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- Apr 5, 2016
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Is the method of action for help with withdrawal the reduction of serotonin or its affects on dopamine or both?
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This stuff gives me a puffy face for some reason, like very immediately. Otherwise made me more chill and detached (disconnected?)
Would like to comment on my experience with ritanserin.
The first few nights I took this (full dose) I can remember vividly how much better of sleep I received from this. It really was a night and day difference. I will have to say the effect seemed to drop off after some point...maybe I just became use to it?
I also learned that taking it in the morning had a better effect then at night. Haidut had posted something on this forum that there was a 90% effectiveness when taking in the morning vs 70% taken at night.
I can also comment on the fact that 12 drops was a bit too much for me in the area of mood. It really weighed down on my mood and made many things seemed "unfulfilling" almost as if nothing was satisfying.
I have now dropped down to 3 drops in the morning and 1 drop before bed and experience much better days.
Overall I have to say thank you Haidut for the recommendation. Am on the way to creating a thriving atmosphere within my organism :)
If anyone happens to know, is there something as powerful as this in terms of improving SWS?
haidut how is it going the launch roadmap for that promising full 5-HT1A antagonist? I hoped it was Lecozotan, but you said it isnt... Im very hyped about that after the libido crashing effect that ritanserin had on me..
Did it cause a noticeably increased appetite like Cypro can do?@haidut I really liked Ritanserin's effects, except that it made me gain 12 pounds in one week after finally having gotten down to a weight I was happy about. It's been a struggle to get rid of, though I haven't done any specific dieting techniques yet, being tired of having done them for so long previously. Why would Ritanserin have caused weight gain?
YeahDid it cause a noticeably increased appetite like Cypro can do?
@haidut I really liked Ritanserin's effects, except that it made me gain 12 pounds in one week after finally having gotten down to a weight I was happy about. It's been a struggle to get rid of, though I haven't done any specific dieting techniques yet, being tired of having done them for so long previously. Why would Ritanserin have caused weight gain?
WAY 100 635 is also a good 5-HT1A antagonist. But it costs $450 for 1gm !
No idea, I looked at some older studied on ritanserin and it seems that it had that effects on rats but in high doses only. How much were you experimenting with?
Since it's like cypro, is it understood why cypro will cause weight gain? Shouldn't a reduction in serotonin theoretically cause a reduction in adipose tissue?
Serotonin is an appetite suppressant, cypro lowers serotonin so increases appetite so the weight gain is caused by the increased food now being eaten, I believe is a common explanation.
It was the recommended dosage, but a few days I did it twice. Since it's like cypro, is it understood why cypro will cause weight gain? Shouldn't a reduction in serotonin theoretically cause a reduction in adipose tissue?
Same here. At least I'm pretty sure that's what caused the increased appetite.Yeah
Cyproheptadine is apparently sometimes prescribed to help restore appetite in dangerous anorexia.Since it's like cypro, is it understood why cypro will cause weight gain?
Cyproheptadine is apparently sometimes prescribed to help restore appetite in dangerous anorexia.
Peripheral blockade of serotonin receptors does cause loss in adipose tissues. However, apparently ritanserin and other chemicals like it preferentially target the serotonin receptors in the CNS. Similar to minocycline, which is most active in the CNS even though it has systemic effects as well.
My guess would be like the other comment above - blocking serotonin receptors lowers cortisol and blood sugar thus triggering hunger. I always get hungry if I take ritanserin, lisuride, bromocriptine, cypro, ondansteron, etc and they are all quite consistent in that effect for me.