Jun 20, 2015

Repair of Pancreatic β-Cells: A Relevant Phenomenon in EarlyIDDM

Most studies dealing with the pathogenesis of IDDM have emphasized the immune assault against β-cells. In this perspective, we review the data that suggest that the β-cell destruction of IDDM depends on a balance between β-cell damage and repair. The progressive β-cell damage leading to IDDM seems to follow markedly different temporal courses in individual patients. Some individuals at high risk for developing IDDM, and presenting with impaired β-cell function, appear to recover β-cell function when followed prospectively. Moreover, after the clinical onset of IDDM, most patients experience a transitory period of improved insulin secretion. In vitro and in vivo experimental data suggest that β-cells are indeed able to repair themselves after damage. Dispersed β-cells or whole islets can survive and regain their function after a toxic assault. Furthermore, the abnormal insulin release and glucose oxidation of islets isolated from NOD mice during the prediabetic period is completely restored after 1 wk in tissue culture. Finally, treatment of NOD mice with monoclonal antibodies directed against infiltrating T-cells reverses the altered glucose metabolism of β-cells. Note that β-cell repair after exposure to different toxic agents can be enhanced both in vivo and in vitro. Potential enhancers of β-cell repair are nicotinamide, glucose, protein-rich diets, and branched chain amino acids. A basic question that remains to be answered is the nature of the repair mechanisms triggered by β-cells. Some of the β-cell responses to injury include expression of heat shock proteins 32,000, 65,000, 70,000, and 90,000 Mr, activation of the enzyme poly(ADP-ribose) polymerase, induction of the growth arrest and DNA damage inducible genes 45 and 153, and enhanced manganese superoxide dismutase activity. The heat shock protein 70 is of special interest because it has been shown to be both induced by interleukin-1 and protective of β-cells against the deleterious effects of this cytokine. The findings mentioned above suggest that repair mechanisms activated after β-cell injury are an important component of the IDDM disease process. It is conceivable that a detailed characterization of the cellular and molecular mechanisms involved in β-cell repair may contribute to the development of early preventive therapy for IDDM.

