Solved? - IBS, SIBO, GERD, LPR, Colitis, Constipation, Celiac, Brain Fog

[Tristan Loscha]

Random Quote
Looking at many situations in which increasing the glucose supply increases lactic acid production and suppresses respiration, leading to maladaptive decrease in cellular energy, I have begun thinking of lactic acid as a toxin.
Ray Peat#241)

What he saw was often insufficient B1-status catastrophizing into temporary or local B1 deficiency.
B1 has really low,but rather dependable oral unsaturated,open-ended uptake.the neurology guy compared
daily1400mg oral as B1-HCL to injected 100 to 200mg of B1.As a note, im advocating against injection,not for it.
it has risk via glass-contamination and shock by injection as contra point.

 

[BeBetter]

Due to necessity, I had to figure out what in the world is causing the SIBO, GERD and LPR epidemic happening here on this very forum and around the world. So I started digging and putting pieces of the puzzle together. And what started to become very clear was the gut issues were related to the brain, and I was starting to see that vitamin deficiencies was the likely cause. These deficiencies are B vitamins along with their cofactors, more specifically vitamin B1 and B3. However, as the saying goes, B vitamins run in a constellation so they all need to be in check.

The diseases of Pellagra(B3 deficiency) and Beriberi(B1 deficiency) are said to have been wiped out via fortification of foods. I disagree. Instead, what I think is that we have widespread Beriberi and Pellagra, or simply put, vitamin deficiencies that is causing the gut issues along with all the many other issues that come along with it.

So as I put my hypothesis together, I start finding others who had the same conclusion as I did, we are basically suffering from high calorie malnutrition. One said person who I found is Dr. Derrick Lonsdale who is a pretty smart fella. He is well up on the research behind Thiamine, how it works etc. He has found a lot of the same things that @haidut has found out about Thiamine. In his practice he was finding that many people were indeed deficient of Thiamine and also that Thiamine could be used as a drug per say, to help many things. He himself figured out that disease and illness is from an energy breakdown, all the same things we are saying here on the forum. He is a pretty smart dude, and has a lot of good info. Of course he does not have it all right, as do neither you nor I, but I am pretty impressed with his knowledge nonetheless.

Some key take aways from Dr. Lonsdale I have gotten so far:
-Thiamine blood tests are not reliable, it does not show how much Thiamine in the cell. Bam! Hello!
-For some people the transport mechanism is broken that moves Thiamine into the cell, for these people Thiamine HCL is not gonna work so well. For these people Allithiamine and Lipothiamine will work better due to them not needing the transport mechanism. So it would not matter how much Thiamine you are taking in via diet, if your transport mechanism is broken.
-It is possible to feel worse if you start taking Thiamine and are very deficient of it. This is known as a "refeeding effect".
-He always insists of taking magnesium with Thiamine.
-It can take a while for the systems to come back online, the enzymes and what have nots. It can take time to overcome this deficiency.
-B1 deficiency very easily messes with the nervous system and brain via Dysautonomia. Boom! There is your gut issues starting to come online.

Here is the blog he writes at:
Derrick Lonsdale, MD

So basically this all comes down to an energy issue. And it does not matter how high your thyroid is if you are not meeting the nutrient requirements or how little PUFA you got, if you do not have the basic elements to generate and utilize ATP. Things are not gonna work well, you brain is not gonna fire off right, your gut is not gonna communicate with the brain as it should so things are gonna get #rekt down there, energy for life is gonna start waxing and waning, hair is gonna start falling out and greying, your gonna get old real fast!

Could all the gut issues, constipation, pale poo, ulcerative colitis where you poop blood and your intestines are ripping apart be a simple vitamin deficiency? I think so...

Check out this thread on where I put the pieces together of constipation:
SIBO, Gut Motility, Constipation. What Is Really Going On? I Will Tell You

Look what @Scenes said in the thread about constipation and B1:

ATP brother, ATP. Bam!

