SAM-E & TMG Question

[Mito]

im pretty sure the cbs pathway, like mthfr and bhmt, also converts homocysteine to methionine first.

CBS pathway converts homocysteine into cystathionine.

 

[Mito]

can you link to this thread if possible. ive never heard about this. from a search of the forum the only mention of "polyamine" is from you

“Only before: I would think as soon as the rice gets soft, positive pressure from the hot water would physically force the iron into the grain and infuse it with that element. We need to stay free of age spots—lipofuscin—and other inclusion bodies such Lewy bodies and neurofibrillary tangles. Although aluminum should probably be considered the causative agent for the latter two, it displaces iron which could play a formative role. (Both iron and aluminum are commonly found together in inclusion bodies, together with proteins and reactive aldehydic fatty acid remnants polymerized together). Polyunsaturated fatty acids in the brain—and especially in the brain—cannot be avoided as they seem somewhat necessary, but you would think that dietary restriction would lead to lower levels in that area.

I would assume that dementia, at its worse, can largely be avoided by minimizing those three aforementioned; restricting those would leave homocysteine as the biggest factor, which is derived exclusively from methionine. And of course, restricting methionine also restricts the formation of polyamines—powerful small molecule growth factors, which act to physically stabilize/unravel DNA—absolutely essential for cell division. Polyamines are, by the way, the most likely reason why prostate cancer is the number one cancer in the West: The prostate synthesizes high amounts of polyamines for both sperm and seminal fluid, ostensibly for the intention of unraveling and/or stabilizing DNA in the ova—should it get there. The enzymes which synthesize polyamines are temporally upregulated in a manner which reflects the cell cycle. Androgens stimulate polyamine synthesis in the prostate—probably why they are associated with cancer in that organ; polyamines are the downstream mediator.

Polyamines can also be synthesized by arginine and lysine. Methylglyoxal would then, of course, act to inhibit the production polyamines—concomitant with nitric oxide inhibition—by transforming arginine into imidazalone. The anticancer effect of methylglyoxal could be partially be the result of decreased cell division resulting from its ability to disable arginine, thereby preventing excessive polyamine formation.”

Starch And Fat ?

 

[ShotTrue]

Meanwhile methylation, arginine, and lysine are all really positivie for height growth :/

 

[ddjd]

“Only before: I would think as soon as the rice gets soft, positive pressure from the hot water would physically force the iron into the grain and infuse it with that element. We need to stay free of age spots—lipofuscin—and other inclusion bodies such Lewy bodies and neurofibrillary tangles. Although aluminum should probably be considered the causative agent for the latter two, it displaces iron which could play a formative role. (Both iron and aluminum are commonly found together in inclusion bodies, together with proteins and reactive aldehydic fatty acid remnants polymerized together). Polyunsaturated fatty acids in the brain—and especially in the brain—cannot be avoided as they seem somewhat necessary, but you would think that dietary restriction would lead to lower levels in that area.

I would assume that dementia, at its worse, can largely be avoided by minimizing those three aforementioned; restricting those would leave homocysteine as the biggest factor, which is derived exclusively from methionine. And of course, restricting methionine also restricts the formation of polyamines—powerful small molecule growth factors, which act to physically stabilize/unravel DNA—absolutely essential for cell division. Polyamines are, by the way, the most likely reason why prostate cancer is the number one cancer in the West: The prostate synthesizes high amounts of polyamines for both sperm and seminal fluid, ostensibly for the intention of unraveling and/or stabilizing DNA in the ova—should it get there. The enzymes which synthesize polyamines are temporally upregulated in a manner which reflects the cell cycle. Androgens stimulate polyamine synthesis in the prostate—probably why they are associated with cancer in that organ; polyamines are the downstream mediator.

Polyamines can also be synthesized by arginine and lysine. Methylglyoxal would then, of course, act to inhibit the production polyamines—concomitant with nitric oxide inhibition—by transforming arginine into imidazalone. The anticancer effect of methylglyoxal could be partially be the result of decreased cell division resulting from its ability to disable arginine, thereby preventing excessive polyamine formation.”

Starch And Fat ?

thanks for the link, and yes i stand corrected re CBS pathway!

 

[cs3000]

So how is it SAM-E produces an acute anti-depressant effect in a lot of people? considering the high serotonin response Acute changes in 5-HT metabolism after S-adenosyl-l-methionine administration I guess other mechanisms outweigh it? or just like lack of serotonin being a poor target decreasing serotonin also is a poor target being too simplistic?