Constatine
Member
- Joined
- Sep 28, 2016
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- 1,781
Neurotransmitters: The critical modulators regulating gut-brain axis
"Recent studies from our laboratory showed that increased levels of serotonin can enhance quorum sensing in Pseudomonas aeruginosa both in vitro and in vivo (Knecht et al., 2016). Quorum sensing is the process by which bacteria in close proximity are able to communicate with one another through chemical signaling (Castillo-Juárez et al., 2015). This bacterial communication is necessary for biofilm formation, swarming motility, induction of gene expression, exopolysaccharide production, and the exchange of virulence factors (Sauer, 2002; Liu et al., 2015; Abraham, 2016). Therefore, high serotonin levels resulted in increased P. aeruginosa pathogenicity by enhancing biofilm formation and elaboration of virulence factors, in vitro(Knecht et al., 2016). In a mouse model, we observed that animals treated with exogenous serotonin and infected with P. aeruginosa exhibited an increase in intestinal bacterial load and mortality compared to untreated animals. The administration of exogenous serotonin enhanced the production of pro-inflammatory cytokines, increased biofilm formation on mouse intestines and worsened intestinal pathological manifestations. Intriguingly, serotonin was able to restore the ability of avirulent quorum-sensing P. aeruginosa mutant to cause intestinal infection in mice."
Cyproheptadine and other similar substances have potent antibacterial properties: https://www.omicsonline.org/open-ac...s-2161-0703-1000225.php?aid=70559&view=mobile
"Recent studies from our laboratory showed that increased levels of serotonin can enhance quorum sensing in Pseudomonas aeruginosa both in vitro and in vivo (Knecht et al., 2016). Quorum sensing is the process by which bacteria in close proximity are able to communicate with one another through chemical signaling (Castillo-Juárez et al., 2015). This bacterial communication is necessary for biofilm formation, swarming motility, induction of gene expression, exopolysaccharide production, and the exchange of virulence factors (Sauer, 2002; Liu et al., 2015; Abraham, 2016). Therefore, high serotonin levels resulted in increased P. aeruginosa pathogenicity by enhancing biofilm formation and elaboration of virulence factors, in vitro(Knecht et al., 2016). In a mouse model, we observed that animals treated with exogenous serotonin and infected with P. aeruginosa exhibited an increase in intestinal bacterial load and mortality compared to untreated animals. The administration of exogenous serotonin enhanced the production of pro-inflammatory cytokines, increased biofilm formation on mouse intestines and worsened intestinal pathological manifestations. Intriguingly, serotonin was able to restore the ability of avirulent quorum-sensing P. aeruginosa mutant to cause intestinal infection in mice."
Cyproheptadine and other similar substances have potent antibacterial properties: https://www.omicsonline.org/open-ac...s-2161-0703-1000225.php?aid=70559&view=mobile
