Serotonin And Nitric Oxide Are The True Causes Of Migraine

Discussion in 'Scientific Studies' started by haidut, Mar 15, 2014.

  1. haidut

    haidut Member

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    Ray has written about the connections between serotonin and migraine, but AFAIK he did not name a direct causative agent. This study claims that serotonin causes release of nitric oxide in the meningeal area of the brain and spinal cord and that is the cause of migraine.

    http://onlinelibrary.wiley.com/doi/10.1 ... ated=false

    The study also implicates a specific serotonin "receptor" where serotonin exerts its action and causes release of NO. The "receptor" is 5-HT2B. A very potent antagonist at that (and others) receptor is cyproheptadine, and not surprisingly there are a number of studies showing that cyproheptadine does indeed reduce migraine symptoms.

    http://www.ncbi.nlm.nih.gov/pubmed/24255866

    Finally, if NO is the direct cause of migraine then agents that reduce NO production should be helpful as well. Two of the better known ones are niacinamide and vitamin B12. I think aspirin has some anti-NO action as well.
     
  2. Wilfrid

    Wilfrid Member

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    Re: Serotonin and nitric oxide are the true causes of migrai

    Good info, haidut.

    For the B12 part, I think that Ray wrote briefly about the hydroxo- form of B12 for reducing NO production in one of his newsletter.

    “One of the most interesting approaches to inhibiting carbon monoxide production is to use vitamin B12, as hydroxocobalamin, as an antidote to nitric oxide, preventing the nitric oxide from stimulating the formation of heme oxygenase. Wherever carbon monoxide mediates a biological malfunction, as in acquired immunodeficiency, Alzheimer’s disease, and cancer, vitamin B12 seems to have a place as a detoxicant.”

    However, this attribution of NO scavenging to solely hydroxocobalamin is because, I think, of the specific research done on it, but the adenosylcobalamin form is probably the real deal here.

    http://www.hy-ls.org/index.php/hyls/art ... load/92/74
     
  3. OP
    haidut

    haidut Member

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    Re: Serotonin and nitric oxide are the true causes of migrai


    Very interesting. What about the more commonly available forms of B12 like cyanocobalamin and methylcobalamin? Do you have any references for those?
     
  4. Wilfrid

    Wilfrid Member

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    Re: Serotonin and nitric oxide are the true causes of migrai

    According to the reference below, the only potent NO scavenger would be the hydroxo- form.
    Cyano-, methyl- and adenosyl- form being, all, far less effective.

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745708/

    Still, I would put my money on the adenosyl.
    What do you think?
     
  5. Logan-

    Logan- Member

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    Hi @haidut, I have been taking 5 grams of pure niacinamide powder to help aborting migraines. I know this is a very big dose, but it helps a little. I have tried lower doses, but found this to be more effective. Can taking this much niacinamide at once be harmful? I drink fruit juice with added sugar after ingesting the niacinamide.

    What are some other things you know that can decrease nitric oxide?
     
  6. OP
    haidut

    haidut Member

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    In doses above 3g it has been known to raise liver enzymes. Peat thinks it should not be used in doses above 1g chronically.
     
  7. Peater

    Peater Member

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    I used to get a severe migraine on average once or twice a year from 2009. Since cutting out nuts and bananas (I was gluten free vegan and Paleo during those times) they have not returned so I agree that serotonin-boosting foods can cause this. I can only assume the 'side-effects' just built up and up until my body couldn't take any more each time.
     
  8. Logan-

    Logan- Member

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