Russia Compounds That Chelate Iron And Inhibits Potential Mitochlndrial Calcium Overload

S.Seneff

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Did you knew that Russia was a peaty country ?!

https://dx.doi.org/10.1080/14756366.2018.1442831

This work highlights the successful development of a new mitochondriotropic antioxidant based on gallic acid that efficiently transports gallic acid to mitochondria without disturbing mitochondrial function and with distinct iron-chelation and antioxidant properties overcoming gallic acid bioavailability drawbacks. AntiOxBEN3 low cytotoxicity profile allows its use in the prevention of mitochondrial oxidative allows its use in the prevention of mitochondrial oxidative damage and in the regulation of oxidative stress pathways. Additionally, it was shown that this type of mitochondriotropic antioxidants can prevent calcium-dependent mPTP opening. So, AntiOxBEN3 can be considered a promising lead compound for the development of a new class of mPTP inhibitors to be used as mPTP de-sensitiser for basic research or clinical applications or undergo an optimisation programme from which a new drug based on gallic acid can emerge for therapeutic application in mitochondria dysfunction-related disorders.
 
EMF Mitigation - Flush Niacin - Big 5 Minerals

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