Resting Metabolic Rate And Respiratory Quotient In Human Longevity

paymanz

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"Old people are able to metabolize fat at the same rate as younger people, but their overall metabolic rate is lower, because they are unable to oxidize sugar at the same high rate as young people. Fat people have a similar selectively reduced ability to oxidize sugar." -Ray Peat

Resting Metabolic Rate and Respiratory Quotient in Human Longevity | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic

Resting Metabolic Rate and Respiratory Quotient in Human Longevity
M. R. Rizzo D. Mari M. Barbieri E. Ragno R. Grella R. Provenzano I. Villa K. Esposito D. Giugliano G. Paolisso
The Journal of Clinical Endocrinology & Metabolism, Volume 90, Issue 1, 1 January 2005, Pages 409–413, Resting Metabolic Rate and Respiratory Quotient in Human Longevity | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic
Published:
01 January 2005

Abstract
Significant changes in body composition, body fat distribution, and resting metabolic rate (RMR) occur with aging. Interestingly, studies on human longevity pointed out that long-lived subjects are less prone to the anthropometrics and metabolic derangement normally observed in the elderly. Indeed, the relationship between energy expenditure and longevity has been poorly investigated. Thus, energy expenditure parameters of 28 long-lived subjects were assessed and compared with those of 26 adults and 27 younger elderly. All subjects enrolled were female.

In the whole population, RMR was negatively correlated with age (P < 0.05), waist to hip ratio (WHR) (P < 0.001), fat mass (P < 0.001), and percent body fat (P < 0.03); respiratory quotient (Rq) displayed an age-related decrease (P < 0.001) and was negatively correlated with WHR (P < 0.001) and fat-free mass (FFM) (P < 0.006). In multivariate analysis, both RMR and Rq had FFM, WHR, but not body mass index as significant and independent determinants. Splitting the whole study group into subgroups according to age, long-lived subjects had oxygen volume, carbon dioxide volume, and Rq significantly higher than aged subjects but lower than adult subjects. In addition, long-lived subjects had total volume of expired air and RMR greater than aged subjects but not different from ones found in adults. In long-lived subjects, Rq was negatively correlated with percent body fat (P < 0.02), plasma glucose (P < 0.05), free fatty acid (P < 0.05), and WHR (P < 0.05), whereas RMR was negatively correlated with WHR (P < 0.05). No significant associations of RMR and Rq with FFM were found. In conclusion, our data demonstrate that human longevity seems protected toward an age-related decline. It is likely that the lack of the anthropometrics derangement may preserve long-lived subjects from the age-related decrease in energy metabolism.

in long-lived subjects, a preserved Rq may reflect both a predominant use of carbohydrate and a reduced rate of fat oxidation due to the presence of low levels of circulating FFAs
 
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