3H]L-citrulline formation were also observed in intact cultured cerebellar granule neurons upon stimulation of N-methyl-D-aspartate (NMDA) receptors. Evidence was obtained, however, that endogenous polyamines are not involved in regulation of NMDA-stimulated NO synthase activity. Thus, the observed inhibitory effects of exogenous polyamines might not reflect a physiological role in modulating NO generation in neurons.


Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut microbiota. Spermidine, a polyamine that acts as an autophagy inducer, has important benefits in patients with aging-associated diseases and metabolic dysfunction. However, the mechanism of spermidine on obesity remains unclear. Here, we show that spermidine intake is negatively correlated with obesity in both humans and mice. Spermidine supplementation causes a significant loss of weight and improves insulin resistance in diet-induced obese (DIO) mice. These effects are associated with the alleviation of metabolic endotoxemia and enhancement of intestinal barrier function, which might be mediated through autophagy pathway and TLR4-mediated microbial signaling transduction. Moreover, spermidine causes the significant alteration of microbiota composition and function. Microbiota depletion compromises function, while transplantation of spermidine-altered microbiota confers protection against obesity. These changes might partly be driven by an SCFA-producing bacterium, Lachnospiraceae NK4A136 group, which was decreased in obese subjects and subsequently increased by spermidine. Notably, the change of Lachnospiraceae NK4A136 group is significantly correlated with enhanced gut barrier function induced by spermidine. Our results indicate that spermidine supplementation may serve as a viable therapy for obesity.


Introduction: Nutritional intervention with the natural polyamine spermidine, an autophagy-enhancing agent, can prevent memory loss in aging model organisms. This is the first human study to evaluate the impact of spermidine supplementation on memory performance in older adults at risk for the development of Alzheimer's disease.

Methods: Cognitively intact participants with subjective cognitive decline (n = 30, 60-80 years of age) were included in this three-months, randomized, placebo-controlled, double-blind Phase IIa pilot trial with a spermidine-rich plant extract supplement. Effects of intervention were assessed using the behavioral mnemonic similarity task, measured at baseline and post-intervention visits. Data analysis was focused on reporting and interpreting effectiveness based on effect sizes.

Results: Memory performance was moderately enhanced in the spermidine group compared with placebo at the end of intervention [contrast mean = .17, 95% confidence interval (CI): -.01, .35, Cohen's d = .77, 95% CI: 0, 1.53]. Mnemonic discrimination ability improved in the spermidine-treated group with a medium effect size (mean difference = -.11, 95% CI: -.19, -.03, Cohen's d = .79, 95% CI: .01, 1.55). A similar effect was not found in the placebo-treated group (mean difference = .07, 95% CI: -.13, .27, Cohen's d = -.20, 95% CI: -.94, .54).

Discussion: In this pilot trial, nutritional spermidine was associated with a positive impact on memory performance in older adults with subject cognitive decline. The beneficial effect might be mediated by stimulation of neuromodulatory actions in the memory system. A follow-up Phase IIb randomized controlled trial will help validate the therapeutic potential of spermidine supplementation and delineate possible neurophysiological mechanisms of action.
 

dabdabdab

Member
Joined
May 28, 2020
Messages
250
Seems promising
 
Joined
Jan 29, 2021
Messages
62
Location
USSA
Could this be an explanation for the some of benefits men experience from nofap?

Tagging one of my favorite nofappers, who may be interested:
@AndrogenicJB
 
Back
Top Bottom