Hello good people.
Can I ask you what you would do to support your conversion of T4 to T3 and also, in the context of the report below, would 'starvation' relate to fasting or do they mean a lack of the enzyme?
Deiodinase (or "Monodeiodinase") is a peroxidase enzyme that is involved in the activation or deactivation of thyroid hormones.
'In starvation, deiodinase (specifically Deiodinase I) is inhibited thus lowering basal metabolic rate. However, in the brain, heart, skeletal muscle and thyroid, this is not so, as these organs must maintain homeostasis (skeletal muscle through shivering can increase temperature). This is achieved by the latter organs expressing deiodinase II rather than Deiodinase I as in most peripheral tissues. source'
I can see that the Deiodinase enzyme iodthyronine deiodinase needs selenium . Another thread mentioned the importance of iron in this context but I can not find any more info on that.
Any insights appreciated. Thank you.
I am going through one crappy problem at a time and trying to get a better understanding.
Background. I have a history of unexplained rapid weight gain. I have the gene rs2235544(A;A) = Risk of significantly decreased T4-T3 thyroid conversion. I am anaemic. I have the double MTHFR gene. Prolactin high (lactation in menopausal woman) = possible prolactinoma. Possible cushings (buffalo hump, flushing, rapid weight gain)
Can I ask you what you would do to support your conversion of T4 to T3 and also, in the context of the report below, would 'starvation' relate to fasting or do they mean a lack of the enzyme?
Deiodinase (or "Monodeiodinase") is a peroxidase enzyme that is involved in the activation or deactivation of thyroid hormones.
'In starvation, deiodinase (specifically Deiodinase I) is inhibited thus lowering basal metabolic rate. However, in the brain, heart, skeletal muscle and thyroid, this is not so, as these organs must maintain homeostasis (skeletal muscle through shivering can increase temperature). This is achieved by the latter organs expressing deiodinase II rather than Deiodinase I as in most peripheral tissues. source'
I can see that the Deiodinase enzyme iodthyronine deiodinase needs selenium . Another thread mentioned the importance of iron in this context but I can not find any more info on that.
Any insights appreciated. Thank you.
I am going through one crappy problem at a time and trying to get a better understanding.
Background. I have a history of unexplained rapid weight gain. I have the gene rs2235544(A;A) = Risk of significantly decreased T4-T3 thyroid conversion. I am anaemic. I have the double MTHFR gene. Prolactin high (lactation in menopausal woman) = possible prolactinoma. Possible cushings (buffalo hump, flushing, rapid weight gain)