SolBan - Liquid Aspirin/Caffeine/Niacinamide Mix

[Ignatius]

@haidut,

I have purchased a couple of bottles of SolBan and my first impressions are very positive. If you haven't already done so, could you explain the difference between aspirin and salicylic acid? I see aspirin listed as an ingredient in the first post but salicylic acid listed as the ingredient on the bottle itself. Is it the case that salicylic acid is the active ingredient in aspirin?

 

[haidut]

@haidut,

I have purchased a couple of bottles of SolBan and my first impressions are very positive. If you haven't already done so, could you explain the difference between aspirin and salicylic acid? I see aspirin listed as an ingredient in the first post but salicylic acid listed as the ingredient on the bottle itself. Is it the case that salicylic acid is the active ingredient in aspirin?

I will change the main thread, thanks for pointing it out. Aspirin is just acetyl-salicylic acid and when applied to skin or ingested it quickly breaks down into acetic and salicylic acid. It is the salicylic acid that is the active ingredient if aspirin, at least as far as increasing metabolism and hair health goes.

 

[Peatogenic]

Fyi, for the theory of Demodex mites overinfestation playing a role in rosacea, ethanol kills them.

 

[haidut]

Fyi, for the theory of Demodex mites overinfestation playing a role in rosacea, ethanol kills them.

Thanks. Were these mites a discussion somewhere earlier in the thread? Was SolBan suggested as a remedy?

 

[Peatogenic]

Thanks. Were these mites a discussion somewhere earlier in the thread? Was SolBan suggested as a remedy?

No, I came across the mite issue separately. More conventional treatment ideas like tea tree oil seem toxic, and I wondered about ethanol.

 

[Alex Jaramillo]

I have a new supplement (SolBan) for people interested in improving skin health or management of issues like hair loss, wrinkles, aging spots, cellulite, or simply protection from the sun.
It can be ordered from the links below:
www.idealabsdc.com

The supplement is for topical use only and consists of a water/ethanol solution containing niacinamide / nicotinamide, caffeine and aspirin. Each one of these ingredients has been shown in multiple human and animal experiments to be beneficial for skin health using topical administration. In addition, the combination of caffeine and niacinamide has been shown to work literally as a sunscreen so this could be an option for people who do not want to be exposed to the toxic excipients in most commercial products. While I do not claim that the product is effective for any medical condition, for information purposes I have listed a number of references below. These studies have looked at effectiveness and safety of each of the ingredients for specific conditions like UV skin damage, hair loss, photoaging, wrinkles, cellulite, skin cancer, dermatitis, acne, pruritis, eczema, psoriasis, etc.

Perhaps the most remarkable aspect of the product is the succinic acid. In recent human trials, it has been shown that increasing ATP levels in the scalp promotes hair growth in male androgenic alopecia, also known as male pattern baldness (MPB). The trials actually used a saturated fatty acid called pentadecanoic acid topically on the scalp and found that the effectiveness of that fatty acid in restoring hair growth was due to its effects on raising scalp levels of succinic acid, and succinic acid then dramatically increased ATP levels. This is not surprising as succinic acid is a very efficient precursor of ATP. So, we added succinic acid to SolBan to replicate the design of those human clinical trials.

Effect of the glyceride of pentadecanoic acid on energy metabolism in hair follicles
"...The effect of the glyceride of pentadecanoic acid (PDG) in treating male pattern alopecia has already been confirmed in a double blind controlled clinical test. In order to study the mechanism of the hair growing effect of PDG, ATP levels were measured in the hair follicles of rabbits. The ATP levels in telogen hair follicles increased remarkably with the application of PDG. To examine this effect, the metabolic properties of pentadecanoic acid (PDA) were investigated using the mitochondrial fraction prepared from guinea-pig hair follicles. It was shown that PDA could be metabolized in hair follicles, and succinic acid, which was formed in the degradation process of PDA, had a remarkable ATP producing ability. These results suggest that the hair growing effect of PDG depends on the efficient supply of energy to hair follicles, and this mechanism seems to be derived from the metabolic property of the odd numbered carbon fatty acid, PDA."

