Serotonin Weakens Smell Perception

Discussion in 'Scientific Studies' started by Such_Saturation, Apr 17, 2015.

  1. Such_Saturation

    Such_Saturation Member

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  2. answersfound

    answersfound Member

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    Stop trying to be Haidut.
     
  3. InterrogaOmnia

    InterrogaOmnia Member

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    Lol
     
  4. OP
    Such_Saturation

    Such_Saturation Member

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    Now that would be impossible :cool:
     
  5. tara

    tara Member

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    I get exagerrated sensitivity to smells in migraine prodrome.
     
  6. OP
    Such_Saturation

    Such_Saturation Member

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    Have you ever tried some glycine when it happens?
     
  7. tara

    tara Member

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    Yes, but not often and maybe not enough. Do you have experience or knowledge of it being effective once the process is underway?
     
  8. OP
    Such_Saturation

    Such_Saturation Member

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    No but I am interested :mrgreen:
     
  9. tara

    tara Member

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    OK, if I get any dramatic improvements associated with lots of glycine I will post. :)
    I do have some gelatin most days, and therefore during most days with prodrome, and that has not been enough to prevent.
     
  10. haidut

    haidut Member

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    Nice find. From the study:
    "...Odor-evoked synaptic input to glomeruli was attenuated by increased serotonin signaling through serotonin 2C (5-HT2C) receptors and amplified by decreased serotonergic activity. Intravital multiphoton calcium imaging revealed that 5-HT2C receptor activation amplified odor-evoked activity in a subset of juxtaglomerular cells and attenuated glutamate release from ORN terminals via GABA(B) receptors."

    Guess what blocks these 5-HT2C "receptors"? Good old cyproheptadine. So, maybe taking some cypro would alleviate loss of smell or restore it if lost??
     
  11. OP
    Such_Saturation

    Such_Saturation Member

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    So I took to snorting caffeine lately since it works so well and quick, but yesterday something went wrong because it burned very very hard for an hour or so. However I had a level of smell that I've never experienced. I went for a walk and smelled grass even though it hasn't been cut, smelled flowers from far away... at no point in a couple hours was I free from smelling anything. Pretty neat :alien:
     
  12. Makaveli

    Makaveli Member

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    I don't know if it's due to decreased serotonin but I notice bad body odor on men much more since peating. Sometimes it's so bad I almost gag but that never used to happen.
     
  13. pimpnamedraypeat

    pimpnamedraypeat Member

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    I notice my sense of smell peaks after taking thyroid.
     
  14. dookie

    dookie Member

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    @Such_Saturation , @haidut

    Let's not forget that estrogen can make one too sensitive to smells. I think it's why pregnant women are extremely sensitive to smells?
     
  15. OP
    Such_Saturation

    Such_Saturation Member

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    Well for sure the nose was over excited, but it also makes you think how much of our senses are screened out on a normal basis.
     
  16. Giraffe

    Giraffe Member

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  17. shepherdgirl

    shepherdgirl Member

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    maybe this explains the popularity of those scented candles that are so strong i can smell them from a block away...
     
  18. lampofred

    lampofred Member

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    Explains why I have such a bad sense of smell, and why amphetamines make me smell things so strongly...
     
  19. haidut

    haidut Member

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    Actually, pregnant women have a much higher progesterone/estrogen ratio than non-pregnant women. Otherwise they would not be able to maintain pregnancy. So, this example supports the study above as progesterone is anti-serotonin.
     
  20. Integra

    Integra Member

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    Just my two cents: during PMS and around ovulation, I can tell what the neighbors are cooking for dinner, I can smell "out" people who are stressed out, and even other women on their cycle... :pompous: I always assumed it has something to do with high estrogen.
     
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