First, you're saying that they were supposed to be there and the enzymes modified stuff?
Second, are we not supposed to take enzymes?
The enzymes don't do anything that the body's enzymes don't do. They just do it more strongly. But doing it more strongly isn't in itself bad. But overdoing with too large doses is akin to drinking say a day supply of water in one sitting. It's like waterboarding.
And then consider how these enzymes vary in effectiveness. Serrapeptase pound for pound is stronger than Wobenzym, but the effectiveness pertains only to its lysing power. It does not mean it does a better job if it does the lysing too much that it causes the release of too much microbes at one given time that it overwhelms the body's ability to respond to it. This is where going slow and for the longer haul is needed. And when you also add some supplements to deal with the release of microbes or toxins or the inflammationnor whatever can help.
Too strong a dose also risks chunks of plaque falling off and blocking flow in downstream arteries and arterioles and capillaries.
This is experience and know how counts a lot. You don't want to get worse off instead of getting better. The enzyme manufacturers don't give any guidance. Worse, they tell us enzymes are safe and there is no overdosing nor is there any side effect.
That is bull. No matter what assurances are made, always proceed with caution.