Retinil - Liquid Vitamin A

[haidut]

Is this supplement suppose to be in the form of a white milky like substance? I thought it would be the same sort of colour as other vitamin A liquid supplements?

Yes, this is the expected color as this how retinyl acetate look like when dissolved in water/ethanol.

 

[lollipop]

Is this supplement suppose to be in the form of a white milky like substance? I thought it would be the same sort of colour as other vitamin A liquid supplements?

White milky.

 

[EIRE24]

White milky.

Thanks

 

[EIRE24]

Yes, this is the expected color as this how retinyl acetate look like when dissolved in water/ethanol.

Would this supplement be more potent than nutrisorb A? And the best way to take this is drop on wrist and massage in?

 

[tyler]

Similar question to above.
I've read somewhere, about your MK4 supplement, that to achieve the same blood concentrations, one could use a smaller amount of the vitamin topically in DMSO than they take orally.
Does this carry over to vitamin a as well? Could I use a smaller dose of retinil to achieve the same effects I do from Oral dose of vit a is?

 

[haidut]

Similar question to above.
I've read somewhere, about your MK4 supplement, that to achieve the same blood concentrations, one could use a smaller amount of the vitamin topically in DMSO than they take orally.
Does this carry over to vitamin a as well? Could I use a smaller dose of retinil to achieve the same effects I do from Oral dose of vit a is?

Retinil does not use DMSO, so the absorption is much lower through skin. However, given that vitamin A accumulates in the liver that lower topical absorption may still go a long way since even a high oral dose would deliver most of the vitamin to the liver and peripheral circulation. Don't know the exact ratio of topical-to-oral for vitamin A dissolved in water/ethanol but topical absorption is probably ~25% of the applied amount. And bioavailability from a large oral dose may be as low as 10%. So, an oral dose of 100,000 IU would be about the same as 40,000 IU topically. I am using these numbers just for convenience, not to suggest somebody should be taking that much.

 

[tyler]

Retinil does not use DMSO, so the absorption is much lower through skin. However, given that vitamin A accumulates in the liver that lower topical absorption may still go a long way since even a high oral dose would deliver most of the vitamin to the liver and peripheral circulation. Don't know the exact ratio of topicalral for vitamin A dissolved in water/ethanol but topical absorption is probably ~25% of the applied amount. And bioavailability from a large oral dose may be as low as 10%. So, an oral dose of 100,000 IU would be about the same as 40,000 IU topically. I am using these numbers just for convenience, not to suggest somebody should be taking that much.

Awesome, thanks man.

 

[Braveheart]

How long on skin to get this 80% absorption?

 

[haidut]

How long on skin to get this 80% absorption?

Where do you see references to 80% absorption for Retinil?

 

[DaveFoster]

@haidut

I hate liver, and I want to use Retinil to make up for the retinol I won't be getting from liver. Is there anything I'd be missing from liver apart from the copper, B12, folate, and retinol, and do you think a glandular would be more appropriate?

 

[haidut]

@haidut

I hate liver, and I want to use Retinil to make up for the retinol I won't be getting from liver. Is there anything I'd be missing from liver apart from the copper, B12, folate, and retinol, and do you think a glandular would be more appropriate?

Liver also has vitamins E, K and D, zinc, manganese, as well as some steroids (including thyroid). If you think you are good on these form other sources than I guess you can skip the liver.

 

[DaveFoster]

Liver also has vitamins E, K and D, zinc, manganese, as well as some steroids (including thyroid). If you think you are good on these form other sources than I guess you can skip the liver.

Thanks for the info; I didn't know about the steroids, but I'll give Retinil a shot.

 

[Mufasa]

Try to find fresh liver in a local butcher, much better taste.

Lamb and chicken liver also taste better than cow liver.

