Riboflavin Metabolism In The Hypothyroid Human Adult

[Coderr]

It had been shown that thyroxine regulates the conversion of riboflavin to riboflavin mononucleotide and flavin adenine dinucleotide (FAD) in laboratory animals. In the hypothyroid rat, the flavin adenine dinucleotide level of the liver decreases to levels observed in riboflavin deficiency. We have shown that in six hypothyroid human adults, the activity of erythrocyte glutathione reductase, an accessible FAD-containing enzyme, is decreased to levels observed during riboflavin deficiency. Thyroxine therapy resulted in normal levels of this enzyme while the subjects were on a controlled dietary regimen. This demonstrates that thyroid hormone regulates the enzymatic conversion of riboflavin to its active coenzyme forms in the human adult.

Riboflavin metabolism in the hypothyroid human adult. - PubMed - NCBI

 

[Elie]

Another piece on issues related to energy metabolism. Thank you.

 

[Sofia]

Good one, o we need coenzymed riboflavin or thyroid then.

 

[milkboi]

So would there be adverse effects of non-activated Riboflavin supplementation with Hypothyroidism?

 

[laleto12]

So would there be adverse effects of non-activated Riboflavin supplementation with Hypothyroidism?

good question as I've just popped a pill

 

[Frankdee20]

Is it a 5 alpha reductase inhibitor ?

 

[GenericName86]

Is it a 5 alpha reductase inhibitor ?

I read that it can be when i was thinking of supplementing it a while ago but i never see that brought up as an effect from people that recommend it so I'm not 100% sure.

 

[Andy316]

Does B2 increase estrogen or decrease it??

 

[Homo Consumericus]

Is it a 5 alpha reductase inhibitor ?

Wiki lists it: List of 5α-reductase inhibitors - Wikipedia.