Riboflavin Metabolism In The Hypothyroid Human Adult

Discussion in 'Thyroid and Hormones' started by Coderr, Feb 24, 2020.

  1. Coderr

    Coderr Member

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    It had been shown that thyroxine regulates the conversion of riboflavin to riboflavin mononucleotide and flavin adenine dinucleotide (FAD) in laboratory animals. In the hypothyroid rat, the flavin adenine dinucleotide level of the liver decreases to levels observed in riboflavin deficiency. We have shown that in six hypothyroid human adults, the activity of erythrocyte glutathione reductase, an accessible FAD-containing enzyme, is decreased to levels observed during riboflavin deficiency. Thyroxine therapy resulted in normal levels of this enzyme while the subjects were on a controlled dietary regimen. This demonstrates that thyroid hormone regulates the enzymatic conversion of riboflavin to its active coenzyme forms in the human adult.

    Riboflavin metabolism in the hypothyroid human adult. - PubMed - NCBI
     
  2. drk

    drk Member

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    Another piece on issues related to energy metabolism. Thank you.
     
  3. Sofia

    Sofia Member

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    Good one, o we need coenzymed riboflavin or thyroid then.
     
  4. milkboi

    milkboi Member

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    So would there be adverse effects of non-activated Riboflavin supplementation with Hypothyroidism?
     
  5. laleto12

    laleto12 Member

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    good question as I've just popped a pill :D
     
  6. Frankdee20

    Frankdee20 Member

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    Is it a 5 alpha reductase inhibitor ?
     
  7. GenericName86

    GenericName86 Member

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    I read that it can be when i was thinking of supplementing it a while ago but i never see that brought up as an effect from people that recommend it so I'm not 100% sure.
     
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