RoundUp (Glyphosate) Finally Proven Toxic - It Depletes Glycine

[Amazoniac]

Haven't read yet..
- Glyphosate does not substitute for glycine in proteins of actively dividing mammalian cells
- Facts and Fallacies in the Debate on Glyphosate Toxicity

 

[Amazoniac]

- The Herbicide Glyphosate and Its Apparently Controversial Effect on Human Health: An Updated Clinical Perspective

 

[Amazoniac]

Facts and Fallacies in the Debate on Glyphosate Toxicity [same as above]

"Syllogisms ['when two or more propositions are used in order to generate a conclusion'] can help in deductive reasoning, but they can also be used to form incorrect conclusions, which are known as syllogism fallacies. Thus, to ensure that syllogisms are used in a constructive rather than a misleading manner, it is necessary to ensure that the two propositions that lead to the conclusion are firmly evidence-based and make biological sense. Frequently quoted trivial but informative examples used to illustrate these points are “All men are mortal, Socrates is a man, therefore Socrates is mortal,” constitutes a meaningful syllogism whereas “All cats are mortal, Socrates is mortal, therefore Socrates is a cat” is clearly a syllogism fallacy! The syllogisms employed by Samsel and Seneff do not appear to have a solid evidential basis and thus could be considered misleading."

"We found that their conclusions are not supported by the available scientific evidence. Thus, the mechanisms and vast range of conditions proposed to result from glyphosate toxicity presented by Samsel and Seneff in their commentaries are at best unsubstantiated theories, speculations, or simply incorrect. This misrepresentation of glyphosate’s toxicity misleads the public, the scientific community, and regulators. Although evidence exists that glyphosate-based herbicides are toxic below regulatory set safety limits, the arguments of Samsel and Seneff largely serve to distract rather than to give a rational direction to much needed future research investigating the toxicity of these pesticides, especially at levels of ingestion that are typical for human populations."​

@tankasnowgod

 

[Re.Generate]

And another - glyphosate also triggers estrogen receptors

Glyphosate induces human breast cancer cells growth via estrogen receptors

Glyphosate is an active ingredient of the most widely used herbicide and it is believed to be less toxic than other pesticides. However, several recen…

www.sciencedirect.com

 

[cedric]

Glyphosate blocks aromatic aminoacids production on the shikimate pathway so we can have less tryptophane/serotonin/melatonin, phenylalanine/tyrosine/dopamine/noradrenaline/adrenaline/L-DOPA/thyroid hormones.
But chorismate and tyrosine/phenylalanine are also needed for the production of quinones like phylloquinone(vit.K1), menaquinone (vitaminK2) and ubiquinone (CoQ10) , PQQ (too?).
Vit.K1 serves as for coagulation factors production but also has antagonistic properties through protein C, S, Z, and calcium.

Phytomenadione - Wikipedia

en.wikipedia.org

Vitamin K - Wikipedia

en.wikipedia.org

" Conversion of vitamin K1 to vitamin K2
In animals, the MK-4 form of vitamin K2 is produced by conversion of vitamin K1 in the testes, pancreas, and arterial walls.[20] While major questions still surround the biochemical pathway for this transformation, the conversion is not dependent on gut bacteria, as it occurs in germ-free rats[39] and in parenterally administered K1 in rats.[40][41] There is evidence that the conversion proceeds by removal of the phytyl tail of K1 to produce menadione (also referred to as vitamin K3) as an intermediate, which is then prenylated to produce MK-4."

VK1 is low in Alzheimers. VK2 is in the (coronary) blood vessels, but VK1- in the heart muscle.
There is a convertion of VK1 to VK2 in testes .
K1 is important for the pancreas. It would be good to write also a book about vitamin K1 ,glyphosate, infertility, dementia, cancer, diabetes, heart diseases.
Some glyphosate formulations can contain arsenic -which lowers selenium, zinc, vitamin A, thiamine/thiols , choline and betaine.

