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Resting Metabolic Rate And Respiratory Quotient In Human Longevity

Giraffe

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"Eighty-one females were divided into three groups: adults (<65 yr old; n = 26), aged subjects (age range 66–94; n = 27), and long-lived subjects (>95 yr old; n = 28) volunteered for the study."

"Indirect calorimetry parameters for each age group are reported in Table 3. Long-lived subjects had VO2, VCO2, and fasting Rq significantly higher than aged subjects but lower than adult subjects. In addition, long-lived subjects had TV and RMR greater than aged subjects but not different from ones found in adults."

"Indeed, the fact that longevity is associated with a greater Rq is in agreement with previous findings on human longevity, showing a preserved glucose metabolism in long-lived subjects (25, 26). The latter relationship is also supported by the evidence that in our study, Rq was found to be negatively associated with fasting plasma glucose levels. Thus, in long-lived subjects, a preserved Rq may reflect both a predominant use of carbohydrate and a reduced rate of fat oxidation due to the presence of low levels of circulating FFAs; in turn, they may associated with the low fat stores and low WHR observed in those individuals."

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