Check out this thread where I nailed down vitamin B3 deficiency as the potential cause of many digestive issues:
SIBO, GERD, LPR, IBS, & Colitis Could Be Vitamin B3 Deficiency - "Niacin Treats Digestive Problems"

And this one where B3 aka Niacin wipes out Ulcerative Colitis! On this very forum @Gorrilahead puts his Ulcerative Colitis in "remission" with Niacin.
Niacin Ameliorates Ulcerative Colitis

Or this one where the long forgotten Pellagra is now being called Celiac Disease and due to this reclassification has people chasing unicorns:
The Case Of Mistaken Identity: How Pellagra Now Thought To Be Rare Became Known As Celiac Disease

And what do a lot of the people who have these gut issues complain of, brain fog! Aka, dementia! Well looky what we have here:
Dementia Or Pellagra? Niacin Deficiency In The 21st Century


So, why do a lot of Peaters Peater out on a Peat diet? Try saying that fast while deficient of B3. I am thinking it's due to B deficiencies. Things start off good, start seeing great results. However, the weight starts piling on, its not fat, its mostly water weight aka Edema! Guess what is connected to obesity and edema, boom, you got it, Thiamine. The skin issues(Pellegra B3) start to raise their ugly head when pushing up hard on the metabolism. And what else? Sugar. Empty calories like Dr. Lonsdale likes to say(the Dr. is all about the fruit so don't think he is not understanding about needing carbs, good try though! ). Sugar(emtpy calorie table sugar) is scientifically proven to worsen B1 deficiency. And guess what else possibly interferes with the B vitamins, coffee. Plus, we start eating "clean" and move away from the unfortified foods. So, then we start pushing our metabolism up hard, calling for even more nutrients, on top of modern day stressors which burn up even more of the B's and what do you got? The perfect storm for Beriberi and Pellagra hell. Or as I would rather say, a simple vitamin deficiency.

Thank you, this is a very valuable post.

I have bookmarked Lonsdale's blog and am looking forward to reading it.

 

[mrdannyg3]

Guys, thought I should post something interesting as I've been following this thread. I am notorious for having low temps/pulse in the morning so I decided to experiment with the B's to see if they would bring them up. I had a late morning snack that included a potato with butter/salt, milk, and some honey. I took 20 mg of B1/200 mg of B3 (niacinamide) afterwards. Prior to the snack I was cold with upper 70's pulse, a 98 flat temp and peeing frequently. Within 30 minutes of the meal I was at 98.7 temp and a 90 pulse which is a significant improvement for me to say the least. I've had this type of meal before and it has never produced this effect; the only difference was the B's this time around. And for the last two hours my temps have been stable in the middle 98's....

 

[Eric88]

Anyone has experience with Candida/yeast gut overgrowth?

I used to think feling dizzy after eating (especially sugars or starches) was due to blood sugar issues but all my lab results are normal.

I only get elevated insulin after eating yet my blood sugar is always fine. I also have elevated amylase.

Turns out Candida and other yeasts in your gut can produce amylase and apparently I get dizzy because the yeast ferments starch in my gut! I think yeasts also could spike insulin. I have history of too much antibiotic use before, and antibiotics are said to lead to yeast overgrowth.

When I take nystatin my after-eating dizzyness, abdominal pulsations and mood swings disappear. I guess I have to restart it again as my culture is largely starch-based, it's hard to eat starch-free here so it came back!

I feel better when avoiding wheat and things with starch but some supplement I drink has gluten and I have no reaction, but I react to potatoes and rice so I think yeast and starches might be the real culprits in my case. A croissant sends me to the WC with gases lol sorry for TMI.

 

[Nighteyes]

Anyone has experience with Candida/yeast gut overgrowth?

I used to think feling dizzy after eating (especially sugars or starches) was due to blood sugar issues but all my lab results are normal.

I only get elevated insulin after eating yet my blood sugar is always fine. I also have elevated amylase.

Turns out Candida and other yeasts in your gut can produce amylase and apparently I get dizzy because the yeast ferments starch in my gut! I think yeasts also could spike insulin. I have history of too much antibiotic use before, and antibiotics are said to lead to yeast overgrowth.

When I take nystatin my after-eating dizzyness, abdominal pulsations and mood swings disappear. I guess I have to restart it again as my culture is largely starch-based, it's hard to eat starch-free here so it came back!

