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Serotonin Regulates Prostate Growth Through Androgen Receptor Modulation
- Thread starter Lokzo
- Start date
So serotonin antagonists would be androgenic by upregukaring AR.
bdawg
Member
Do we know if 5-HTP and 5-AR related activity is the same in prostate tissue as it is for other tissues?
I notice that for a lot of chemicals only prostate cells or prostate cancer cells are tested as a litmus test for AR activity
How do we know this reflects AR activity in other tissues?
I notice that for a lot of chemicals only prostate cells or prostate cancer cells are tested as a litmus test for AR activity
How do we know this reflects AR activity in other tissues?
Ulysses
Member
- Joined
- Feb 13, 2018
- Messages
- 340
Varicocele is the root cause of BPH: Destruction of the valves in the spermatic veins produces elevated pressure which diverts undiluted testostero... - PubMed - NCBI
According to this theory, the real cause is refluxed testosterone-rich blood pooling around the prostate (varicoceles are incredibly common in older men). Under these circumstances, down-regulating the AR makes sense. But what if the prostate is getting a normal exposure to testosterone to begin with? Then it might tip the balance too far in the other direction.
According to this theory, the real cause is refluxed testosterone-rich blood pooling around the prostate (varicoceles are incredibly common in older men). Under these circumstances, down-regulating the AR makes sense. But what if the prostate is getting a normal exposure to testosterone to begin with? Then it might tip the balance too far in the other direction.
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