Mauritio
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- Joined
- Feb 26, 2018
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Actually this is a study about serotonin ,bacteria and how a certain anti-depressant influences the two first mentioned.
What I find interesting is the central role of only two bacteria: Turicibacter sanguinis and Clostridia. This articles mentioned that researchers found out that those two cause the body to make more serotonin. And that getting rid of those two reduces serotonin by at least 50% !
" ...in mice, a specific mixture of bacteria, consisting mainly of Turicibacter sanguinis and Clostridia, produces molecules that signal to gut cells to increase production of serotonin. When Hsiao's team raised mice without the bacteria, more than 50% of their gut serotonin was missing."
Then the article goes on to say that serotonin itself causes an increased occurrence of those to species:
"In this new study, the researchers added serotonin to the drinking water of some mice and raised others with a mutation (created by altering a specific serotonin transporter gene) that increased the levels of serotonin in their guts. After studying the microbiota of the mice, the researchers discovered that the bacteria Turicibacter and Clostridia increased significantly when there was more serotonin in the gut.
So what we see here is a viscious cycle :
Turicibacter sanguinis and Clostridia --> more serotonin--> Turicibacter sanguinis and Clostridia.
It is reminding me of the self-reinforcing stress-cycle that serotonin is part of together with cortisol ,prolactin,estrogen and the other stress hormones.
Also they found that Turicibater actually acts as a Serotonin transporter into the cell!:
"When they grew Turicibacter sanguinis in the lab, they found that the bacterium imports serotonin into the cell."
The article: Study shows how serotonin and a popular anti-depressant affect the gut's microbiota
The actual study: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut
What I find interesting is the central role of only two bacteria: Turicibacter sanguinis and Clostridia. This articles mentioned that researchers found out that those two cause the body to make more serotonin. And that getting rid of those two reduces serotonin by at least 50% !
" ...in mice, a specific mixture of bacteria, consisting mainly of Turicibacter sanguinis and Clostridia, produces molecules that signal to gut cells to increase production of serotonin. When Hsiao's team raised mice without the bacteria, more than 50% of their gut serotonin was missing."
Then the article goes on to say that serotonin itself causes an increased occurrence of those to species:
"In this new study, the researchers added serotonin to the drinking water of some mice and raised others with a mutation (created by altering a specific serotonin transporter gene) that increased the levels of serotonin in their guts. After studying the microbiota of the mice, the researchers discovered that the bacteria Turicibacter and Clostridia increased significantly when there was more serotonin in the gut.
So what we see here is a viscious cycle :
Turicibacter sanguinis and Clostridia --> more serotonin--> Turicibacter sanguinis and Clostridia.
It is reminding me of the self-reinforcing stress-cycle that serotonin is part of together with cortisol ,prolactin,estrogen and the other stress hormones.
Also they found that Turicibater actually acts as a Serotonin transporter into the cell!:
"When they grew Turicibacter sanguinis in the lab, they found that the bacterium imports serotonin into the cell."
The article: Study shows how serotonin and a popular anti-depressant affect the gut's microbiota
The actual study: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut