Peatogenic
Member
- Joined
- Sep 11, 2017
- Messages
- 746
In the apparent autoimmune condition of rosacea, there was a study that showed higher serum vit D in rosaceans than healthy patients, but it still needs "further research", but that vit D supplementation might be harmful for rosaceans. (https://www.tandfonline.com/doi/abs/10.3109/15569527.2013.797907)
Another study showed lower vitamin D levels but higher cathelicidin levels:
A Study on Vitamin D and Cathelicidin Status in Patients with Rosacea: Serum Level and Tissue Expression
"Higher cathelicidin expression in rosacea supports the hypothesis that an abnormal inflammatory response of the innate immune system is important in pathogenesis of rosacea, but the role of high cathelicidin serum levels is complicated. Serum vitamin D was lower in patients with rosacea, although serum cathelicidin was higher than that of the controls. This suggests that the role of vitamin D level in the pathogenesis of rosacea merits further investigation."
Vitamin D boosts innate immune response by induction of the human gene for cathelicidin, CAMP.
Ray Peat says, "things that cause inflammation stimulate the defensive formation of proteases and cathelicidin"...."so it doesn't seem productive to say that "too much" of those defensive proteins is the cause of rosacea. Isn't it a little like saying that pus is the cause of boils?" Peat seems to recommend things to lower endotoxin for rosacea or correcting nutritional deficiencies like riboflavin. Riboflavin is a known endotoxin antagonist, and I also know of a study that shows riboflavin deficient rats have mite dysregulation (there's a theory of rosacea being a demodex mite dysregulation).
So I'm confused....Vitamin D is anti inflammatory.....the cathelicidin response is supposed to be anti inflammatory...yet it's referred to as causing inflammation in rosaceans, the cause of the inflammation...how could something be both inflammatory and anti inflammatory at the same time?
To avoid sunlight or vit D would just create new imbalances. I kind of understand now the rationale of the Coimbra protocol. Forgive me if I'm missing something basic...im not super studied in this subject.
Another study showed lower vitamin D levels but higher cathelicidin levels:
A Study on Vitamin D and Cathelicidin Status in Patients with Rosacea: Serum Level and Tissue Expression
"Higher cathelicidin expression in rosacea supports the hypothesis that an abnormal inflammatory response of the innate immune system is important in pathogenesis of rosacea, but the role of high cathelicidin serum levels is complicated. Serum vitamin D was lower in patients with rosacea, although serum cathelicidin was higher than that of the controls. This suggests that the role of vitamin D level in the pathogenesis of rosacea merits further investigation."
Vitamin D boosts innate immune response by induction of the human gene for cathelicidin, CAMP.
Ray Peat says, "things that cause inflammation stimulate the defensive formation of proteases and cathelicidin"...."so it doesn't seem productive to say that "too much" of those defensive proteins is the cause of rosacea. Isn't it a little like saying that pus is the cause of boils?" Peat seems to recommend things to lower endotoxin for rosacea or correcting nutritional deficiencies like riboflavin. Riboflavin is a known endotoxin antagonist, and I also know of a study that shows riboflavin deficient rats have mite dysregulation (there's a theory of rosacea being a demodex mite dysregulation).
So I'm confused....Vitamin D is anti inflammatory.....the cathelicidin response is supposed to be anti inflammatory...yet it's referred to as causing inflammation in rosaceans, the cause of the inflammation...how could something be both inflammatory and anti inflammatory at the same time?
To avoid sunlight or vit D would just create new imbalances. I kind of understand now the rationale of the Coimbra protocol. Forgive me if I'm missing something basic...im not super studied in this subject.
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