I feel better when avoiding wheat and things with starch but some supplement I drink has gluten and I have no reaction, but I react to potatoes and rice so I think yeast and starches might be the real culprits in my case. A croissant sends me to the WC with gases lol sorry for TMI.

Any plans for how you will get enough calories in case you drop the starch altogether? :) I suppose juices are an option but the liquids become tiresome, not very filling and suboptimal in a social setting. I cannot think of a social meal without starch where I live except ice cream for desert. I do Think you are right in looking at starch as a possible culprit though.

 

[Eric88]

I think I will just lower starches but not avoid tjem completely and stay on nystatin longer (21 days as per studies). Now I quit after 1 box and I also used a very low dose (just 1 tablet per day, it says to use 2 or more, up to 4-5 even!). I guess a single dose per day is less effective as yeast like all bacteria regrows later in the day. It needs serious and multiple nuking!

 

[Bart1]

Question if you supplement thiamin in excess of 300mg’s a day, are there any risks like depletion of other vitamins/minerals?

 

[opson123]

Does anyone remember a SIBO post/thread a while back about an old school doctor treating SIBO with stimulating laxatives? Iirc it was @Amazoniac's post/thread, but I can't find it.

 

[Sulcuscentralis]

One thing maybe slightly off topic but starting to wonder if the requirements of vitamin S (sun, not steroid lol-- and not replacable with vitamin D supplements IMO) and vitamin G (aka grounding) simply can not be replaced by supplements or foods or artificial products and this is why so many people remain sick? How many can honestly say they get lots of sunlight and ungrounded connection to the earth? Sadly I know I can't.

I bring these up in this topic I guess because both the sun and grounding should alleviate inflammation and thus alleviate the load on B vitamins.

How about some vitamin V for men and Vitamin "D" for women?

 

[Sulcuscentralis]

It's unlikely that things as wide ranging as IBS, SIBO, GERD etc etc can be pinpointed to one thing. Personally I've had all of these, and taken plenty of B1, B3, Energin etc... B Vits never seem to have made any difference to these.

Eating slower, chewing food, being less stressed, and occasional Cascara, Betaine and Ox Bile have rally helped.

This! People underestimate the power of relaxing, especially while eating. Parasympathetic nervous system is referred as "rest and digest" for a reason.

 

[Sulcuscentralis]

Anyone has experience with Candida/yeast gut overgrowth?

I used to think feling dizzy after eating (especially sugars or starches) was due to blood sugar issues but all my lab results are normal.

I only get elevated insulin after eating yet my blood sugar is always fine. I also have elevated amylase.

Turns out Candida and other yeasts in your gut can produce amylase and apparently I get dizzy because the yeast ferments starch in my gut! I think yeasts also could spike insulin. I have history of too much antibiotic use before, and antibiotics are said to lead to yeast overgrowth.

When I take nystatin my after-eating dizzyness, abdominal pulsations and mood swings disappear. I guess I have to restart it again as my culture is largely starch-based, it's hard to eat starch-free here so it came back!

I feel better when avoiding wheat and things with starch but some supplement I drink has gluten and I have no reaction, but I react to potatoes and rice so I think yeast and starches might be the real culprits in my case. A croissant sends me to the WC with gases lol sorry for TMI.

It's possible for you to react to other constituents oft he plant other than gluten or the starch itself.

 

[Louise]

Sorry if this article has been added here. It is supportive of the OP. https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo Overton, the author ,suggests that some need lipo/allithiamine. Plain thiamine won't work.

editing to add another article by Overton https://www.eonutrition.co.uk/post/got-sibo-here-s-why-you-need-to-get-your-thiamine-status-checked

 

[achillea]

Derrick Lonsdale says:
December 10, 2019 at 12:57 pm
I am sorry. I didn’t see this until today. You need Lipothiamine from Ecological Formulas in California. Start with 50 mg a day together with 125 mg magnesium taurate. Symptoms will become worse (paradox/refeeding syndrome) for an unpredictable time, as long as a month or so.Gradual improvement will follow and you can then titrate the doses to the symptoms. There is no toxicity. Paradox is a switch from catabolic to anabolic metabolism. POTS is dysautonomia and is typical of thiamine deficiency. Discontinue ALL forms of sugar and sweeteners.