Based on the above study, pentadecanoic acid (another SFA) is now approved in Japan as topical treatment for hair loss.
Clinical Evaluation of The Product Containing Glyceride of Pentadecanoic Acid on Male Pattern Alopecia in Women

A combination of SolBan + Cardenosine (Cardenosine - Liquid Product For R&D) may be even more beneficial due to the additional antiinflammatory and antifibrotic effects of caffeine, niacinamide, aspirin, inosine, B6, etc.

Here are some comments from Ray on the topic of using aspirin, caffeine and niacinamide topically on the skin.
Cherry Angiomas (red Dots On Skin)
"...The sun-damaged areas in rosacea can be directly provided with some of the protective factors by applying them topically. In the same way that topical lactate can cause vasodilation and disturbed energy metabolism (Rendl, et al., 2001), topical niacinamide, progesterone, vitamin K, and coenzyme Q10 can improve the metabolism and function of the local tissues. Riboflavin can probably be useful when applied topically, but because of its extreme sensitivity to light, it should usually be used only internally, unless the treated skin is covered to prevent exposure to light. Topically applied caffeine, even after sun exposure, can reduce local tissue damage (Koo, et al., 2007). Aspirin and saturated fats can also be protective when applied topically."

Note: This product contains raw material(s) meant for external use only, in cosmetic or other formulations designed for such external use.

_________________________________________________________________

SolBan is a liquid mixture of niacinamide, caffeine, and aspirin. These ingredients have been shown in multiple human clinical trials (as well as animal studies) to have a highly protective effect on the skin against a number of harmful agents and processes. The list of harmful agents and processes includes sunlight (UV), metabolic disturbances, aging (wrinkles, cellulite), hormonal imbalance (acne, eczema, melasma), stress, polyunsaturated fats (PUFA), etc.
SolBan is available as a 20 % alcohol (ethanol) solution in a 2oz glass spray bottle. The product is intended and sanctioned for external use only.

Serving size: 5 sprays (about 1ml)
Servings per container: about 60
Each serving contains:

Niacinamide / Nicotinamide - 40 mg
Caffeine - 10 mg
Salicylic acid - 10 mg
Succinic acid - 10 mg

Other ingredients: water, ethanol

The recommended method of administration is spraying the affected skin area until it has a thin layer of the solution and the letting it dry (without rubbing). The product can be used as sunscreen adjuvant (Caffeine and caffeine sodium benzoate have a sunscreen effect, enhance UVB-induced apoptosis, and inhibit UVB-induced skin carcinogenesis in SKH-1 ... - PubMed - NCBI) due to the UV-blocking properties of caffeine and niacinamide / nicotinamide.


1. NIACINAMIDE
Nicotinic acid/niacinamide and the skin. - PubMed - NCBI
Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. - PubMed - NCBI
A review of nicotinamide: treatment of skin diseases and potential side effects. - PubMed - NCBI
Nicotinic acid/niacinamide and the skin. - PubMed - NCBI
Nicotinamide and the skin. - PubMed - NCBI
Nicotinamide - biologic actions of an emerging cosmetic ingredient. - PubMed - NCBI

1.1 Hyperpigmentation and Skin Aging (niacinamide)
Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. - PubMed - NCBI
A review of nicotinamide: treatment of skin diseases and potential side effects. - PubMed - NCBI
Niacinamide - mechanisms of action and its topical use in dermatology. - PubMed - NCBI
Niacinamide: A B vitamin that improves aging facial skin appearance. - PubMed - NCBI
The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparativ... - PubMed - NCBI
Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. - PubMed - NCBI
Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamin... - PubMed - NCBI
Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, ve... - PubMed - NCBI
A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. - PubMed - NCBI
The effect of 2% niacinamide on facial sebum production. - PubMed - NCBI
Moisturizing effects of topical nicotinamide on atopic dry skin. - PubMed - NCBI

