natedawggh
Member
- Joined
- Aug 24, 2013
- Messages
- 649
I have had some success at manually lowering my serotonin dominance.
First let me explain why I know I have serotonin dominance and maybe you can see if your symptoms are similar to mine: I have had severe depression and anxiety. I have quite a bit of grey hair for my age (34). This is a sign of serotonin dominance as a manifestation of improper tryptophan metabolism (as I understand it). I also have had severe sleep disturbances, easily gain weight (especially water retention). I also have had difficulties keeping my temperature elevated (lowering temperature is a direct function of serotonin). I also have had dull skin with increasing hair loss and eczema, etc. Serotonin seems to reduce blood supply to the skin. There are probably other symptoms I am not considering at the moment (like my varicocelle and some spider veins in my foot).
Improvements seen: I immediately experienced an increase in mood and a complete elimination of my depression (before was constant and every day... now I only have a bad day maybe once every three weeks). My hair began growing back in right away too. My skin has improved and I've lost a little more weight, (though it doesn't seem to help with weight loss, it does seem to prevent weight gain, especially water retention and constipation). I also experienced an improvement in my libido (this being a consistent and sustained ability to be aroused, and not to become exhausted from sexual activity).
LYSINE
I started this protocol by taking lysine after reading this thread:
viewtopic.php?f=3&t=6004&hilit=lysine
FEVERFEW
I took Feverfew a few years ago. At the time I hadn't noticed any effects, until I stopped taking it and developed a 24 hour, horrible migraine similar to a headache that occurs in caffeine withdrawal. I realized that feverfew is truly a potent serotonin lowering herb as it is said to do (it does this by keeping serotonin bound to platelets). And started using that as well.
Those are the two main therapies. I take one Feverfew and one Lysine in the morning, noon, and night. Lysine seems to reduce serotonin for about 4-6 hours and depending on what you eat. Feverfew will last for about 8-12 hours, also depending on what you eat.
HERE IS A WARNING: if you take these and then cease taking them abruptly, or eat sources of protein that are high in tryptophan without these supplements, you will experience a profound and painful migraine from the sudden increase in serotonin. This is VERY uncomfortable, so if you decide to take them be mindful you have an appropriate supply, time and resources to make sure you don't miss doses. My doses last for some time if I don't eat tryptophan. If I eat tryptophan, I must immediately also take the supplements to avoid the conversion to serotonin. If you need to stop taking them, reduce your dose and frequency over a few days and avoid major sources of tryptophan.
Other unpleasant but beneficial side effects is a reduced stress response and bit of loopiness/balance problems. This is good for long term health, but in the first two weeks if I exerted myself I ran out of energy VERY quickly. Walking uphill, exercising, these were activities that quickly rendered me exhausted. After about two weeks as my metabolism has returned to normal this effect has diminished greatly. I also fell over once in a situation that should have been easy to keep my balance, and sometimes found myself very spacey and checked out, as if I had zoned out as a result of the reduced serotonin in the brain. If this happens to you I wouldn't be alarmed, because long term elevated serotonin in the brain will cause degenerative diseases, and I am happy to be loopy for a little bit to lower that. The elimination of my depression is the best result of this protocol, and I just can't tell you how happy I have been over the last month that I've been doing this (I will also again assert my insistence that alcohol be completely and utterly avoided, otherwise there really is no point in doing any of these as the effect of alcohol is much stronger than any of these supplements). This is also why it is important to support your primary metabolism if you use these, because having adequate carbs, protein, thyroid, etc. will prevent your body from NEEDING the stress response and help keep up your energy levels.
I have noticed that these do not have a permanent effect. If I stop my body still converts tryptophan rapidly into serotonin, which would mean my metabolism is not fully restored at all. So this is merely a stop-gap measure to deal with the awful effects of serotonin dominance. A diet truly low in tryptophan is especially helpful, and I have found the use of casein as my main source of protein to be extremely helpful in getting that ratio while still maintaining a high intake of protein. Dr. Peat has also mentioned how adequate sodium also helps reduce serotonin, so enough sodium should be maintained in the diet.
EDIT: Also, one thing that is pretty obvious for lowering serotonin is high dietary calcium. Not enough calcium raises Parathyroid hormone, which ALWAYS increases serotonin. So to stop that cascade one would need to have high dietary calcium, which I have found be extremely beneficial. This means shooting for 2000mg of calcium. Supplements aren't good, however, because ornate, lactate, and citrate all leach calcium from bones. Milk and Eggshell calcium are the best sources.