 

[Bart1]

Derrick Lonsdale says:
December 10, 2019 at 12:57 pm
I am sorry. I didn’t see this until today. You need Lipothiamine from Ecological Formulas in California. Start with 50 mg a day together with 125 mg magnesium taurate. Symptoms will become worse (paradox/refeeding syndrome) for an unpredictable time, as long as a month or so.Gradual improvement will follow and you can then titrate the doses to the symptoms. There is no toxicity. Paradox is a switch from catabolic to anabolic metabolism. POTS is dysautonomia and is typical of thiamine deficiency. Discontinue ALL forms of sugar and sweeteners.

Interesting. Why avoidance of sugar if thiamin helps with sugar oxidation?

 

[achillea]

In his articles he is talking about high calorie low nutrition, ie the typical American diet. " Oh I guess I'll have a donut " syndrome. He is very insistent on a full nutrient diet and I think he is making sugar the boogie man to put a stop the insanity of the modern diet.
During the last 200 years of the Kali Yuga, the Vedas say that people will even eat while walking around." Craziness

 

[charlie]

Interesting. Why avoidance of sugar if thiamin helps with sugar oxidation?

He is OK with fruit, and also says honey is probably OK. He thinks that table sugar and sweeteners are basically burning through our B1 and other resources causing us major issues. He calls it high calorie malnutrition. So the mantra often repeated on the forum that sugar(table sugar) burns up your minerals/vitamins he is agreeing with.

 

[Bart1]

He is OK with fruit, and also says honey is probably OK. He thinks that table sugar and sweeteners are basically burning through our B1 and other resources causing us major issues. He calls it high calorie malnutrition. So the mantra often repeated on the forum that sugar(table sugar) burns up your minerals/vitamins he is agreeing with.

Thanks that seem to be my experience as well.

 

[johnwester130]

Due to necessity, I had to figure out what in the world is causing the SIBO, GERD and LPR epidemic happening here on this very forum and around the world. So I started digging and putting pieces of the puzzle together. And what started to become very clear was the gut issues were related to the brain, and I was starting to see that vitamin deficiencies was the likely cause. These deficiencies are B vitamins along with their cofactors, more specifically vitamin B1 and B3. However, as the saying goes, B vitamins run in a constellation so they all need to be in check.

The diseases of Pellagra(B3 deficiency) and Beriberi(B1 deficiency) are said to have been wiped out via fortification of foods. I disagree. Instead, what I think is that we have widespread Beriberi and Pellagra, or simply put, vitamin deficiencies that is causing the gut issues along with all the many other issues that come along with it.

So as I put my hypothesis together, I start finding others who had the same conclusion as I did, we are basically suffering from high calorie malnutrition. One said person who I found is Dr. Derrick Lonsdale who is a pretty smart fella. He is well up on the research behind Thiamine, how it works etc. He has found a lot of the same things that @haidut has found out about Thiamine. In his practice he was finding that many people were indeed deficient of Thiamine and also that Thiamine could be used as a drug per say, to help many things. He himself figured out that disease and illness is from an energy breakdown, all the same things we are saying here on the forum. He is a pretty smart dude, and has a lot of good info. Of course he does not have it all right, as do neither you nor I, but I am pretty impressed with his knowledge nonetheless.

Some key take aways from Dr. Lonsdale I have gotten so far:
-Thiamine blood tests are not reliable, it does not show how much Thiamine in the cell. Bam! Hello!
-For some people the transport mechanism is broken that moves Thiamine into the cell, for these people Thiamine HCL is not gonna work so well. For these people Allithiamine and Lipothiamine will work better due to them not needing the transport mechanism. So it would not matter how much Thiamine you are taking in via diet, if your transport mechanism is broken.
-It is possible to feel worse if you start taking Thiamine and are very deficient of it. This is known as a "refeeding effect".
-He always insists of taking magnesium with Thiamine.
-It can take a while for the systems to come back online, the enzymes and what have nots. It can take time to overcome this deficiency.
-B1 deficiency very easily messes with the nervous system and brain via Dysautonomia. Boom! There is your gut issues starting to come online.