1.2 UV Damage (niacinamide)
Nicotinamide-containing sunscreens for use in Australasian countries and cancer-provoking conditions. - PubMed - NCBI
Topical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppre... - PubMed - NCBI
Ultraviolet A radiation: its role in immunosuppression and carcinogenesis. - PubMed - NCBI
Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in primary melanocytes. - PubMed - NCBI
Nicotinamide reduces photodynamic therapy-induced immunosuppression in humans. - PubMed - NCBI
Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin. - PubMed - NCBI
Nicotinamide downregulates gene expression of interleukin-6, interleukin-10, monocyte chemoattractant protein-1, and tumour necrosis factor-α gene ... - PubMed - NCBI
Oral and systemic photoprotection. - PubMed - NCBI
Photoprotective effects of nicotinamide. - PubMed - NCBI
Nicotinamide prevents ultraviolet radiation-induced cellular energy loss. - PubMed - NCBI
Oral nicotinamide protects against ultraviolet radiation-induced immunosuppression in humans. - PubMed - NCBI
UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide. - PubMed - NCBI
[The intervention of nicotinamide on skin melanocyte's cell proliferation after UVA (365 nm) exposed.]. - PubMed - NCBI
Prevention of photoimmunosuppression and photocarcinogenesis by topical nicotinamide. - PubMed - NCBI
Effects of nicotinamide on mouse skin tumor development and its mode of action. - PubMed - NCBI
Nicotinamide and nicotinamide analogues as antitumor promoters in mouse skin. - PubMed - NCBI



2. CAFFEINE
Follicular penetration of topically applied caffeine via a shampoo formulation. - PubMed - NCBI
The role of hair follicles in the percutaneous absorption of caffeine. - PubMed - NCBI
Topical delivery of caffeine from some commercial formulations. - PubMed - NCBI

2.1 Sunscreen effects (caffeine)
Caffeine and caffeine sodium benzoate have a sunscreen effect, enhance UVB-induced apoptosis, and inhibit UVB-induced skin carcinogenesis in SKH-1 ... - PubMed - NCBI

2.2 Skin cancer (caffeine)
Topical applications of caffeine or (−)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice
A novel topical targeting system of caffeine microemulsion for inhibiting UVB-induced skin tumor: characterization, optimization, and evaluation. - PubMed - NCBI
Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice. - PubMed - NCBI
Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB treated mice
Effect of caffeine on UVB-induced carcinogenesis, apoptosis, and the elimination of UVB-induced patches of p53 mutant epidermal cells in SKH-1 mice. - PubMed - NCBI
Protection from photodamage by topical application of caffeine after ultraviolet irradiation. - PubMed - NCBI
Inhibitory effects of tea and caffeine on UV-induced carcinogenesis: relationship to enhanced apoptosis and decreased tissue fat. - PubMed - NCBI
Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in mouse skin. - PubMed - NCBI

2.3 Other skin conditions (caffeine)
The effect of topically applied aspirin on localized circumscribed neurodermatitis. - PubMed - NCBI
Topical treatment of cutaneous herpes simplex virus-1 infection in mice with a specially formulated caffeine gel (Cafon). - PubMed - NCBI
Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro. - PubMed - NCBI
Histopathological evaluation of caffeine-loaded solid lipid nanoparticles in efficient treatment of cellulite. - PubMed - NCBI
Role of Caffeine in the Management of Androgenetic Alopecia
Pharmacokinetics for topically applied caffeine in the rat. - PubMed - NCBI
Effectiveness of topical caffeine in cataract prevention: studies with galactose cataract. - PubMed - NCBI
Evaluation of the efficacy of topical caffeine in the treatment of psoriasis vulgaris. - PubMed - NCBI
Caffeine inhibits paresthesia induced by herpes simplex virus through action on primary sensory neurons in rats. - PubMed - NCBI


3. ASPIRIN
Combined patch containing salicylic acid and nicotinamide: role of drug interaction. - PubMed - NCBI
Design of a transdermal delivery system for aspirin as an antithrombotic drug. - PubMed - NCBI
Transdermal modification of platelet function. A dermal aspirin preparation selectively inhibits platelet cyclooxygenase and preserves prostacyclin... - PubMed - NCBI
Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A rand... - PubMed - NCBI
Topically applied aspirin rapidly decreases histamine-induced itch. - PubMed - NCBI

After reading this I popped 500mgs of niacinamide had 2 cups of coffee and took 81 mgs of aspirin and I must say I feel really positive about life at the moment so I might stick with this routine until I run out.

 

[GeoX]

Yes, succinic acid can irritate the airways if inhaled. I experienced this first hand when preparing SolBan batches. So, holding your breath is probably a good idea while spraying even though the irritation does not seem to happen to everyone.
Thanks for bringing this up.