Vitamin K1 deficiency linked to heart enlargement in adolescents

Low intake of phylloquinone (vitamin K1) may be associated with increased risk of enlargement of the major pumping chamber in the heart, new data finds.

www.nutraingredients.com

Phylloquinone and Menaquinone-4 Tissue Distribution at Different Life Stages in Male and Female Sprague–Dawley Rats Fed Different VK Levels Since Weaning or Subjected to a 40% Calorie Restriction since Adulthood

Whether through the vitamin K-dependent proteins or the individual K vitamers, vitamin K (VK) is associated with a number of age-related conditions (e.g., osteoporosis, atherosclerosis, insulin resistance, cognitive decline). In light of this, we investigated the influence of lifetime dietary VK...

www.mdpi.com

Dietary Phylloquinone and Menaquinones Intakes and Risk of Type 2 Diabetes

OBJECTIVE. To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes.RESEARCH DESIGN AND METHODS. We used dat

care.diabetesjournals.org

https://dc.etsu.edu/cgi/viewcontent.cgi?article=4412&context=etd

Concentrations of Circulating Phylloquinone, but Not Cerebral Menaquinone-4, Are Positively Correlated with a Wide Range of Cognitive Measures: Exploratory Findings in Centenarians - PubMed

Circulating VK concentrations are not related to cerebral MK-4 concentrations in centenarians. Cerebral MK-4 concentrations are tightly regulated over a range of VK intakes and cognitive function. Circulating PK may reflect intake of VK-rich foods containing other dietary components beneficial...

pubmed.ncbi.nlm.nih.gov

Concentrations of Circulating Phylloquinone, but Not Cerebral Menaquinone-4, Are Positively Correlated with a Wide Range of Cognitive Measures: Exploratory Findings in Centenarians

Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer's disease - PubMed

An increasing body of evidence points to a role for vitamin K in brain physiology through its participation in sphingolipid metabolism and biological activation of the vitamin K-dependent protein Gas6. One hypothesis is that vitamin K may also play a role in the pathogenesis of Alzheimer's...

pubmed.ncbi.nlm.nih.gov

Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer's disease
VK cycle requires CO2, thiols , reductive factor.

Vitamin K

www.vivo.colostate.edu

Escherichia coli produces vitamin K1 so taking antibiotics, drugs, supplements, a lot of spices could lower pylloquinone production in the intestines. Low VK1 slows brain function memory.

 

[Sitaruîm]

"...Dr. Stephen Frantz, Pathobiologist Research Scientist led the team. “When a cell is trying to form proteins, it may grab glyphosate instead of glycine to form a damaged, mis-folded protein. After that it’s medical chaos. Where glyphosate replaces glycine, the cell can no longer conduct business as usual causing unpredicted consequences with many diseases and disorders as a result.”

I wonder if a higher glycine intake from the diet can prevent or at least reduce the occurrence of this process taking place in the body

 

[Dr. B]

Thanks for posting this! I wonder if aspirin can "deplete" glyphosate similar to glycine like you posted awhile back: Negative effects of aspirin may be due to glycine depletion
Or maybe it would make the situation worse by decreasing available glycine?

It seems that salicylic acid is a common adjunct to herbacide in agriculture as it protects from some of the negative effects:

"SA enhanced growth of Vigna mungo not only in combination with pendimethalin but also in treatment with SA alone as compared to control. Thus the results reveal, the role of SA in protection of Vigna mungo against herbicidal stress is apparent"
"Protein and sugar
contents decreased gradually with increased concentration of herbicide. It might be due to impaired photosynthetic machinery as result of herbicidal stress. Protein, sugar and pigment contents were enhanced in plants under SA treatment. Our results are in agreement with El-Tayeb et al . (2006) who reported promotary effect of SA on pigment, protein and sugar contents of sunflower"
Mitigating effects of salicylic acid against herbicidal stress

@Vileplume

 

[Vileplume]

@Vileplume

Thanks

 

