Safest Tricyclic Antidepressants?

Discussion in 'Pharmaceutical Drugs' started by indeterminacy, Sep 10, 2019.

  1. indeterminacy

    indeterminacy Member

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    Here is what Ray thinks of amitriptyline:

    Help with depression-amitriptyline

    So how does Imipramine and doxepin compare for example?

    I've got a lot of tianeptine left but I want to save it as a last resort because it is really expensive and I have to order it from overseas. I want to make sure if I can buy some cheap safe tricyclic on a local pharmacy first.
     
  2. thomas00

    thomas00 Member

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    Why not get your metabolism in order and use thyroid and/or preg. like Ray suggests?
     
  3. JudiBlueHen

    JudiBlueHen Member

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    I have experience with both TCAs and SSRIs. I can tell you that the TCAs are more gentle and more easily discontinued, though all require a slow taper to discontinue. Personally I liked nortriptyline and doxepin best, but amitriptyline is OK too. Whereas SSRIs caused me to become angry, irritable, and clench my teeth within a week. So I think if you need the AD, you are safer to use a TCA. Also, there are many more years of experience with them and they are generally inexpensive.
     
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