Reports Of Vitamin A Toxicity Are Greatly Exaggerated

Discussion in 'Scientific Studies' started by haidut, Oct 14, 2015.

  1. haidut

    haidut Member

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    This is a human study and as you can see it used up to 500,000 IU vitamin A daily for months for acne treatment without any serious signs of toxicity. Most doctors will warn you that vitamin A will cause liver issues, but as you can see this was not the case here.

    http://www.ncbi.nlm.nih.gov/pubmed/6453848

    "...Oral vitamin A (retinol) is generally not considered useful in the treatment of acne vulgaris. We conducted a study which showed that retinol was indeed ineffective at the usual doses of 50,000 to 100,000 IU daily. Retinol was highly efficacious in doses of 300,000 units for women and 400,000 to 500,000 units for men, toxicity was slight and limited mainly to skin (xerosis) and mucous membranes (cheilitis). The danger of hypervitaminosis A in this dosage range has been exaggerated. Retinol is a valuable drug for treating stubborn, severely inflammatory acne vulgaris. It is administered until the disease is brought under control, usually within three to four months. Then the dosage is progressively reduced relying on conventional drugs to keep the disease in abeyance."
     
  2. lexis

    lexis Member

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    What about anti thyroid effect of Vitamin A?
     
  3. mbarvian

    mbarvian Member

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    Or the fact that liver becomes unpalatable in such doses?
     
  4. OP
    haidut

    haidut Member

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    I thought you may ask about this one. It looks like vitamin A acts just like thyroid.
    viewtopic.php?f=116&t=8131
     
  5. Orion

    Orion Member

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    Would retinol mean the retinyls in this study?

    This study seems to confirm palmitate is OK orally at high doses: [Optimal dosage in peroral therapy of acne with vitamin A palmitate]. - PubMed - NCBI

    Should mention that study does say liver impairment at over 300K for long periods.
     
  6. dfspcc20

    dfspcc20 Member

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    I get a "not found" error.
     
  7. OP
    haidut

    haidut Member

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  8. OP
    haidut

    haidut Member

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  9. Kyle Bigman

    Kyle Bigman Member

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  10. Runenight201

    Runenight201 Member

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    Definitely don't continue to take something that causes pain.

    My train of thought is that in those with compromised liver with saturation of vitamin A stores, more vitamin A can cause issues. Perhaps your body is saturated and the excess A causes problems.

    Liver causes the worst acne in me, but I'm unsure if that's because of my inability to properly digest meats or the vitamin A itself. I also get cysts from consuming ruminant meat. Could be the excess phosphate, methionine, cysteine, and iron that just do my body no good. I get joint pain from eating pasta, and I'm unsure if it's the excess phosphate or gluten. The mental well being I get from eating pasta every now and then far outweighs the temporary joint pain in my opinion.

    I am contemplating with strict Vitamin D supplementation, and continuation of my normal diet, which includes plenty of vitamin A from cheese, OJ, and the occasional leafy greens.

    Looking over the foods eaten in the Vitamin A deficiency diet, I can positively conclude that I would degenerate very quickly eating food like that. Beef, rice, strict restriction of veggies and coconut oil....I don't think I'd make it past day two before feeling very depressed and low energy. I think if one obtains vitamin A from normal food sources (dairy, eggs, fish, veggies) and then supplements with small amounts of D or sunbathes, then all should be good, but I tend to take the minimalist approach towards things.
     
  11. Wahmof10

    Wahmof10 Member

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    Interesting. So is Vitamin A ok or not?
     
  12. Hugh Johnson

    Hugh Johnson Member

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    Yes.
     
  13. bzmazu

    bzmazu Member

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    "I tend to take the minimalist approach towards things."....
    I believe it's the correct/healthy approach....
     
  14. somuch4food

    somuch4food Member

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    It depends on context. I think one must use its own intuition to find what works for himself.

    I am currently monitoring my symptoms in correlation with vitamin A/carotene to see if it fits. I think there might be people that have accumulated too much vitamin A in their body while others are fine with it. I also think the mother provides vitamin A to the child's liver during gestation. So, if your family has an history of high vitamin A intake you might be more prone to vitamin A toxicity. That's my current observation of myself and my toddler. Read about Grant Genereux if you are curious.
     
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