Here is the blog he writes at:
Derrick Lonsdale, MD

So basically this all comes down to an energy issue. And it does not matter how high your thyroid is if you are not meeting the nutrient requirements or how little PUFA you got, if you do not have the basic elements to generate and utilize ATP. Things are not gonna work well, you brain is not gonna fire off right, your gut is not gonna communicate with the brain as it should so things are gonna get #rekt down there, energy for life is gonna start waxing and waning, hair is gonna start falling out and greying, your gonna get old real fast!

Could all the gut issues, constipation, pale poo, ulcerative colitis where you poop blood and your intestines are ripping apart be a simple vitamin deficiency? I think so...

Check out this thread on where I put the pieces together of constipation:
SIBO, Gut Motility, Constipation. What Is Really Going On? I Will Tell You

Look what @Scenes said in the thread about constipation and B1:

ATP brother, ATP. Bam!

Check out this thread where I nailed down vitamin B3 deficiency as the potential cause of many digestive issues:
SIBO, GERD, LPR, IBS, & Colitis Could Be Vitamin B3 Deficiency - "Niacin Treats Digestive Problems"

And this one where B3 aka Niacin wipes out Ulcerative Colitis! On this very forum @Gorrilahead puts his Ulcerative Colitis in "remission" with Niacin.
Niacin Ameliorates Ulcerative Colitis

Or this one where the long forgotten Pellagra is now being called Celiac Disease and due to this reclassification has people chasing unicorns:
The Case Of Mistaken Identity: How Pellagra Now Thought To Be Rare Became Known As Celiac Disease

And what do a lot of the people who have these gut issues complain of, brain fog! Aka, dementia! Well looky what we have here:
Dementia Or Pellagra? Niacin Deficiency In The 21st Century


So, why do a lot of Peaters Peater out on a Peat diet? Try saying that fast while deficient of B3. I am thinking it's due to B deficiencies. Things start off good, start seeing great results. However, the weight starts piling on, its not fat, its mostly water weight aka Edema! Guess what is connected to obesity and edema, boom, you got it, Thiamine. The skin issues(Pellegra B3) start to raise their ugly head when pushing up hard on the metabolism. And what else? Sugar. Empty calories like Dr. Lonsdale likes to say(the Dr. is all about the fruit so don't think he is not understanding about needing carbs, good try though! ). Sugar(emtpy calorie table sugar) is scientifically proven to worsen B1 deficiency. And guess what else possibly interferes with the B vitamins, coffee. Plus, we start eating "clean" and move away from the unfortified foods. So, then we start pushing our metabolism up hard, calling for even more nutrients, on top of modern day stressors which burn up even more of the B's and what do you got? The perfect storm for Beriberi and Pellagra hell. Or as I would rather say, a simple vitamin deficiency.

would this medication be helpful for the things you mentioned ?

it has methylene blue and phenyl salicylate

 

[Sulcuscentralis]

Also people with IBS will have their B-s depleted because of chronic gut inflammation and malabsorption. That was my case anyway. I worked half a year in gastroenterology and there were a lot of cases of people having chronic IBS and the docs would all bunch of tests which gonna come back negative and they would tell the patient that they have a "functional disease" which means there's no (according to the available tests) measurable structural or laboratory deviations and the symptoms are a result of the gut being oversensitive and it's due to stress. A bunch of those patients would probably benefited from B vitamin supplementation.

 

[achillea]

Page 93 Mitocondria, thiamin and Autoimmune Dysfunction by Dr Lonsdale
RETHINKING NUTRITION The symptoms and multimorbidity expressed so commonly in modern disease should remind us that this is exactly how beriberi was expressed in rice-consuming cultures. The approach should obviously begin with dietary correction. However, we have learned from hard-won experience and indeed from the history of thiamine megadoses required in the treatment of beriberi that simple dietary correction is not sufficient. High calorie malnutrition, is so widespread and so damaging to the enzymes that preside over energy metabolism that noncaloric nutrient supplementation is a necessity. In fact, water-soluble vitamins given by intravenous infusion are often necessary to begin the resuscitation of the cofactordeprived enzymes.