Peater Piper

Mar 18, 2016
I've become skeptical of any non-human studies involving beta cells. Rats and mice have been cured of type 1 diabetes as well as type 2 diabetes with some pretty simple interventions, but I'm not aware of any human trials that have successfully cured type 1 diabetes. High dose Niacinamide and vitamin E showed a small amount of promise in prolonging the honeymoon period of LADA patients, but subsequent trials have failed to show benefit. LDN may be of some benefit in LADA before beta cell function is fully lost.
Last edited:
Similar threads
Thread starter Title Forum Replies Date
Sam321 Megasporebiotic vs Florassist to repair gut after Penecillin overuse Ask For Help or Advice 0
Twohandsondeck A gut repair equation - Amino acids > polyphenols > fiber Digestion, Gut Flora 23
T UT Southwestern Surgeons Among World’s First To Repair Aortic Arch Aneurysm With Leading-Edge Techni Articles & Scientific Studies 0
Dan Wich KMUD: 6-15-2018 Positive Thinking, Sleep, And Repair KMUD Radio-The Herb Doctors 12
T What Does One Do To Rebuild Bone Marrow And Repair Other Damage Caused By Methotrexate? Ask For Help or Advice 1
Eric Yim Omega 6 Fatty Acids Good For Muscle Growth, Recovery, And Repair? Polyunsaturated Fats, Seed Oils 0
walker_in_aus Gut Repair After Lots Of Antiobiotics Digestion 82
Seleniodine Environmental Enrichment And Wound Repair In A Colon Tumor Model Scientific Studies 2
S Essential Roles Of Dopamine And Serotonin In Tooth Repair Articles & Scientific Studies 2
P Dopamine D2-like Receptor Agonists Accelerate Barrier Repair And Inhibit The Epidermal Hyperplasia I Articles & Scientific Studies 2
P Molecular Mechanisms Of DNA Repair Inhibition By Caffeine Articles & Scientific Studies 10
burtlancast CELLULAR REPAIR KMUD 2012 Audio Interview Transcripts 4
H Aspirin And Muscle Repair? Aspirin 11
T Is Swelling Necessary For Brain Repair? Health 33
N RP Email Advice Comment: Red Light To Repair Damage From Radiation Genes, Radiation 1
charlie KMUD: Cellular Repair KMUD Radio-The Herb Doctors 0
M How to find out if my digestion is bad because of pancreatic encymes or bile? Digestion, Gut Flora 5
M Causes and cure of pancreatic insufficiency? Ask For Help or Advice 21
haidut Blocking cortisol may treat terminal pancreatic cancer Scientific Studies 6
O Doxycycline Inhibits Cancer Stem Cell-Like Properties via PAR1/FAK/PI3K/AKT Pathway in Pancreatic Cancer Scientific Studies 9
UltraSuperior Is There Anything That Can Be Done For Pancreatic Cancer? Cancer, Degenerative Diseases 26
U Adrenal Fatigue From Pancreatic Insufficiency? Supplements, Pharmaceutical Drugs 13
ddjd Cyproheptadine Induces Loss Of Pancreatic Insulin Ask For Help or Advice 3
D Pancreatic Cancer Questions? Cancer 5
haidut Pancreatic Cancer Driven By Bacteria/endotoxin; Antibiotics Can Prevent/treat Scientific Studies 14
haidut Ketotifen Can Reverse Pancreatic Damage And Improve Digestion Scientific Studies 55
P Diabetogenic Impact Of Long-chain Omega-3 Fatty Acids On Pancreatic Beta-cell Function And The Regul Articles & Scientific Studies 2
haidut Niacinamide Can Cure Liver (and Maybe Pancreatic) Cancer Scientific Studies 28
kiran Aspirin cuts pancreatic cancer risk Scientific Studies 0
Jon2547 Is Potassium Beta-Hydroxybutyrate safe to take? Supplements 2
U Ways to reduce absorption of beta carotene? Vitamins 3
jpgio Consistent Negative reaction to foods high in vitamin A or beta carotene Fat-Soluble Vitamins 5
I Extremely negative reaction to beta carotene? Ask For Help or Advice 26
I How long till excess beta-carotene is removed from the body? Health 5
P What’s the ideal ratio for mixed tocopherols (alpha/gamma/delta/beta) ? Vitamins 5
R Beta-alanine actually works for the burn during exercise (lactic acid) Amino Acids 24
MunenMuso Beta-Sitosterol (Pure Anhydrous) Solubility Ask For Help or Advice 0
J Beta blockers Ask For Help or Advice 3
Hgreen56 Asthma medication (Beta-2 agonists) gives lot of health benefits and perfect for beating corona ? Supplements, Pharmaceutical Drugs 4
S beta carotene Vitamins 4
C Tribulus Terrestris (TT) vs. Beta-Ecdysterone Anabolism Supplements, Pharmaceutical Drugs 11
ddjd Testosterone agonises 11-beta-HSD-1 i.e. raising cortisol!! Ask For Help or Advice 4
Mr.Cacciatore DHEA Agonizes Estrogen Beta Receptor Male Issues 0
Bandooli Beta Blocker - Androgenic Alopecia? Ask For Help or Advice 2
Light "Peaty" Beta-Blockers? Ask For Help or Advice 7
R Lifetime Alcohol Intake Associated With Lower Cerebral Amyloid-beta Deposition Scientific Studies 11
berk Trouble Understanding Vit A And Beta-carotene Recommendations Diet 2
A Any Conjectures On The Connection Between Beta Blockers And Depression? Ask For Help or Advice 0
GorillaHead An Array Of Tocopherols (d-alpha, Beta, Delta, Gamma Tocopherol) Which One? Supplements, Pharmaceutical Drugs 1
R Mushrooms And Beta Glucans Ask For Help or Advice 4

Similar threads