[ddjd]

For more than 2 decades Monsanto has been denying that RoundUp has a provable adverse effects on living organisms. The official reason cited was that there was no known mechanism through which glyphosate (active ingredient in RoundUp) can exert detrimental effects on the cell. Sounds suspiciously similar to the argument given for EMF radiation, except that a mechanism for EMF was recently found. Now, it looks like a mechanism of action for glyphosate has also been found - i.e. it acts like a fake glycine mimetic and blocks cellular uptake of glycine. The result is intracellular depletion of glycine and as a result all hell breaks looose includin cancer, diabetes, autism, Alzheimer, colitis, etc. For anybody doubting Ray's writing on the importance of glycine for cellular health, this discovery about Monsanto should give them a good pause. It would be a bit premature to state it with certainty, but I will make the conjecture that ingesting extra glycine may protect from some of the bad effects of glyphosate due to glycine displaicing the poisonous chemical by competition for entry into the cell. Whether glycine consuptiom can also reverse the various diseases caused by glyphosate I don't know, but Ray has certainly hinted at that possibility by writing about the protective effects of glycine on all of the conditions listed above. I also posted a study recently showing that 96-year old cells can be restored to youthful metabolism by simply providing them with extra glycine. So, I think I am going to have some oxtail soup now given that even the leading scientist behind the study does not expect FDA to act any time soon or maybe at all.

Scientists Seek Ban On Monsanto's RoundUp

"...On Tuesday, a delegation of independent scientists urged the EPA to ban RoundUp, Monsanto’s flagship herbicide at the O’Neill House Office Building in Washington D.C. Providing testimony that it poses an unreasonable risk to humans, animals, and the environment, scientists spoke at a closed meeting with EPA scientists and host Ted Lieu, (CA-33). The scientists explained the physiological reasons why exposure to glyphosate, the active ingredient in RoundUp, is linked to autism, Alzheimer’s, cancer, birth defects, obesity, gluten intolerance, among other health issues."

"...Dr. Stephen Frantz, Pathobiologist Research Scientist led the team. “When a cell is trying to form proteins, it may grab glyphosate instead of glycine to form a damaged, mis-folded protein. After that it’s medical chaos. Where glyphosate replaces glycine, the cell can no longer conduct business as usual causing unpredicted consequences with many diseases and disorders as a result.”

"...RoundUp also harms crops’ ability to capture carbon from the air, an important factor in fighting climate change. “Glyphosate negatively affects the soil microbiome,” said Frantz. “It is destroying the ability of soil to be a nutritive medium for producing crops. Organic or biological regenerative agriculture is the solution for the sustainable agricultural sector and will conserve soil, air and water quality, and sequester carbon that helps to mitigate the climate crisis. We call for a ban on glyphosate.”

"...Frantz wants to see immediate action because he sees the use of glyphosate as outright poisoning of our food and soil. “By the end of 2016, the EPA will have something done and then comment periods, and then there’s another step, and there’s more comment periods, and this is like business as usual. The evidence we presented about this chemical being a glycine analog, that really should excite people. And I didn’t see any excitement. It should upset people.”

View: https://twitter.com/DrJohnB2/status/1484978671920324608?t=bhO8NNeWdvIk0gPr0exXdQ&s=19

 

[Perry Staltic]

View: https://twitter.com/DrJohnB2/status/1484978671920324608?t=bhO8NNeWdvIk0gPr0exXdQ&s=19

Is your partner in denial about glyphosate in canola oil?

 

[ddjd]

View: https://twitter.com/DrJohnB2/status/1484819536167723009?t=8ntOJ2GafDJihpgS7O2qDA&s=19

 

[Texon]

@haidut Noticed your comment much earlier in this thread about supplemental glycine. Would something like 4-6 grams of trimethylglycine suffice?

 

[Motorneuron]

I believe that zeolite but also activated carbon can be useful, to be safe I take it before sleeping away from meals.