I too would cough with last year's newly added succinic acid. This latest batch with identical ingredients doesn't cause me to cough. I wonder if anything else has changed.

 

[haidut]

I too would cough with last year's newly added succinic acid. This latest batch with identical ingredients doesn't cause me to cough. I wonder if anything else has changed.

Nothing has changed since last year. Maybe you adapted to it and it does not irritate any more? That's what happened to me at least.

 

[NathanK]

Courtesy of Dr Andro Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant

 

[EquilibriumSW]

Can Solban be used alongside Energin and Tocovit?

 

[tallglass13]

@haidut, Would it be better to use actual PDG instead of succinic acid? What if PDG has more hair growing properties besides succinic acid. There is a company called the Anagen Hair Clinic in Tampa, has a topical called BioProtein that has been around more that 20yrears. they us Pentadeconoic acid as well for hair energy. I just was wondering if Solban contained PDG, might make it a better hair growth supplement. thanks in advance.

 

[haidut]

Can Solban be used alongside Energin and Tocovit?

Sure, I don't see a problem with it. It is mostly a skin-level supplement and should not have much systemic effects.

 

[haidut]

@haidut, Would it be better to use actual PDG instead of succinic acid? What if PDG has more hair growing properties besides succinic acid. There is a company called the Anagen Hair Clinic in Tampa, has a topical called BioProtein that has been around more that 20yrears. they us Pentadeconoic acid as well for hair energy. I just was wondering if Solban contained PDG, might make it a better hair growth supplement. thanks in advance.

If you read the study on pentadecanoic acid I posted in the original SolBan post you will see the authors clearly state that the hair-growth promoting effects of that acid are due to quick conversion into succinic acid and hence ATP levels. I even emailed them with the same question and they said what I just did - raising ATP is the mechanism of action and in theory any pathway through which this can happen is good. This is one reason some people mix SolBan and Cardenosine in the spray bottle and spray on their scalp for hair regrowth.

 

[Kevin Meirs]

I very much like Solban but not so much the Ethanol in it. I assume the Ethanol is necessary to dilute Aspirin, Niacinamide and Coffein properly.
I know that I cant just mix the ingredients of Solban easily together but besides that, would it have the same effect on the skin if one were
just mixing Aspirin, Coffein, Succinid Acid and Niacinmaide in a blender and rigth after that applying it to the skin?

 

[Catecholamine]

@haidut

Does this prevent any of the positive effects of the sun, or only the negative effects?

 

[Orius]

Can anyone testify to its uses for male pattern baldness, especially on the vertex?

I just started using it for hair thinning back there.

 

[LUH 3417]

My cat had what I believe to be ear mites, small hard bumps on her ears with no discharge. I sprayed SolBan on her ears 5-6 times over a week and the bumps have completely disappeared.

 

[aguilaroja]

Recent evidence about niacinamide protecting against skin damage by particulates:

Various concentrations of niacinamde dissolved in DMSO were applied to tissue culture of skin cells.
Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter
"PM2.5 [particulate matter 2.5] notably aggravated skin cell damage by inducing ROS generation, disrupting cellular components, and activating apoptotic pathways. However, cells pre-treated with NIA [niacinamide] were protected from the ROS-induced lipid peroxidation, protein carbonylation, and DNA damage (Fig. 7). NIA also inhibited PM2.5-induced apoptosis by maintaining both Ca2+ levels and mitochondrial membrane potential in a steady state. These results suggest that NIA can protect against PM2.5-induced skin damage."

 

[Braveheart]

Vitamin B3 Prevents And Reverses Skin Cancer

Nicotinamide for Skin Cancer Chemoprevention - SkinCancer.org

 

[Orius]

My review...

Been using it for 1 month now and I have noticed no change to the hair miniaturization on my vertex. My hair is still there but it is thinning. What Solban did was make the rest of the hair on my head (and even my face) grow faster, thicker, healthier. I have to get hair cuts more often now. It has had virtually no impact on my vertex shedding, which seems to still be progressing.

I am going to continue for another month, but I am not hopeful.

My dosage is 5 sprays once daily in the morning after showering. I blow dry my hair, part the hair at the vertex and then spray. I let it sit for a half hour so that it dries and absorbs before styling my hair. There is plenty of direct scalp contact.