Mauritio
Member
- Joined
- Feb 26, 2018
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This is just just another angle showing how stress hormones and PUFA affect the whole body negatively.
Increased Blood-brain-barrier permeability(leaky brain) is linked to many diseases :
"Blood–brain barrier dysfunction contributes to pathology in a range of neurological conditions including multiple sclerosis, stroke, and epilepsy, and has also been implicated in neurodegenerative diseases such as Alzheimer’s disease."
(The blood–brain barrier in health and disease: Important unanswered questions | Journal of Experimental Medicine | Rockefeller University Press)
This review shows that:
Serotonin increases BBB permeability and that the 5HT-2 receptors are implicated in that.
Histamine seems to cause leaky brain by increasing Calcium ions in the cell.
Arachidonic acid increases free radicals via lipid peroxidation /COX and LOX ,so its safe to say that all PUFA will have the same effect as they're all causing lipid peroxidation .
" Serotonin (5HT) has been reported to increase blood-brain barrier permeability in some but not all studies. Where barrier opening was seen, there was evidence for activation of 5-HT2 receptors and a calcium-dependent permeability increase. 8. Histamine is one of the few central nervous system neurotransmitters found to cause consistent blood-brain barrier opening. The earlier literature was unclear, but studies of pial vessels and cultured endothelium reveal increased permeability mediated by H2 receptors and elevation of [Ca2+]i and an H1 receptor-mediated reduction in permeability coupled to an elevation of cAMP.
Arachidonic acid is elevated in some neural pathologies and causes gross opening of the blood-brain barrier to large molecules including proteins. There is evidence that arachidonic acid acts via generation of free radicals in the course of its metabolism by cyclooxygenase and lipoxygenase pathways."
Increased Blood-brain-barrier permeability(leaky brain) is linked to many diseases :
"Blood–brain barrier dysfunction contributes to pathology in a range of neurological conditions including multiple sclerosis, stroke, and epilepsy, and has also been implicated in neurodegenerative diseases such as Alzheimer’s disease."
(The blood–brain barrier in health and disease: Important unanswered questions | Journal of Experimental Medicine | Rockefeller University Press)
This review shows that:
Serotonin increases BBB permeability and that the 5HT-2 receptors are implicated in that.
Histamine seems to cause leaky brain by increasing Calcium ions in the cell.
Arachidonic acid increases free radicals via lipid peroxidation /COX and LOX ,so its safe to say that all PUFA will have the same effect as they're all causing lipid peroxidation .
" Serotonin (5HT) has been reported to increase blood-brain barrier permeability in some but not all studies. Where barrier opening was seen, there was evidence for activation of 5-HT2 receptors and a calcium-dependent permeability increase. 8. Histamine is one of the few central nervous system neurotransmitters found to cause consistent blood-brain barrier opening. The earlier literature was unclear, but studies of pial vessels and cultured endothelium reveal increased permeability mediated by H2 receptors and elevation of [Ca2+]i and an H1 receptor-mediated reduction in permeability coupled to an elevation of cAMP.
Arachidonic acid is elevated in some neural pathologies and causes gross opening of the blood-brain barrier to large molecules including proteins. There is evidence that arachidonic acid acts via generation of free radicals in the course of its metabolism by cyclooxygenase and lipoxygenase pathways."
Inflammatory mediators and modulation of blood-brain barrier permeability - PubMed
1. Unlike some interfaces between the blood and the nervous system (e.g., nerve perineurium), the brain endothelium forming the blood-brain barrier can be modulated by a range of inflammatory mediators. The mechanisms underlying this modulation are reviewed, and the implications for therapy of...
pubmed.ncbi.nlm.nih.gov