SARS-cov-2 spike protein activates endotoxin receptor TLR4

Perry Staltic

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"There is a link between high lipopolysaccharide (LPS) levels in the blood and the metabolic syndrome, and metabolic syndrome predisposes patients to severe COVID-19. Here, we define an interaction between SARS-CoV-2 spike (S) protein and LPS, leading to aggravated inflammation in vitro and in vivo."

It's interesting that certain LPS are identified as TLR4 antagonists in one of the links I provided.
 

Perry Staltic

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Lots of people are getting boosters. And you're never going to know who is who when you go into the grocery store or something you know? Last spring, my husband unfortunately got the J&J vaccine, and two days later I started a super-heavy 10 day period even though I was right in the middle of my cycle. Really scary. Now I know that his body was producing Mass amounts of Spike protein and circulating it around the house. Our teen daughter also had a strange cycle that month.

TLR4 activation by the spikes might explain why. I know that activation of TLR9 is responsible for woman's labor. In other words, that's what triggers labor.
 

Perry Staltic

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TLR4 activation by the spikes might explain why. I know that activation of TLR9 is responsible for woman's labor. In other words, that's what triggers labor.

It works like this: fetal DNA fragments from a baby with about 300 base pairs in length are found in a pregnant mother’s serum. When they reach between 0.46– 5.08 ng/mL, they trigger labor via the TLR9 mechanism
 

Perry Staltic

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Toll-like receptors or Tlrs are involved in the innate immune system, meaning nonspecific defenses such as found in the endometrium. They are also involved in menstruation. Tlrs are very sensitive alarms. According to Dr. Peter Hoetez, a noted expert on vaccines, Tlr-7 is particularly sensitive to single-stranded RNA and COVID-19 is a single stranded RNA virus. The Pfizer and Moderna vaccines are single stranded RNA vaccines and the Johnson & Johnson vaccine is double stranded DNA, so if there were any difference between the RNA and DNA vaccines it might support a Tlr-7 theory. Tlr-4 is also involved in menstruation. The RNA vaccines or the inflammatory response from the vaccines might directly trigger bleeding via activation of toll-like receptor signaling.

 

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TLR signaling induced by either external or endogenous signaling molecules can shift the phenotype of macrophages in uterus from an immunosuppressive phenotype towards an inflammatory phenotype, similar to classical activation.

 
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Mauritio

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Mauritio

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Great information! Thank you! I enjoy all your posts, even if I usually don't comment. I have still SO much to learn ( more than I thought I did LOL) ?
You're welcome! I remember you from the niclosamide thread haha
Well, I have so much to learn ,too ! But as peat said : "It doesnt make any sense, until it makes the right kind of sense"
 

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Another study [206] investigated the effect of a phenolic extract obtained from a commercial Italian olive oil in modulating TLR4 signaling that has been reported to be involved in ALS pathogenic mechanisms [207]. The results proved that olive oil phenolic extract induced a complete inhibition of TLR4 activation, prevented the death of motoneurons induced by LPS and in motoneurons/glia co-cultures was very effective in protecting motoneurons from the toxicity of microglia carrying the SOD1G93A mutation.

 
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lvysaur

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Calcitriol (active vitamin D) helped a lot. Aspirin sort of helped, but the help felt "surface level", and there was an underlying weird feeling to it.

It's very telling how little the word "sepsis" is even used when talking about covid. I was able to deduce this back in March 2020 just from my symptoms alone. The big tell-tale sign was my reduced urine output
 
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Calcitriol (active vitamin D) helped a lot. Aspirin sort of helped, but the help felt "surface level", and there was an underlying weird feeling to it.

It's very telling how little the word "sepsis" is even used when talking about covid. I was able to deduce this back in March 2020 just from my symptoms alone. The big tell-tale sign was my reduced urine output
So you had the Rona? How much vitamin D did you take?
 

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Do you know how much olive oil is needed for a significant effect?

This is what they used in that study (EVOO = extra virgin olive oil)

Phenols extraction from EVOO. The phenolic extract was obtained from a commercial Italian
EVOO (Sagra). The EVOO (10 g) was diluted with n-hexane (10 mL) and the polar phenolic fraction
was extracted with a 8:2 solution of MeOH/H2O (100 mL for 3 times). The polar fractions were
collected and evaporated in vacuo at 25 °C to avoid phenols degradation. Phenolic extract was
then dissolved and stocked in EtOH (10 mL). The total phenol content of this solution was
evaluated using the Folin-Ciocalteu method (24) and resulted to be 2.8 mg/mL.

 

lvysaur

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So you had the Rona? How much vitamin D did you take?
Yes, and I took calcitriol, not cholecalciferol. Cholecalciferol had no effect. The label is really worn out, it looks like it was 0.5 mg per pill (I took the pills sporadically, not daily).

Another point of interest: I remember reading that covid decreases the levels of certain endogenous antibiotics. My worst symptom was lack of appetite, and this was totally fixed when I took doxycyline or amoxicillin. So covid not only activates TLR4 by itself, but it temporarily ups the bacteria in your body, which chronically activate TLR4 even further.
 

Perry Staltic

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It's very telling how little the word "sepsis" is even used when talking about covid. I was able to deduce this back in March 2020 just from my symptoms alone. The big tell-tale sign was my reduced urine output

You could have had a kidney infection. I remembered this from early last year when they were into the fear porn thing

“The findings are suggestive of an ascending urinary tract infection, leading to acute pyelonephritis and subsequent sepsis,” Medical Examiner Wendolyn Sneed wrote in the autopsy report late last month, according to The Palm Beach Post.

 
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Peatness

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TLR4 Antagonist

Mianserin
Ketotifen
Cyproheptadine
Naltrexone
Emodin
Vitamin D
Vitamin A
Niacinamide
Riboflavin B2
Methylene Blue
 
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Mauritio

Mauritio

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TLR4 Antagonist

Mianserin
Ketotifen
Cyproheptadine
Naltrexone
Emodin
Vitamin D
Vitamin A
Niacinamide
Riboflavin B2
Methylene Blue
Pregnenolone
Lidocaine
Glycine
Progesterone
 
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Mauritio

Mauritio

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Yes, and I took calcitriol, not cholecalciferol. Cholecalciferol had no effect. The label is really worn out, it looks like it was 0.5 mg per pill (I took the pills sporadically, not daily).

Another point of interest: I remember reading that covid decreases the levels of certain endogenous antibiotics. My worst symptom was lack of appetite, and this was totally fixed when I took doxycyline or amoxicillin. So covid not only activates TLR4 by itself, but it temporarily ups the bacteria in your body, which chronically activate TLR4 even further.
Ok that's weird.

I think that the benefits were due to the general anti inflammatory effects of the doxycycline.
I made a thread about that too.
Antibiotics seem to help a lot of people with covid/vaccine problems .
 

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