Small Molecule Cognitive Enhancer Reverses Age-Related Memory Decline In Mice

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Small molecule cognitive enhancer reverses age-related memory decline in mice | eLife

Drug reverses age-related cognitive decline within days, potentially turning the tide on diseases like Alzheimer’s and dementia

A new experimental drug has confounded scientists after it appeared to reverse age-related cognitive decline in mice seemingly overnight. The research has far-reaching implications for a number of degenerative disease treatments.

A new study tested how effective a drug called ISRIB was in reversing age-related declines in memory and mental flexibility in mice. The team of scientists from the University of California, San Francisco (UCSF) found startling results.

Instead, it appears that cognitive capacities are not irrevocably lost but have been blocked and lay dormant as a result of a mechanism known as the integrated stress response (ISR). This blockage is triggered by a “vicious cycle of cellular stress,” according to Peter Walter, a professor in the UCSF Department of Biochemistry and Biophysics.

Previous studies on mice involving ISRIB found that even brief treatment with the drug can restore normal brain function after a traumatic brain injury almost overnight.
 

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