Saturated PS (mitolipin) Dht

[Cameron]

Does saturated PS have an noticable affect on dht I've seen a paper of over 200 percent increase any human studies of this couldnt find any @haidut does ps mechanisms of action make sense in stimulate 5ar androgens

 

[Cameron]

The experiments described in this paper were undertaken to examine the requirements of NADPH-cytochrome c reductase and phosphatidylcholine for hepatic steroid 5 alpha-reduction, previously proposed by Golf and Graef (Golf, S. W. and Graef, V. (1978) J. Steroid Biochem. 9, 369-371). To determine how NADPH-cytochrome c reductase participates in hepatic 5 alpha-reductase activity, antibodies against the purified NADPH-cytochrome c reductase were added to 5 alpha-reductase preparation solubilized from rat liver microsomes. Whereas both NADPH-cytochrome c reductase and progesterone 16 alpha-hydroxylase in the preparation were inhibited by the antiserum, the inhibitory effect on 5 alpha-reductase activity was not observed. In addition, chromatography of the polyethylene glycol fraction active in 5 alpha-reduction on DEAE-cellulose resulted in the complete separation of 5 alpha-reductase activity from NADPH-cytochrome c reductase activity. Unlike NADPH-cytochrome c reductase, phosphatidylcholine increased the activity of the partially purified 5 alpha-reductase about 2.5 fold. Phosphatidylserine also enhanced the activity to an extent identical for phosphatidylcholine. Phosphatidic acid and lysophosphatidylcholine were stimulatory to lesser extents.

 

[Cameron]

2.5 fold increase

 

[haidut]

Does saturated PS have an noticable affect on dht I've seen a paper of over 200 percent increase any human studies of this couldnt find any @haidut does ps mechanisms of action make sense in stimulate 5ar androgens

It does, since as I posted in other threads, saturated fats increase androgen synthesis while PUFA suppress it. PUFA is also one of the most potent 5-AR suppressors we can obtain externally. They also promote estrogen and cortisol synthesis, which increases their anti-androgenic effect.

 

[Cameron]

It does, since as I posted in other threads, saturated fats increase androgen synthesis while PUFA suppress it. PUFA is also one of the most potent 5-AR suppressors we can obtain externally. They also promote estrogen and cortisol synthesis, which increases their anti-androgenic effect.

Stopping pufa was the best thing I've ever done I was just curious how credible these findings were that's a huge increase from a saturated fat and how it actually applies to humans and at what dose?