 

[Cheesecake]

Hello @haidut I'm using some Retinil for the first time: After not having used any supplemental VitA for a good few months, I tried some orally (2-3 drops) as well as about 8 drops topically over inner wrists and ankles ... the next day I developed tiny pimples all over my face, which have persisted 3 days later.
The only other new thing I can think of that I've tried this week apart from Retinil is 2 drops MB in juice, 2 days in a row. Could it be my liver is being affected by the Retinil or more likely the MB do you think? My skin never normally breaks out like this.

The only other time this has happened was when I tried high(er) dose Niacinamide several years ago. At the time I asked Ray and he said Niacinamide can stress the liver at high doses if it's functioning suboptimally.

I'd love your thoughts!

PS: My temps usually hover between lowish to 36.6+, my pulse in the 80s to 90s, and my blood pressure is on the low side

 

[haidut]

Hello @haidut I'm using some Retinil for the first time: After not having used any supplemental VitA for a good few months, I tried some orally (2-3 drops) as well as about 8 drops topically over inner wrists and ankles ... the next day I developed tiny pimples all over my face, which have persisted 3 days later.
The only other new thing I can think of that I've tried this week apart from Retinil is 2 drops MB in juice, 2 days in a row. Could it be my liver is being affected by the Retinil or more likely the MB do you think? My skin never normally breaks out like this.

The only other time this has happened was when I tried high(er) dose Niacinamide several years ago. At the time I asked Ray and he said Niacinamide can stress the liver at high doses if it's functioning suboptimally.

I'd love your thoughts!

PS: My temps usually hover between lowish to 36.6+, my pulse in the 80s to 90s, and my blood pressure is on the low side

First time we get report like that. Maybe you can stop for a week and see if the pimples disappear? Any other supplements you use that may contains steroids like DHEA? I don't think MB can cause it but I would try a week without Retinil and then a week without MB to see how it affects you.
Just out of curiosity, how much niacinamide were you taking daily and for how long before you saw the pimples develop?

 

[EIRE24]

First time we get report like that. Maybe you can stop for a week and see if the pimples disappear? Any other supplements you use that may contains steroids like DHEA? I don't think MB can cause it but I would try a week without Retinil and then a week without MB to see how it affects you.
Just out of curiosity, how much niacinamide were you taking daily and for how long before you saw the pimples develop?

This same thing happened to me, never figured it out

 

[Cheesecake]

First time we get report like that. Maybe you can stop for a week and see if the pimples disappear? Any other supplements you use that may contains steroids like DHEA? I don't think MB can cause it but I would try a week without Retinil and then a week without MB to see how it affects you.
Just out of curiosity, how much niacinamide were you taking daily and for how long before you saw the pimples develop?

@haidut I'm not taking anything else.
That high dose I tried of niacinamide was 900mg 2 x daily. At the time I emailed Ray and this was his response:
"Such a large amount of niacinamide might affect the way your liver is handling hormones. A large amount of a particular chemical induces specific liver enzymes, causing the liver to specialize in that direction, spending energy that might be better used elsewhere, possibly even lowering its glycogen store."
So I went back to 100mg 2-3 x daily. That was a year ago.

Would you recommend some taurine as a way to support my liver ongoing?

 

[haidut]

@haidut I'm not taking anything else.
That high dose I tried of niacinamide was 900mg 2 x daily. At the time I emailed Ray and this was his response:
"Such a large amount of niacinamide might affect the way your liver is handling hormones. A large amount of a particular chemical induces specific liver enzymes, causing the liver to specialize in that direction, spending energy that might be better used elsewhere, possibly even lowering its glycogen store."
So I went back to 100mg 2-3 x daily. That was a year ago.

Would you recommend some taurine as a way to support my liver ongoing?

Both taurine and glycine should help liver function and glycogen storage.

 

[Cheesecake]

Both taurine and glycine should help liver function and glycogen storage.

Thanks!

 

[haidut]

Just wanted to say that Retinil is now available in palmitate option as well, and the palmitate option is a higher dose per drop - 5,000 IU per drop vs. the 2,400 IU per drop for the acetate version.