First let me explain why I know I have serotonin dominance and maybe you can see if your symptoms are similar to mine: I have had severe depression and anxiety. I have quite a bit of grey hair for my age (34). This is a sign of serotonin dominance as a manifestation of improper tryptophan metabolism (as I understand it). I also have had severe sleep disturbances, easily gain weight (especially water retention). I also have had difficulties keeping my temperature elevated (lowering temperature is a direct function of serotonin). I also have had dull skin with increasing hair loss and eczema, etc. Serotonin seems to reduce blood supply to the skin. There are probably other symptoms I am not considering at the moment (like my varicocelle and some spider veins in my foot).
Improvements seen: I immediately experienced an increase in mood and a complete elimination of my depression (before was constant and every day... now I only have a bad day maybe once every three weeks). My hair began growing back in right away too. My skin has improved and I've lost a little more weight, (though it doesn't seem to help with weight loss, it does seem to prevent weight gain, especially water retention and constipation). I also experienced an improvement in my libido (this being a consistent and sustained ability to be aroused, and not to become exhausted from sexual activity).
LYSINE
I started this protocol by taking lysine after reading this thread:
viewtopic.php?f=3&t=6004&hilit=lysine
FEVERFEW
I took Feverfew a few years ago. At the time I hadn't noticed any effects, until I stopped taking it and developed a 24 hour, horrible migraine similar to a headache that occurs in caffeine withdrawal. I realized that feverfew is truly a potent serotonin lowering herb as it is said to do (it does this by keeping serotonin bound to platelets). And started using that as well.
Those are the two main therapies. I take one Feverfew and one Lysine in the morning, noon, and night. Lysine seems to reduce serotonin for about 4-6 hours and depending on what you eat. Feverfew will last for about 8-12 hours, also depending on what you eat.
HERE IS A WARNING: if you take these and then cease taking them abruptly, or eat sources of protein that are high in tryptophan without these supplements, you will experience a profound and painful migraine from the sudden increase in serotonin. This is VERY uncomfortable, so if you decide to take them be mindful you have an appropriate supply, time and resources to make sure you don't miss doses. My doses last for some time if I don't eat tryptophan. If I eat tryptophan, I must immediately also take the supplements to avoid the conversion to serotonin. If you need to stop taking them, reduce your dose and frequency over a few days and avoid major sources of tryptophan.
Other unpleasant but beneficial side effects is a reduced stress response and bit of loopiness/balance problems. This is good for long term health, but in the first two weeks if I exerted myself I ran out of energy VERY quickly. Walking uphill, exercising, these were activities that quickly rendered me exhausted. After about two weeks as my metabolism has returned to normal this effect has diminished greatly. I also fell over once in a situation that should have been easy to keep my balance, and sometimes found myself very spacey and checked out, as if I had zoned out as a result of the reduced serotonin in the brain. If this happens to you I wouldn't be alarmed, because long term elevated serotonin in the brain will cause degenerative diseases, and I am happy to be loopy for a little bit to lower that. The elimination of my depression is the best result of this protocol, and I just can't tell you how happy I have been over the last month that I've been doing this (I will also again assert my insistence that alcohol be completely and utterly avoided, otherwise there really is no point in doing any of these as the effect of alcohol is much stronger than any of these supplements). This is also why it is important to support your primary metabolism if you use these, because having adequate carbs, protein, thyroid, etc. will prevent your body from NEEDING the stress response and help keep up your energy levels.
I have noticed that these do not have a permanent effect. If I stop my body still converts tryptophan rapidly into serotonin, which would mean my metabolism is not fully restored at all. So this is merely a stop-gap measure to deal with the awful effects of serotonin dominance. A diet truly low in tryptophan is especially helpful, and I have found the use of casein as my main source of protein to be extremely helpful in getting that ratio while still maintaining a high intake of protein. Dr. Peat has also mentioned how adequate sodium also helps reduce serotonin, so enough sodium should be maintained in the diet.
EDIT: Also, one thing that is pretty obvious for lowering serotonin is high dietary calcium. Not enough calcium raises Parathyroid hormone, which ALWAYS increases serotonin. So to stop that cascade one would need to have high dietary calcium, which I have found be extremely beneficial. This means shooting for 2000mg of calcium. Supplements aren't good, however, because ornate, lactate, and citrate all leach calcium from bones. Milk and Eggshell calcium are the best sources.