Soybean Oil Causes Obesity More Than Fructose & Coconut Oil

jyb

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Soybean oil is used a lot in rat experiments. I think it's because it's a convenient ingredient to form standardised diets so that all studies follow the same norms for comparability. Obviously this is a problem because then researchers conclude high fat or other variables are bad for the rats, when it could have been just the huge pufa calories these poor animals were forced to eat.
 

signalguy

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I can't believe this isn't getting more of a response here. Doesn't this study basically vindicate Ray on everything he has been saying?
 

haidut

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signalguy said:
I can't believe this isn't getting more of a response here. Doesn't this study basically vindicate Ray on everything he has been saying?

Well, yes, it does. Especially his claims on PUFA and cancer connection. See this from the abstract:
"...Other genes involved in obesity (e.g., Cidec, Cd36), diabetes (Igfbp1), inflammation (Cd63), mitochondrial function (Pdk4) and cancer (H19) were also upregulated by the soybean oil diet. Taken together, our results indicate that in mice a diet high in soybean oil is more detrimental to metabolic health than a diet high in fructose or coconut oil."

Perhaps more importantly, the so-called high coconut diet was still laden with PUFA because "PUFA is essential and the animals would die from it".
"...The basic high fat diet (HFD) had 40 kcal% total fat with 36 kcal% from coconut oil and 4 kcal% from soybean oil. A small amount of soybean oil was added to all HFDs to provide the essential fatty acids linoleic acid (LA, C18:2) and α-linolenic acid (C18:3) (Table 2) [39–41]. In the high soybean oil diet (SO-HFD) a portion of the coconut oil was replaced with soybean oil to give a final concentration of 21 kcal% fat calories from coconut oil and 19 kcal% from soybean oil, of which 10 kcal% were from LA. (Soybean oil is ~55% LA [42]). The high fructose diets (F-HFD and F-SO-HFD) had 25.9 kcal% of energy from added fructose and the same fatty acid composition as HFD and SO-HFD, respectively. The total amounts of carbohydrates and protein were constant across all the diets. Regular vivarium (Viv) chow (Purina Test Diet 5001, Newco Distributors, Rancho Cucamonga, CA) was used as a low fat control. Diets were provided in pellet form, twice weekly for up to 16 or 35 weeks; the amount of food consumed was monitored on a per cage basis."

So, the coconut diet may have had a much more beneficial effect without the added "essential" PUFA. The fructose diet was similarly poisoned. The high fructose and high coconut oil diets still had 6.3% PUFA in them, while the soy oil diet had 28.8% PUFA. So, the conclusion of the study should really be - "all diets with PUFA cause widespread damage, and the more PUFA in the diet the more cancerous it is".
 

kineticz

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When I try phosophotadylcholine 1200mg made from soy lecithin and 250mg choline, the first dose I feel excellent, thereafter I feel really distorted.
 

signalguy

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haidut said:
signalguy said:
I can't believe this isn't getting more of a response here. Doesn't this study basically vindicate Ray on everything he has been saying?

Well, yes, it does. Especially his claims on PUFA and cancer connection. See this from the abstract:
"...Other genes involved in obesity (e.g., Cidec, Cd36), diabetes (Igfbp1), inflammation (Cd63), mitochondrial function (Pdk4) and cancer (H19) were also upregulated by the soybean oil diet. Taken together, our results indicate that in mice a diet high in soybean oil is more detrimental to metabolic health than a diet high in fructose or coconut oil."

Perhaps more importantly, the so-called high coconut diet was still laden with PUFA because "PUFA is essential and the animals would die from it".
"...The basic high fat diet (HFD) had 40 kcal% total fat with 36 kcal% from coconut oil and 4 kcal% from soybean oil. A small amount of soybean oil was added to all HFDs to provide the essential fatty acids linoleic acid (LA, C18:2) and α-linolenic acid (C18:3) (Table 2) [39–41]. In the high soybean oil diet (SO-HFD) a portion of the coconut oil was replaced with soybean oil to give a final concentration of 21 kcal% fat calories from coconut oil and 19 kcal% from soybean oil, of which 10 kcal% were from LA. (Soybean oil is ~55% LA [42]). The high fructose diets (F-HFD and F-SO-HFD) had 25.9 kcal% of energy from added fructose and the same fatty acid composition as HFD and SO-HFD, respectively. The total amounts of carbohydrates and protein were constant across all the diets. Regular vivarium (Viv) chow (Purina Test Diet 5001, Newco Distributors, Rancho Cucamonga, CA) was used as a low fat control. Diets were provided in pellet form, twice weekly for up to 16 or 35 weeks; the amount of food consumed was monitored on a per cage basis."

So, the coconut diet may have had a much more beneficial effect without the added "essential" PUFA. The fructose diet was similarly poisoned. The high fructose and high coconut oil diets still had 6.3% PUFA in them, while the soy oil diet had 28.8% PUFA. So, the conclusion of the study should really be - "all diets with PUFA cause widespread damage, and the more PUFA in the diet the more cancerous it is".

It seems the least fattening diet was the chow diet. That was a low fat diet which is again in line with Peat recommendations.
 
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